Acidification induces Bax translocation to the mitochondria and promotes ultraviolet light-induced apoptosis

Cellular and Molecular Biology Letters

Volumn 13, Issue 1, 2008, Pages 119-129

  Yang, Lin ^a   Mei, Yongyu ^a   Xie, Qifeng ^a   Han, Xiaoyan ^a   Zhang, Fucheng ^a   Gu, Lin ^a   Zhang, Yufeng ^a   Chen, Youming ^a   Li, Gang ^a   Gao, Zhiliang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Acidification; Apoptosis; Bax; Cancer; Translocation; Ultraviolet light

Indexed keywords

GREEN FLUORESCENT PROTEIN; NIGERICIN; PROTEIN BAX;

ACIDIFICATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER THERAPY; CONTROLLED STUDY; CYTOSOL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IRRADIATION; MITOCHONDRION; MOUSE; NONHUMAN; PH MEASUREMENT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

EID: 43549083908     PISSN: 14258153     EISSN: 16891392     Source Type: Journal    
DOI: 10.2478/s11658-007-0042-x     Document Type: Article

References (30)

1. Adams, J.M. and Cory, S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci.26 (2001) 61–66.
2. Cory, S. and Adams, J.M. The Bcl2 family: Regulators of the cellular life-ordeath switch. Nat. Rev.2 (2002) 647–656.
3. Huang, D. and Strasser, A. BH3-only proteins-essential initiators of apoptotic cell death. Cell103 (2000) 839–842.
4. Wolter, K.G., Hsu, Y.T., Smith, C.L., Nechushtan, A. and Xi, X.G. Movement of bax from the cytosol to mitochondria during apoptosis. J. Cell Biol.139 (1997) 1281–1292.
5. Hsu, Y.T., Wolter, K.G. and Youle, R.J. Cytosol to-membrane redistribution of bax and bcl-xl during apoptosis. Proc. Natl. Acad. Sci. USA94 (1997) 3668–3672.
6. Dejean, L.M., Martinez-Caballero, S., Guo, L., Hughes, C., Teijido, O., Ducret, T., Ichas, F., Korsmeyer, S.J., Antonsson, B., Jonas, E.A. and Kinnally, K.W. Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol. Biol. Cell16 (2005) 2424–2432.
7. Hsu, Y.T. and Youle, R.J. Nonionic detergents induce dimerization among members of the bcl-2 family. J. Biol. Chem.272 (1997) 13829–13834.
8. Smaili, S.S., Hsu, Y.T., Sanders, K.M., Russell, J.T. and Youle, R.J. Bax translication to mitochondria subsequent to rapid loss of mitochondrial membrane potential. Cell Death Differ.8 (2001) 909–920.
9. Antonsson, B., Montessuit, S., Sanchez, B. and Martinou, J.C. Bax is presents as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J. Biol. Chem.276 (2001) 1615–1623.
10. Dubrez, L, Coll, J.L., Hurbin, A., Solary, E. and Favrot M.C. Caffeine sensitizes human H358 cell line to p53-mediated apoptosis by inducing mitochondrial translocation and conformational change of BAX protein. J. Biol. Chem.276 (2001)38980–38987.
11. Gottlieb, R.A., Nordberg, J., Skowronski, E. and Babior, B.M. Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc. Natl. Acad. Sci. USA93 (1996) 654–658.
12. Sala, P.P., Escobar, D.C. and Mollinedo, F. Intracellular alkalinization suppresses lovastation-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J. Biol. Chem.270 (1995) 6235–6242.
13. Barriere, H., Poujeol, C., Tauc, M. and Blasi, J.M. CFTR modulates programmed cell death by decreasing intracellular pH in Chinese hamaster lung fibroblasts. Am. J. Physiol. Cell Physiol.281 (2001)C810–824.
14. Barry, M.A., Reynolds, J.E. and Eastman, A. Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification. Cancer Res.53 (10 Suppl.) (1993) 2349–2357.
15. Goossens, J.F., Henichart, J.P., Dassonneville, L., Facompre, M. and Bailly, C. Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells. Eur. J. Pharm. Sci.10 (2000) 125–131.
16. Angoli, D., Delia, D. and Wanke, E. Early cytoplasmic acidification in retinamide-mediatewd apoptosis of human promyelocytic leukemia cells. Biochem. Biophys. Res. Commun.229 (1996) 681–685.
17. Famulski, K.S., Macdonald, D., Paterson, M.C. and Sikora, E. Activation of a low pH-dependent unclease by apoptotic agents. Cell Death Differ.6 (1999) 281–289.
18. Segal, M.S. and Beem, E. Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity. Am. J. Physiol. Cell Physiol.281 (2001) C1196–1204.
19. Furlong, I.J., Ascaso, R., Rivas, A.L. and Collins, M.K. Intracellular acidification induces apoptosis by stimulating ICE-like protease. J. Cell Sci.110 (1997) 653–661.
20. Williams, A.C., Collard, T.J. and Paraskeva, C. An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene18 (1999) 3199–3204.
21. Collins, M.K., Furlong, I.J., Malde, P., Ascaso, R. and Oliver, J. An apoptotic endonuclease activated either by decreasing pH or by increasing calcium. J. Cell Sci.109 (1996) 2393–2399.
22. Juin, P., Hueber, A.O., Littlewood, T. and Evan, G. c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes Dev.13 (1999) 1367–1381.
23. Jia, L., Macey, M.G., Yin, Y., Newland, A.C. and Kelsev, S.M. Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells and undergoing apoptosis. Blood93 (1999) 2353–2359.
24. Haq, R. and Zanke, B. Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance. Cancer Metastasis Rev.17 (1998) 233–239.
25. Yamagata, M. and Tannock, I.F. The chronic administration of drugs that inhibit the regulation of intracellular pH: invitro and anti-tumour effects. Br. J. Cancer73 (1996) 1328–1334.
26. Newell, K., Wood, P., Stratford, I. and Tannock, I. Effects of agents which inhibit the regulation of intracellular pH on murine solid tumour. Br. J. Cancer66 (1992) 311–317.
27. Suzuki, M., Youle, R.J. and Tjandra, N. Structure of bax: co-regulation of dimmer formation and intracellular localization. Cell103 (2000) 645–654.
28. Cartron, P.F., Moreau, C., Oliver, L., Mayat, E., Meflah, K. and Vallette, F.M. Involvement of the N-terminus of bax in its intracellular l ocalization and function. FEBS Lett.512 (2002) 95–100.
29. Gross, A., Jockel, J., Wei, M.C. and Korsmeyer, S.J. Enforced dimerization of bax results its translocation, mitochondrial dysfunction and apoptosis. EMBO J.17 (1998) 3878–3885.
30. Stubbs, M., McSheehy, P.M., Griffiths, J.R. and Bashford, C.L. Causes and consequences of tumor acidity and implications for treatment. Mol. Med. Today6 (2000) 15–19.