A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitis

Journal of Immunology

Volumn 173, Issue 5, 2004, Pages 3446-3455

  Weigmann, Benno ^a   Nemetz, Andrea ^a   Becker, Christoph ^a   Schmidt, Jan ^c   Strand, Dennis ^a   Lehr, Hans A ^a   Galle, Peter R ^a   Ho, I Cheng ^b   Neurath, Markus F ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; DNA; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; LEUCINE ZIPPER PROTEIN; NEUTRALIZING ANTIBODY; PADGEM PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR C MAF; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LAMINA PROPRIA; MALE; MEMORY CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH1 CELL; TRANSGENIC MOUSE; ULCERATIVE COLITIS;

EID: 4344682018     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.5.3446     Document Type: Article

References (49)

1. Podolsky, D. K. 2002. Inflammatory bowel disease. N. Engl. J. Med. 347:417.
2. Strober, W., and M. F. Neurath. 1995. Immunological diseases of the gastrointestinal tract. In Clinical Immunology, Ch. 94. R. R. Rich, ed. Mosby, St. Louis, pp. 1401-1428.
3. Sartor, R. B. 1997. The influence of normal microbial flora on the development of chronic mucosal inflammation. Res. Immunol. 148:567.
4. Sartor, R. 1998. Postoperative recurrence of Crohn's disease: the enemy is within the fecal stream. Gastroenterology 114:398.
5. Duchmann, R., and M. Zeitz. 1998. Crohn's disease. In Handbook of Mucosal Immunology. P. Ogra and W. Strober, eds. Academic Press, San Diego.
6. Neurath, M. F., S. Finotto, I. Fuss, M. Boirivant, P. R. Galle, and W. Strober. 2001. Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question. Trends Immunol. 22:21.
7. van Deventer, S. J. 2001. Transmembrane TNF-α, induction of apoptosis, and the efficacy of TNF-targeting therapies in Crohn's disease. Gastroenterology 121:1242.
8. ten Hove, T., C. van Montfrans, M. P. Peppelenbosch, and S. J. van Deventer. 2002. Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut 50:206.
9. Parrello, T., G. Monteleone, S. Cucchiara, I. Monteleone, L. Sebkova, P. Doldo, F. Luzza, and F. Pallone. 2000. Up-regulation of the IL-12 receptor β2 chain in Crohn's disease. J. Immunol. 165:7234.
10. Monteleone, G., A. Kumberova, N. M. Croft, C. McKenzie, H. W. Steer, and T. T. MacDonald. 2001. Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease. J. Clin. Invest. 108:601.
11. Glimcher, L. H., and K. M. Murphy. 2000. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14:1693.
12. Murphy, K. M., and S. L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2:933.
13. Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
14. Moser, M., and K. M. Murphy. 2000. Dendritic cell regulation of TH1-TH2 development. Nat. Immunol. 1:199.
15. Targan, S. R., S. B. Hanauer, S. J. van Deventer, L. Mayer, D. H. Present, T. Braakman, K. L. D. Woody, T. F. Schaible, and P. J. Rutgeerts. 1997. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. N. Engl. J. Med. 337:1029.
16. + lamina propria (LP) lymphocyte secretion profiles in inflammatory bowel disease. J. Immunol. 157:1261.
17. Plevy, S. E., C. J. Landers, J. Prehn, N. M. Carramanzana, R. L. Deem, D. Shealy, and S. R. Targan. 1997. A role for TNF-α and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J. Immunol. 159:6276.
18. Breese, E. J., C. A. Michie, S. W. Nicholls, S. H. Murch, C. B. Williams, P. Domizio, J. A. Walker-Smith, and T. T. MacDonald. 1994. Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 106:1455.
19. Breese, E., C. P. Braegger, C. J. Corrigan, J. A. Walker-Smith, and T. T. MacDonald. 1993. Interleukin-2 and interferon-δ secreting T cells in normal and diseased human intestinal mucosa. Immunology 78:127.
20. Mizoguchi, A., E. Mizoguchi, and A. K. Bhan. 1999. The critical role for interleukin-4 but not interferon-δ in the pathogenesis of colitis in T-cell receptor δ mutant mice. Gastroenterology 116:320.
21. Boirivant, M., I. J. Fuss, A. Chu, and W. Strober. 1998. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin-4. J. Exp. Med. 188:1929.
22. + T cells. Immunity 2:553.
23. Neurath, M. F., I. Fuss, B. L. Kelsall, E. Stuber, and W. Strober. 1995. Antibodies to IL-12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1280.
24. Powrie, F., and K. J. Maloy. 2003. Regulating the regulators. Science 299:1030.
25. Ho, I. C., and L. H. Glimcher. 2002. Transcription: tantalizing times for T cells. Cell (Suppl.):S109.
26. Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biologic activities similar as well as distinct from IL-12. Immunity 13:715.
27. Neurath, M. F., B. Weigmann, S. Finotto, J. Glickman, E. Nieuwenhuis, H. Iijima, A. Mizoguchi, E. Mizoguchi, J. Mudter, P. R. Galle, et al. 2002. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 195:1129.
28. + T cells that respond to bacterial antigens. J. Immunol. 162:1884.
29. Ho, I. C., M. R. Hodge, J. W. Rooney, and L. H. Glimcher. 1996. The protooncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85:973.
30. Grimbert, P., A. Valanciute, V. Audard, A. Pawlak, S. Legouvelo, P. Lang, P. Niaudet, A. Bensman, G. Guellaen, and D. Sahali. 2003. Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. J. Exp. Med. 198:797.
31. Ho, I. C., D. Lo, and L. H. Glimcher. 1998. c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J. Exp. Med. 188:1859.
32. Rengarajan, J., and S. J. Szabo. 2000. Transcriptional regulation of Th1/Th2 polarization. Immunol. Today 21:479.
33. Neurath, M. F., S. Finotto, and L. H. Glimcher. 2002. The role of Th1/Th2 polarization in mucosal immunity. Nat. Med. 8:567.
34. Hwang, E. S., I. E. White, and I. C. Ho. 2002. An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines. Proc. Natl. Acad. Sci. USA 99:13026.
35. Atreya, R., J. Mudter, S. Finotto, J. Müllberg, T. Jostock, S. Wirtz, M. Schütz, B. Bartsch, M. Holtmann, C. Becker, et al. 2000. Blockade of IL-6 trans-signaling suppresses T cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn's disease and experimental colitis in vivo. Nat. Med. 6:583.
36. Finotto, S., G. T. D. Sanctis, H. A. Lehr, U. Herz, M. Buerke, M. Schipp, B. Barsch, R. Atreya, E. Schmitt, P. R. Galle, et al. 2001. Treatment of allergic airway inflammation and hyperresponsiveness by local antisense-induced blockade of GATA-3 expression. J. Exp. Med. 193:1247.
37. Asnagli, H., and K. M. Murphy. 2001. Stability and commitment in T helper cell development. Curr. Opin. Immunol. 13:242.
38. Thierfelder, W. E., J. M. vanDeursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. T. Carson, A. K. Abbas, K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
39. Leonard, W. J. 1996. STATs and cytokine specificity. Nat. Med. 2:968.
40. Boirivant, M., R. Pica, R. DeMaria, R. Testi, F. Pallone, and W. Strober. 1996. Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis. J. Clin. Invest. 98:2616.
41. Brande, J. M., H. Braat, G. R. van den Brande, H. H. Versteeg, C. A. Bauer, I. Hoedemaeker, C. van Montfrans, D. W. Hommes, M. P. Peppelenbosch, and S. J. van Deventer. 2003. Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. Gastroenterology 124:1774.
42. Pirzer, U., A. Schonhaar, B. Fleischer, E. Hermann, and K. H. M. z. Buschenfelde. 1991. Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease. Lancet 338:1238.
43. Targan, S. R., R. L. Deem, M. Liu, S. Wang, and A. Nel. 1995. Definition of a lamina propria T cell responsive state: enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J. Immunol. 154:664.
44. Bouma, G., and W. Strober. 2003. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3:521.
45. Neurath, M. F., S. Finotto, and W. Strober. 2001. Immunology of inflammatory bowel disease. In Clinical Immunology, 2nd Ed., Ch. 87. Mosby, St. Louis, p. 21.
46. Burgio, V. L., S. Fais, M. Boirivant, A. Perrone, and F. Pallone. 1995. Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease. Gastroenterology 109:1029.
47. Desreumaux, P., E. Brandt, L. Gambiez, D. Emilie, K. Geboes, O. Klein, N. Ectors, A. Cortot, M. Capron, and J. F. Colombel. 1997. Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease. Gastroenterology 113:118.
48. Rose, M., M. Hildebrandt, H. Fliege, S. Seibold, H. Monnikes, and B. F. Klapp. 2002. T-cell immune parameters and depression in patients with Crohn's disease. J. Clin. Gastroenterol. 34:40.
49. Kirman, I., O. H. Nielsen, E. Kjaersgaard, and J. Brynskov. 1995. Interleukin-2 receptor α and β chain expression by circulating αβ and γδ T cells in inflammatory bowel disease. Dig. Dis. Sci. 40:291.