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Volumn 10, Issue 7, 2004, Pages 473-479

Selective alterations in insulin receptor substrates-1,-2 and -4 in theca but not granulosa cells from polycystic ovaries

Author keywords

Granulosa cell; Insulin receptor substrate; Insulin signalling; PCOS; Theca cell

Indexed keywords

ANDROGEN; HORMONE RECEPTOR STIMULATING AGENT; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INSULIN RECEPTOR SUBSTRATE 4; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P110; UNCLASSIFIED DRUG;

EID: 4344640635     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/gah066     Document Type: Article
Times cited : (37)

References (48)
  • 2
    • 0033304892 scopus 로고    scopus 로고
    • Selective insulin resistance in the polycystic ovary syndrome
    • Book CB and Dunaif A (1999) Selective insulin resistance in the polycystic ovary syndrome. J Clin Endocrinol Metab 84,3110-3116.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3110-3116
    • Book, C.B.1    Dunaif, A.2
  • 3
    • 0026740053 scopus 로고
    • Increased circulating levels of immunoreactive beta-endorphin in polycystic ovary syndrome is not caused by increased pituitary secretion
    • Carmina E, Ditkoff EC, Malizia G, Vijod AG, Janni A and Lobo RA (1992) Increased circulating levels of immunoreactive beta-endorphin in polycystic ovary syndrome is not caused by increased pituitary secretion. Am J Obstet Gynecol 167,1819-1824.
    • (1992) Am. J. Obstet. Gynecol. , vol.167 , pp. 1819-1824
    • Carmina, E.1    Ditkoff, E.C.2    Malizia, G.3    Vijod, A.G.4    Janni, A.5    Lobo, R.A.6
  • 6
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • Dunaif A (1997) Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 18,774-800.
    • (1997) Endocr. Rev. , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 7
    • 0035127474 scopus 로고    scopus 로고
    • Current concepts in the polycystic ovary syndrome
    • Dunaif A and Thomas A (2001) Current concepts in the polycystic ovary syndrome. Annu Rev Med 52,401-419.
    • (2001) Annu. Rev. Med. , vol.52 , pp. 401-419
    • Dunaif, A.1    Thomas, A.2
  • 8
    • 0026699302 scopus 로고
    • Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome
    • Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A and Licholai T (1992) Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41,1257-1266.
    • (1992) Diabetes , vol.41 , pp. 1257-1266
    • Dunaif, A.1    Segal, K.R.2    Shelley, D.R.3    Green, G.4    Dobrjansky, A.5    Licholai, T.6
  • 9
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle
    • Dunaif A, Xia J, Book C, Schenker E and Tang Z (1995) Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. J Clin Invest 96,801-810.
    • (1995) J. Clin. Invest. , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.3    Schenker, E.4    Tang, Z.5
  • 11
    • 0029092780 scopus 로고
    • Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus
    • Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL and Polonsky KS (1995) Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest 96,520-527.
    • (1995) J. Clin. Invest. , vol.96 , pp. 520-527
    • Ehrmann, D.A.1    Sturis, J.2    Byrne, M.M.3    Karrison, T.4    Rosenfield, R.L.5    Polonsky, K.S.6
  • 12
    • 0022085050 scopus 로고
    • The ovarian androgen producing cells: A review of structure/function relationships
    • Erickson GF, Magoffin DA, Dyer CA and Hofeditz C (1985) The ovarian androgen producing cells: a review of structure/function relationships. Endocr Rev 6,371-399.
    • (1985) Endocr. Rev. , vol.6 , pp. 371-399
    • Erickson, G.F.1    Magoffin, D.A.2    Dyer, C.A.3    Hofeditz, C.4
  • 13
    • 0033956283 scopus 로고    scopus 로고
    • Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis
    • Fantin VR, Wang Q, Lienhard GE and Keller SR (2000) Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am J Physiol Endocrinol Metab 278,E127-E133.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.278
    • Fantin, V.R.1    Wang, Q.2    Lienhard, G.E.3    Keller, S.R.4
  • 14
  • 16
    • 84924017867 scopus 로고
    • The polycystic ovary: Clinical and histologic features
    • Goldzieher J and Green J (1962) The polycystic ovary: clinical and histologic features. J Clin Endocrinol 22,325.
    • (1962) J. Clin. Endocrinol. , vol.22 , pp. 325
    • Goldzieher, J.1    Green, J.2
  • 17
    • 0019574818 scopus 로고
    • Insulin receptor: Structure and function
    • Jacobs S and Cuatrecasas P (1981) Insulin receptor: structure and function. Endocr Rev 2,251-263.
    • (1981) Endocr. Rev. , vol.2 , pp. 251-263
    • Jacobs, S.1    Cuatrecasas, P.2
  • 18
    • 0031887465 scopus 로고    scopus 로고
    • Aromatase messenger ribonucleic acid expression in individual follicles from polycystic ovaries
    • Jakimiuk AJ, Weitsman SR, Brzechffa PR and Magoffin DA (1998) Aromatase messenger ribonucleic acid expression in individual follicles from polycystic ovaries. Mol Hum Reprod 4,1-8.
    • (1998) Mol. Hum. Reprod. , vol.4 , pp. 1-8
    • Jakimiuk, A.J.1    Weitsman, S.R.2    Brzechffa, P.R.3    Magoffin, D.A.4
  • 19
    • 0035051203 scopus 로고    scopus 로고
    • Luteinizing hormone receptor, steroidogenesis acute regulatory protein and steroidogenic enzyme messenger ribonucleic acids are over-expressed in theca and granulosa cells from polycystic ovaries
    • Jakimiuk AJ, Weitsman SR, Navab A and Magoffin DA (2001) Luteinizing hormone receptor, steroidogenesis acute regulatory protein and steroidogenic enzyme messenger ribonucleic acids are over-expressed in theca and granulosa cells from polycystic ovaries. J Clin Endocrinol Metab 86, 1318-1323.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 1318-1323
    • Jakimiuk, A.J.1    Weitsman, S.R.2    Navab, A.3    Magoffin, D.A.4
  • 20
    • 0021904906 scopus 로고
    • The molecular mechanism of insulin action
    • Kahn CR (1985) The molecular mechanism of insulin action. Annu Rev Med 36,429-451.
    • (1985) Annu. Rev. Med. , vol.36 , pp. 429-451
    • Kahn, C.R.1
  • 21
    • 0030848782 scopus 로고    scopus 로고
    • A novel 160kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family
    • Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR and Lienhard GE (1997a) A novel 160kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. J Biol Chem 272,21403-21407.
    • (1997) J. Biol. Chem. , vol.272 , pp. 21403-21407
    • Lavan, B.E.1    Fantin, V.R.2    Chang, E.T.3    Lane, W.S.4    Keller, S.R.5    Lienhard, G.E.6
  • 22
    • 0030995946 scopus 로고    scopus 로고
    • The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family
    • Lavan BE, Lane WS and Lienhard GE (1997b) The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J Biol Chem 272,11439-11443.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11439-11443
    • Lavan, B.E.1    Lane, W.S.2    Lienhard, G.E.3
  • 23
    • 0031787388 scopus 로고    scopus 로고
    • A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome
    • Legro RS, Finegood D and Dunaif A (1998) A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 83,2694-2698.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2694-2698
    • Legro, R.S.1    Finegood, D.2    Dunaif, A.3
  • 24
    • 0024230884 scopus 로고
    • Steroidogenesis in human polycystic ovary
    • Mahajan DK (1988) Steroidogenesis in human polycystic ovary. Endocrinol Metab Clin N Am 17,751-769.
    • (1988) Endocrinol. Metab. Clin. N. Am. , vol.17 , pp. 751-769
    • Mahajan, D.K.1
  • 25
    • 0027941991 scopus 로고
    • Severe impairment of insulin action in adipocytes from amenorrheic subjects with polycystic ovary syndrome
    • Marsden PJ, Murdoch A and Taylor R (1994) Severe impairment of insulin action in adipocytes from amenorrheic subjects with polycystic ovary syndrome. Metabolism 43,1536-1542.
    • (1994) Metabolism , vol.43 , pp. 1536-1542
    • Marsden, P.J.1    Murdoch, A.2    Taylor, R.3
  • 26
    • 0034825343 scopus 로고    scopus 로고
    • Tissue insulin sensitivity and body weight in polycystic ovary syndrome
    • Marsden PJ, Murdoch AP and Taylor R (2001) Tissue insulin sensitivity and body weight in polycystic ovary syndrome. Clin Endocrinol (Oxf) 55, 191-199.
    • (2001) Clin. Endocrinol. (Oxf) , vol.55 , pp. 191-199
    • Marsden, P.J.1    Murdoch, A.P.2    Taylor, R.3
  • 27
    • 0029079779 scopus 로고
    • Insulin resistant and non-resistant polycystic ovary syndrome represent two clinical and endocrinological subgroups
    • Meirow D, Yossepowitch O, Rosler A, Brzezinski A, Schenker JG, Laufer N and Raz I (1995) Insulin resistant and non-resistant polycystic ovary syndrome represent two clinical and endocrinological subgroups. Hum Reprod 10,1951-1956.
    • (1995) Hum. Reprod. , vol.10 , pp. 1951-1956
    • Meirow, D.1    Yossepowitch, O.2    Rosler, A.3    Brzezinski, A.4    Schenker, J.G.5    Laufer, N.6    Raz, I.7
  • 28
    • 0346458803 scopus 로고    scopus 로고
    • Insulin stimulation of 17α-hydroxylase activity is mediated by phosphatidylinositol 3-kinase but not ERK1/2 in human ovarian theca cells
    • Munir I, Yen HW, Geller DH, Torbati D, Bierden R, Weitsman SR, Agarwal SK and Magoffin DA (2004) Insulin stimulation of 17α-hydroxylase activity is mediated by phosphatidylinositol 3-kinase but not ERK1/2 in human ovarian theca cells. Endocrinology 145,175-183.
    • (2004) Endocrinology , vol.145 , pp. 175-183
    • Munir, I.1    Yen, H.W.2    Geller, D.H.3    Torbati, D.4    Bierden, R.5    Weitsman, S.R.6    Agarwal, S.K.7    Magoffin, D.A.8
  • 29
    • 0029796476 scopus 로고    scopus 로고
    • Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome
    • Nestler JE and Jakubowicz DJ (1996) Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. N Engl J Med 335,617-623.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 617-623
    • Nestler, J.E.1    Jakubowicz, D.J.2
  • 30
    • 0031790832 scopus 로고    scopus 로고
    • Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositol glycan mediators as the signal transduction system
    • Nestler JE, Jakubowicz DJ, de Vargas AF, Brik C, Quintero N and Medina F (1998) Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositol glycan mediators as the signal transduction system. J Clin Endocrinol Metab 83,2001-2005.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2001-2005
    • Nestler, J.E.1    Jakubowicz, D.J.2    de Vargas, A.F.3    Brik, C.4    Quintero, N.5    Medina, F.6
  • 31
    • 0023879442 scopus 로고
    • Polycystic ovaries - A common finding in normal women
    • Polson DW, Adams J, Wadsworth J and Franks S (1988) Polycystic ovaries - a common finding in normal women. Lancet i,870-872.
    • (1988) Lancet , vol.1 , pp. 870-872
    • Polson, D.W.1    Adams, J.2    Wadsworth, J.3    Franks, S.4
  • 32
    • 0020702372 scopus 로고
    • Insulin receptor: Evidence that it is a protein kinase
    • Roth RA and Cassell DJ (1983) Insulin receptor: evidence that it is a protein kinase. Science 219,299-301.
    • (1983) Science , vol.219 , pp. 299-301
    • Roth, R.A.1    Cassell, D.J.2
  • 33
    • 0030730246 scopus 로고    scopus 로고
    • Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene
    • Sciachitano S and Taylor SI (1997) Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene. Endocrinology 138, 4931-4940.
    • (1997) Endocrinology , vol.138 , pp. 4931-4940
    • Sciachitano, S.1    Taylor, S.I.2
  • 34
    • 0034810894 scopus 로고    scopus 로고
    • Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
    • Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P and Lauro R (2001) Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J 15,2099-2111.
    • (2001) FASEB J. , vol.15 , pp. 2099-2111
    • Sesti, G.1    Federici, M.2    Hribal, M.L.3    Lauro, D.4    Sbraccia, P.5    Lauro, R.6
  • 40
    • 0034750801 scopus 로고    scopus 로고
    • Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling
    • Tsuruzoe K, Emkey R, Kriauciunas KM, Ueki K and Kahn CR (2001) Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling. Mol Cell Biol 21,26-38.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 26-38
    • Tsuruzoe, K.1    Emkey, R.2    Kriauciunas, K.M.3    Ueki, K.4    Kahn, C.R.5
  • 41
    • 0033988375 scopus 로고    scopus 로고
    • IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis
    • Uchida T, Myers MG, Jr and White MF (2000) IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis. Mol Cell Biol 20,126-138.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 126-138
    • Uchida, T.1    Myers Jr., M.G.2    White, M.F.3
  • 42
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • Velazquez EM, Mendoza S, Hamer T, Sosa F and Glueck CJ (1994) Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 43,647-654.
    • (1994) Metabolism , vol.43 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 43
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K and Kahn CR (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103,931-943.
    • (1999) J. Clin. Invest. , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 44
    • 0030780254 scopus 로고    scopus 로고
    • The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
    • White MF and Yenush L (1998) The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Curr Top Microbiol Immunol 228,179-208.
    • (1998) Curr. Top. Microbiol. Immunol. , vol.228 , pp. 179-208
    • White, M.F.1    Yenush, L.2
  • 45
    • 0034457443 scopus 로고    scopus 로고
    • Differential activity of the cytochrome P450 17α-hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells
    • Wickenheisser JK, Quinn PG, Nelson VL, Legro RS, Strauss JF, III and McAllister JM (2000) Differential activity of the cytochrome P450 17α-hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells. J Clin Endocrinol Metab 58,2304-2311.
    • (2000) J. Clin. Endocrinol. Metab. , vol.58 , pp. 2304-2311
    • Wickenheisser, J.K.1    Quinn, P.G.2    Nelson, V.L.3    Legro, R.S.4    Strauss III, J.F.5    McAllister, J.M.6
  • 46
    • 0028823250 scopus 로고
    • Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin-like growth factor receptor
    • Willis D and Franks S (1995) Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin-like growth factor receptor. J Clin Endocrinol Metab 80,3788-3790.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 3788-3790
    • Willis, D.1    Franks, S.2
  • 48
    • 0033835617 scopus 로고    scopus 로고
    • Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls
    • Wu X, Sallinen K, Anttila L, Makinen M, Luo C, Pollanen P and Erkkola R (2000) Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls. Fertil Steril 74,564-572.
    • (2000) Fertil. Steril. , vol.74 , pp. 564-572
    • Wu, X.1    Sallinen, K.2    Anttila, L.3    Makinen, M.4    Luo, C.5    Pollanen, P.6    Erkkola, R.7


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