Transient ischemia differentially increases tyrosine phosphorylation of NMDA receptor subunits 2A and 2B

Journal of Neurochemistry

Volumn 69, Issue 3, 1997, Pages 1060-1065

  Takagi, Norio ^a   Shinno, Kiyohito ^a,b   Teves, Lucy ^a   Bissoon, Nankie ^a   Wallace, M Christopher ^a   Gurd, James W ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Brain ischemia; Hippocampus; NMDA receptor; Tyrosine phosphorylation

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT; TYROSINE;

ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CORPUS STRIATUM; ENZYME ACTIVATION; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALIA;

EID: 0030757168     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69031060.x     Document Type: Article

References (34)

1. Anegawa N. J., Lynch D. R., Verdoorn T. A., and Pritchett D. B. (1995) Transfection of N-methyl-D-aspartate receptors in a non-neuronal cell line leads to cell death. J. Neurochem. 64, 2004-2012.
2. Blahos J. II and Wenthold R. J. (1996) Relationship between N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunits. J. Biol. Chem. 271, 15669-15674.
3. Chen S. and Leonard J. P. (1996) Protein tyrosine kinase-mediated potentiation of currents from cloned NMDA receptors. J. Neurochem. 67, 194-200.
4. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
5. Globus M. Y.-T., Busto R., Dietrich W. D., Martinez E., Valdes I., and Ginsberg M. D. (1988) Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and γ-aminobutyric acid studied by intracerebral microdialysis. J. Neurochem. 51, 1455-1464.
6. Gurd J. W. and Bissoon N. (1997) The N-methyl-D-aspartate receptor subunits NR2A and NR2B bind to the SH2 domains of phospholipase C-γ. J. Neurochem. 69, 623-630.
7. Gurd J. W., Bissoon N., and Soulliere J. (1992) Procedures for analysing the tyrosine phosphorylation of synaptic proteins. Neuroprotocols 1, 207-214.
8. Hollman M. and Heinneman S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108.
9. Hu B.-R. and Wieloch T. (1994) Tyrosine phosphorylation and activation of mitogen-activated protein kinases in the rat brain following transient cerebral ischemia. J. Neurochem. 62, 1357-1367.
10. Ishii T., Moriyoshi K., Sugihara H., Sakurada K., Kadotani H., Yokoi M., Akazawa C., Shigemoto R., Mizuno N., Masu M., and Nakanishi S. (1993) Molecular characterization of a family of N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268, 2836-2843.
11. Kindy M. S. (1993) Inhibition of tyrosine phosphorylation prevents delayed neuronal death following cerebral ischemia. J. Cereb. Blood Flow Metab. 13, 372-377.
12. Köhr G. and Seeburg P. H. (1996) Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family. J. Physiol. (Lond.) 492, 445-452.
13. Lau L.-F. and Huganir R. L. (1995) Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 270, 20036-20041.
14. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
15. Luo J., Wang Y., Yasuda R. B., Dunah A. W., and Wolfe B. B. (1997) The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B). Mol. Pharmacol. 51, 79-86.
16. Menegoz M., Lau L.-F., Hervé D., Huganir R. L., and Girault J.-A. (1995) Tyrosine phosphorylation of NMDA receptor in rat striatum: effects of 6-OH-dopamine lesions. Neuroreport 7, 125-128.
17. Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H., Burnashev N., Sakmann B., and Seeburg P. H. (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256, 1217-1221.
18. Moon I. S., Apperson M. L., and Kennedy M. B. (1994) The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B. Proc. Natl. Acad. Sci. USA 91, 3954-3958.
19. Moriyoshi K., Masu M., Ishii T., Shigemoto R., Mizuno N., and Nakanishi S. (1991) Molecular cloning and characterization of the rat NMDA receptor. Nature 354, 31-37.
20. Nakanishi S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258, 597-603.
21. Nellgård B. and Wieloch T. (1992) Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia. J. Cereb. Blood Flow Metab. 12, 2-11.
22. Paschen W. (1996) Glutamate excitotoxicity in transient global cerebral ischemia. Acta Neurobiol. Exp. 56, 313-322.
23. Pulsinelli W. A. and Brierley J. B. (1979) A new model of bilateral hemispheric ischemia in the anaesthetized rat. Stroke 10, 267-272.
24. Pulsinelli W., Sarokin A., and Buchan A. (1993) Antagonism of the NMDA and non-NMDA receptors in global versus focal ischemia. Prog. Brain Res. 96, 125-135.
25. Rosenblum K., Dudai Y., and Richter-Levin G. (1996) Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo. Proc. Natl. Acad. Sci. USA 93, 10457-10460.
26. Rostas J. A. P., Brent V. A., Voss K., Errington M. L., Bliss T. V. P., and Gurd J. W. (1996) Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation. Proc. Natl. Acad. Sci. USA 93, 10452-10456.
27. Sheardown M. J., Nielson E. O., Hansen A. J., Jacobsen P., and Honoré T. (1990) 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo (F)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247, 571-574.
28. Sheng M., Cummings J., Roldan L. A., Jan Y. N., and Jan L. Y. (1994) Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368, 144-147.
29. Slivka A., Brannan T. S., Weinberger J., Knott P. J., and Cohen G. (1988) Increase in extracellular dopamine in the striatum during cerebral ischemia: a study utilizing cerebral microdialysis. J. Neurochem. 50, 1714-1718.
30. Soulliere J., Bissoon N., Khurgel M., and Gurd J. W. (1994) Tyrosine phosphorylation of glycoproteins in the adult and developing rat brain. J. Neurosci. Res. 37, 506-514.
31. Wahlstedt C., Golanov E., Yamamoto S., Yee F., Ericson H., Yoo H., Inturrisi C. E., and Reis D. J. (1993) Antisense oligodeoxy-nucleotides to NMDAR-1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischemic infarctions. Nature 363, 260-263.
32. Wang Y. T. and Salter M. W. (1994) Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369, 233-235.
33. 2+-independent reduction of N-methyl-D-aspartate channel activity by protein tyrosine phosphatase. Proc. Natl. Acad. Sci. USA 93, 1721-1725.
34. Zhang L., Hsu J. C., Takagi N., Gurd J. W., Wallace M. C., and Eubanks J. H. (1997) Transient global ischemia alters NMDA receptor expression in rat hippocampus: correlation with decreased immunoreactive protein levels of the NR2A/2B subunits, and an altered NMDA receptor functionality. J. Neurochem, 69 (in press).