Jaks and Stats in cytokine signaling

Stem Cells

Volumn 15, Issue SUPPL. 1, 1997, Pages 105-112

  Ihle, James N ^a   Nosaka, Tetsuya ^a   Thierfelder, William ^a   Quelle, Frederick W ^a   Shimoda, Kazuya ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Cytokines; Gene transcription; Janus kinase; Signal transduction; Stats; Tyrosine kinases

Indexed keywords

ERYTHROPOIETIN; INTERLEUKIN 12; INTERLEUKIN 4;

CONFERENCE PAPER; DIMERIZATION; ENZYME ACTIVITY; IMMUNE RESPONSE; LIGAND BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYTOKINES; DNA-BINDING PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

JANUS;

EID: 0030704646     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.5530150814     Document Type: Article

References (48)

1. Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990;87:6934-6938.
2. De Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 1992;255:306-312.
3. Youssoufian H, Longmore G, Neumann D et al. Structure, function, and activation of the erythropoietin receptor. Blood 1993;9:2223-2236.
4. D'Andrea AD, Yoshimura A, Youssoufian H et al. The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains. Mol Cell Biol 1991;11:1980-1987.
5. Witthuhn B, Quelle FW, Silvennoinen O et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following EPO stimulation. Cell 1993;74:227-236.
6. 1007 in the kinase activation loop. Mol Cell Biol 1997 (in press).
7. Miura Y, Miura O, Ihle JN et al. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J Biol Chem 1994;269:29962-29969.
8. Ren HY, Komatsu N, Shimizu R et al. Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line. J Biol Chem 1994;269:19633-19638.
9. Miura O, Nakamura N, Ihle JN et al. Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor. J Biol Chem 1994;269:614-620.
10. Yi T, Zhang J, Miura O et al. Hematopoietic cell phosphatase (HCP) associates with the erythropoietin receptor following Epo induced receptor tyrosine phosphorylation: identification of potential binding sites. Blood 1995;85:87-95.
11. Shultz LD, Schweitzer PA, Rajan TV et al. Mutations at the murine motheaten locus are within the hematopoietic cell protein tyrosine phosphatase (Hcph) gene. Cell 1993;73:1445-1454.
12. Klingmuller U, Lorenz U, Cantly LC et al. Specific recruitment of the hematopoietic protein tyrosine phosphatase SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 1995;80:729-738.
13. Azam M, Erdjument-Bromage H, Kreider B et al. Purification of interleukin-3 stimulated DNA binding factors demonstrates the involvement of multiple isoforms of Stat5 in signaling. EMBO J 1995;14:1402-1411.
14. Copeland NG, Gilbert DJ, Schindler C et al. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics 1995;29:225-228.
15. Gobert S, Chretien S, Gouilleux F et al. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. EMBO J 1996;15:2434-2441.
16. Klingmuller U, Bergelson S, Hsiao JG et al. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5. Proc Natl Acad Sci USA 1996;93:8324-8328.
17. Quelle BV, Wang D, Nosaka T et al. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 1996;16:1622-1631.
18. Damen JE, Wakao H, Miyajima A et al. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J 1995;14:5557-5568.
19. Mui A-F, Wakao H, Kinoshita T et al. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J 1996;15:2425-2433.
20. Witthuhn BA, Silvennoinen O, Miura O et al. Involvement of the JAK3 Janus kinase in IL-2 and IL-4 signalling in lymphoid and myeloid cells. Nature 1994;370:153-157.
21. Johnston JA, Kawamura M, Kirken R et al. Phosphorylation and activation of the JAK3 Janus kinase in response to IL-2. Nature 1994;370:151-153.
22. Miyazaki T, Kawahara A, Fujii H et al. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 1994;266:1045-1047.
23. Nosaka T, van Deursen JMA, Tripp R et al. Defective lymphoid development in mice lacking Jak3. Science 1995;270:800-802.
24. Thornis DC, Gurniak CB, Tivol E et al. Mice lacking Jak3 have defects in B lymphocyte maturation and T lymphocyte activation. Science 1995;270:794-797.
25. Macchi P, Villa A, Giliani S et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995;377:65-68.
26. Russell SM, Tayebi N, Nakajima H et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995;270:797-800.
27. von Freeden-Jeffry U, Vieria P, Lucian LA et al. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 1995;181:1519-1526.
28. Peschon JJ, Morrissey PJ, Grabstein KH et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994;180:1955-1960.
29. Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-1421.
30. Meraz MA, White JM, Sheehan KCF et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996;84:431-442.
31. Durbin JE, Hackenmiller R, Simon MC et al. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996;84:443-450.
32. Akira S, Nishio Y, Inoue M et al. Molecular cloning of APRF, a novel ISGF3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 1994;77:63-71.
33. Zhong Z, Wen Z, Darnell JEJ. Stat3: a new family member that is activated through tyrosine phosphorylation in response to EGF and IL-6. Science 1994;264:95-98.
34. Zhong Z, Wen Z, Darnell JEJ. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA 1994;91:4806-4810.
35. Yamamoto K, Quelle FW, Thierfelder WE et al. Stat4: a novel GAS binding protein expressed in early myeloid differentiation. Mol Cell Biol 1994;14:4342-4349.
36. Liu X, Robinson GW, Gouilleux F et al. Cloning and expression of Stat5 and an additional hemologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA 1995;92:8831-8835.
37. Wakao H, Gouilleux F, Groner B. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J 1994;13:2182-2191.
38. Quelle BV, Shimoda K, Thierfelder W et al. Cloning of murine and human Stat6 (IL-4 Stat): a novel stat tyrosine phosphorylated in the responses to IL-4 and IL-3 that is not required for mitosenesis. Mol Cell Biol 1995;15:3336-3343.
39. Hou J, Schindler U, Henzel WJ et al. An interleukin-4-induced transcription factor: IL-4 stat. Science 1994;265:1701-1706.
40. Jacobson NG, Szabo S, Weber-Nordt RM et al. Interleukin 12 activates Stat3 and Stat4 by tyrosine phosphorylation in T cells. J Exp Med 1995;181:1755-1762.
41. Thierfelder WE, van Deursen J, Yamamoto K et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996;382:171-174.
42. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995;13:251-276.
43. Shimoda K, van Deursen J, Sangster MY et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996;380:630-633.
44. Takeda K, Tanaka T, Shi W et al. Essential role of Stat6 in IL-4 signalling. Nature 1996;380:627-630.
45. Kaplan MH, Schindler U, Smiley ST et al. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 1996;4:313-319.
46. Delphin S, Stavnezer J. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline ε promoter: regulation by NF-IL-4, a C/EBP family member and NF-kB/p50. J Exp Med 1995;181:181-192.
47. Rothman P, Li SC, Gorham B et al. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line E transcripts. Mol Cell Biol 1991;11:5551-5561.
48. Binari R, Perrimon N. Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev 1994;8:300-312.