Comparative genomic hybridization analysis of astrocytomas: Prognostic and diagnostic implications

Journal of Molecular Diagnostics

Volumn 6, Issue 3, 2004, Pages 166-179

  Wiltshire, Rodney N ^a   Herndon II, James E ^a   Lloyd, Annie ^a   Friedman, Henry S ^a   Bigner, Darell D ^a   Bigner, Sandra H ^a   McLendon, Roger E ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; ONCOPROTEIN; TUMOR SUPPRESSOR PROTEIN;

ADULT; ARTICLE; ASTROCYTOMA; CANCER DIAGNOSIS; CANCER GRADING; CANCER MORTALITY; CHROMOSOME 10; CHROMOSOME 10Q; CHROMOSOME 19; CHROMOSOME 19P; CHROMOSOME 20; CHROMOSOME 22; CHROMOSOME 7; CHROMOSOME 7Q; CHROMOSOME 9P; CHROMOSOME LOSS; CLINICAL LABORATORY; COMPARATIVE GENOMIC HYBRIDIZATION; DNA SEQUENCE; GENE IDENTIFICATION; GENE LOCUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NONBIOLOGICAL MODEL; ONCOGENE; PROGNOSIS; RISK ASSESSMENT; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; TUMOR SUPPRESSOR GENE;

EID: 4344627154     PISSN: 15251578     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1525-1578(10)60507-7     Document Type: Article

References (68)

1. Berger MS, Leibel SA, Bruner JM, Finlay JL, Levin VA: Primary cerebral tumors. Cancer in the Nervous System, ed 2. Edited by Levin VA. New York, Oxford University Press, 2002, pp 75-148
2. Kleihues P, Cavenee WK: Pathology and genetics of tumors of the nervous system. World Health Organization Classification of Tumors, ed 2. Lyon, International Agency for Research on Cancer, 2000
3. Burger PC, Green SB: Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer 1987, 59: 1617-1625
4. Bruner JM, Inouye L, Fuller GN, Langford LA: Diagnostic discrepancies and their clinical impact in a neuropathology referral practice. Cancer 1997, 79:796-803
5. Coons SW, Johnson PC, Scheithauer BW, Yates AJ, Pearl DK: Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas. Cancer 1997, 79:1381-1393
6. Bigner SH, Batra SK, Rasheed BKA: Mechanisms of altered growth control: cytogenetics, oncogenes, and suppressor genes. Russell and Rubinstein's Pathology of Tumors of the Nervous System, ed 6. Edited by Bigner DD, McLendon RE, Bruner JM. New York, Oxford University Press, 1998, vol 1, pp 47-82
7. Collins VP: Progression as exemplified by human astrocytic tumors. Semin Cancer Biol 1999, 9:267-276
8. Bigner SH, Mark J, Bigner DD: Cytogenetics of human brain tumors. Cancer Genet Cytogenet 1990, 47:141-154
9. Wiltshire RN, Rasheed BKA, Friedman HS, Friedman AH, Bigner SH: Comparative genetic patterns of glioblastoma multiforme: potential diagnostic tool for tumor classification. Neuro-Oncol 2000, 2:164-173
10. Burton EC, Lamborn KR, Feuerstein BG, Prados M, Scott J, Forsyth P, Passe S, Jenkins RB, Aldape KD: Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma. Cancer Res 2002, 62:6205-6210
11. Rasheed A, Herndon JE, Stenzel TT, Raetz JGM, Kendelhardt J, Friedman HS, Friedman AH, Bigner DD, Bigner SH, McLendon RE: Molecular markers of prognosis in astrocytic tumors. Cancer 2002, 94:2688-2697
12. Reavey-Cantwell JF, Haroun RI, Zahurak M, Clatterbuck RE, Parker RJ, Mehta R, Fruehauf JP, Brem H: The prognostic value of tumor markers in patients with glioblastoma multiforme: analysis of 32 patients and review of the literature. J Neuro-Oncol 2001, 55:195-204
13. Smith JS, Tachibana I, Passe SM, Huntley BK, Borell TJ, Iturria N, O'Fallon JR, Schaefer PL, Scheithauer BW, James CD, Buckner JC, Jenkins RB: PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J Natl Cancer Inst 2001, 93:1246-1256
14. Kunwar S, Mohapatra G, Bollen A, Lamborn KR, Prados M, Feuerstein BG: Genetic subgroups of anaplastic astrocytomas correlate with patient age and survival. Cancer Res 2001, 61:7683-7688
15. Leenstra S, Oskam NT, Bijleveld EH, Bosch DA, Troost D, Hulsebos TJM: Genetic sub-types of human malignant astrocytomas correlate with survival. Int J Cancer 1998, 79:159-165
16. Cianciulli AM, Morace E, Colette AM, Occhipinti E, Gandolfo GM, Leonardo G, Carapella CM: Investigation of genetic alterations associated with development and adverse outcome in patients with astrocytic tumor. J Neurol-Oncol 2000, 48:95-101
17. Koschny R, Koschny T, Froster UG, Krupp W, Zuber MA: Comparative genomic hybridization in glioma: a meta-analysis of 509 cases. Cancer Genet Cytogenet 2002, 135:147-159
18. Bigner SH, Matthews MR, Rasheed BKA, Wiltshire RN, Friedman HS, Friedman AH, Stenzel TT, Dawes DM, McLendon RE, Bigner DD: Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization. Am J Pathol 1999, 155:375-386
19. Schmidt MC, Antweiler S, Urban N, Mueller W, Kulklik A, Meyer-Puttlitz B, Wiestler OD, Louis DN, Fimmers R, von Deimling A: Impact of genotype and morphology on the prognosis of glioblastoma. J Neuropathol Exp Neurol 2002, 61:321-328
20. Sanoudou D, Tingloy O, Ferguson-Smith MA, Collins VP, Coleman N: Analysis of pilocytic astrocytomas by comparative genomic hybridization. Br J Cancer 2000, 82:1218-1222
21. Schröck E, Thiel G, Lozanova T, du Manoir S, Meffert M-C, Jauch A, Speicher MR, Nürnberg P, Vogel S, Jänisch W, Donis-Keller H, Ried T, Witkowski R, Cremer T: Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses. Am J Pathol 1994, 144: 1203-1218
22. Nishizaki T, Ozaki S, Harada K, Ito H, Arai H, Beppu T, Sasaki K: Investigation of genetic alterations associated with the grade of astrocytic tumor by comparative genomic hybridization. Genes Chromosomes Cancer 1998, 21:340-346
23. Weber RG, Sabel M, Reifenberger J, Sommer C, Oberstraß J, Reifenberger G, Kiessling M, Cremer T: Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization. Oncogene 1996, 13:983-994
24. Heimberger AB, Wiltshire RN, Bronec R, McLendon RE, Cummings TJ: Biphasic malignant meningiomas: a comparative genomic hybridization study. Clin Neuropathol 2002, 21:258-264
25. Desper R, Jiang F, Kallioniemi O-P, Moch H, Papadimitriou CH, Schäffer AA: Inferring tree models for oncogenesis from comparative genome hybridization data. J Comput Biol 1999, 6:37-51
26. Simon R, Desper R, Papadimitriou CH, Peng A, Alberts DS, Taetle R, Trent JM, Schäffer AA: Chromosome abnormalities in ovarian adenocarcinoma: ill. Using breakpoint data to infer and test mathematical models for oncogenesis. Genes Chromosome Cancer 2000, 28:106-120
27. Brodeur GM, Tsiatis AA, Williams DL, Luthardt FW, Green AA: Statistical analysis of cytogenetic abnormalities in human cancer cells. Cancer Genet Cytogenet 1982, 7:137-152
28. McLendon RE, Robinson Jr JS, Chambers DB, Grufferman S, Burger PC: The glioblastoma multiforme in Georgia, 1977-1981. Cancer 1985, 56:894-897
29. Ganju V, Jenkins RB, O'Fallon JR, Scheithauer BW, Ransom DT, Katzmann JA, Kimmel DW: Prognostic factors in gliomas: a multivariate analysis of clinical, pathologic, flow cytometric, cytogenetic, and molecular markers. Cancer 1994, 74:920-927
30. Kraus JA, Glesmann N, Beck M, Krex D, Klockgether T, Schackert G, Schlegel U: Molecular analysis of the PTEN, TP53 and CDKN2A tumor suppressor genes in long-term survivors of glioblastoma multiforme. J Neuro-Oncol 2000, 48:89-94
31. James CD, Galanis E, Frederick L, Kimmel DW, Cummingham JM, Atherton-Skaff PJ, O'Fallon JR, Jenkins RB, Buckner JC, Hunter SB, Olson JJ, Scheithauer BW: Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation. Int J Oncol 1999, 15:547-553
32. von Deimling A, Fimers R, Schmidt MC, Bender B, Fassbender F, Nagel J, Jahnke R, Kaskel P, Duerr E-M, Koopmann J, Maintz D, Steinbeck S, Wick W, Platten M, Müller DJ, Przkora R, Waha A, Blümcke B, Wellenreuther R, Meyer-Puttlitz B, Schmidt O, Molienhauer J, Poustka A, Stangl AP, Lenartz D, von Ammon K, Henson JW, Schramm J, Louis DN, Wiestler OD: Comprehensive allelotype and genetic analysis 466 human nervous system tumors. J Neuropathol Exp Neurol 2000, 59:544-558
33. Ichimura K, Schmidt EE, Miyakawa A, Goike HM, Collins VP: Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. Genes Chromosomes Cancer 1998, 22:9-15
34. Mollenhauer J, Holmskov U, Wiemann S, Krebs I, Herbertz S, Madsen J, Kioschis P, Coy JF, Poustka A: The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability. Oncogene 1999, 18:6233-6240
35. Fujisawa H, Kurrer M, Reis RM, Yonekawa Y, Kleihues P, Ohgaki H: Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozgosity on 10q25-qter. Am J Pathol 1999, 155:387-394
36. Fujisawa H, Reis RM, Nakamura M, Colella S, Yonekawa Y, Kleihues P, Ohgaki H: Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas. Lab Invest 2000, 80:65-72
37. Mohapatra G, Bollen AW, Kim DH, Lamborn K, Moore DH, Prados MD, Feuerstein BG: Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade. Genes Chromosomes Cancer 1998, 21:195-206
38. Albarosa R, Finocchiaro G, Chiariello E, Russo G, Susani L, Vezzoni P, Zucchi I: Construction of a 5-Mb YAC contig from the putative 10q25 tumor-suppressor region for glioblastomas. Genomics 1997, 41:345-349
39. Rasheed BKA, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD, Bigner SH: Chromosome 10 deletion mapping in human glomas: a common deletion region in 10q25. Oncogene 1995, 10: 2243-2246
40. Wechsler DS, Shelly CA, Petroff CA, Dang CV: MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells. Cancer Res 1997, 57:4905-4912
41. Albarosa R, DiDonato S, Finocchiaro G: Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3′ non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. Hum Genet 1995, 95:709-711
42. Kimmelman AC, Ross DA, Liang BC: Loss of heterozygosity of chromosome 10p in human gliomas. Genomics 1996, 34:250-254
43. Voesten AMJ, Bijleveld EH, Westerveld A, Hulsebos TJM: Fine mapping of a region of common deletion on chromosome arm 10p in human glioma. Genes Chromosomes Cancer 1997, 20:167-172
44. Smith JS, Tachibana I, Lee HK, Qian J, Pohl U, Mohrenweiser HM, Borell TJ, Hosek SM, Soderberg CL, von Deimling A, Perry A, Scheithauer BW, Louis DN, Jenkins RB: Mapping of the chromosome 19q-arm glioma tumor suppressor gene using fluorescence in situ hybridization and novel microsatellite markers. Genes Chromosomes Cancer 2000, 29:16-25
45. von Deimling A, Bender B, Jahnke R, Waha A, Kraus J, Albrecht S, Wellenreuther R, Fassbender F, Nagel J, Menon AG: Loci associated with malignant progression in astrocytomas: a candidate on chromosome 19q. Cancer Res 1994, 54:1397-1401
46. Kraus JA, Koopmann J, Kaskel P, Maintz D, Brandner S, Schramm J, Louis DN, Wiestler OD, von Deimling A: Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. J Neuropathol Exp Neurol 1995, 54: 91-95
47. Smith JS, Perry A, Borell TJ, Lee HK, O'Fallon J, Hosek SM, Kimmel D, Yates A, Burger PC, Scheithauer BW, Jenkins RB: Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol 2000, 18:636-645
48. Ino Y, Betensky RA, Zlatescu MC, Sasaki H, Macdonald DR, Stemmer-Rachamimov AO, Ramsay DA, Cairncross JG, Louis DN: Molecular subtypes of analplastic oligodendroglioma: implications for patient management at diagnosis. Clin Cancer Res 2001, 7:839-845
49. Ino Y, Zlatescu MC, Sasaki H, Macdonald DR, Stemmer-Rachamimov AO, Jhung S, Ramsay DA, von Deimling A, Louis DN, Cairncross JG: Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss. J Neurosurg 2000, 92:983-990
50. Oskam NT, Bijleveld EH, Hulsebos TJM: A region of common deletion in 22q13.3 in human glioma associated with astrocytoma progression. Int J Cancer 2000, 85:336-339
51. Ino Y, Silver JS, Blazejewski L, Nishikawa R, Matsutani M, von Deimling A, Louis DN: Common regions of deletion on chromosome 22q12.3-q13.1 and 22q13.2 in human astrocytomas appear related to malignancy grade. J Neuropathol Exp Neurol 1999, 58:881-885
52. Grimmond S, Larder R, Van Hateren N, Siggers P, Hulsebos TJM, Arkell R, Greenfield A: Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). Genomics 2000, 70:74-81
53. Zhang Y, Cai X, Schlegelberger B, Zheng S: Assignment of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24->q25 by in situ hybridization. Cytogenet Cell Genet 1998, 83:56-57
54. Wessels PH, Twijnstra A, Kessels AGH, Krijne-Kubat B, Theunissen PH, Ummelen MIJ, Ramaekers FCS, Hopmam AH: Gain of chromosome 7, as detected by in situ hybridization, strongly correlates with shorter survival in astrocytoma grade 2. Genes Chromosomes Cancer 2002, 33:279-284
55. Liu L, Ichimura K, Pettersson EH, Goike HM, Collins VP: The complexity of the 7p12 amplicon in human astrocytic gliomas: detailed mapping of 246 tumors. J Neuropathol Exp Neurol 2000, 59:1087-1093
56. Bigner SH, Humphrey PA, Wong AJ, Vogelstein B, Mark J, Friedman HS, Bigner DD: Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. Cancer Res 1990, 50:8017-8022
57. Rainov NG, Dobberstein K-U, Bahn H, Holzhausen H-J, Lautenschläger C, Heidecke V, Burkert W: Prognostic factors in malignant glioma: influence of the overexpression of oncogene and tumor-suppressor gene products on survival. J Neuro-Oncol 1997, 35: 13-28
58. Olson JJ, Barnett D, Yang J, Assietti R, Cotsonis G, James CD: Gene amplification as a prognostic factor in primary brain tumors. Clin Cancer Res 1998, 4:215-222
59. Morita M, Rosenblum MK, Bilsky MH, Fraser RAR, Rosenfeld MR: Long-term survivors of glioblastoma multiforme: clinical and molecular characteristics. J Neuro-Oncol 1996, 27:259-266
60. Huncharek M, Kupelnick B: Epidermal growth factor receptor gene amplification as a prognostic marker in glioblastoma multiforme: results of a meta-analysis. Oncol Res 2000, 12:107-112
61. Bigner SH, Burger PC, Wong AJ, Werner MH, Hamilton SR, Muhlbaier LH, Vogelstein B, Bigner DD: Gene amplification in malignant human gliomas: clinical and histopathologic aspects. J Neuropathol Exp Neurol 1988, 47:191-205
62. Jaros E, Perry RH, Adam L, Kelly PJ, Crawford PJ, Kalbag RM, Mendelow AD, Sengupta RP, Pearson ADJ: Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours. Br J Cancer 1992, 66:373-385
63. Korkolopoulou P, Christodoulou P, Kouzelis K, Hadjiyannakis M, Priftis A, Stamoulis G, Seretis A, Thomas-Tsagli E: MDM2 and p53 expression in gliomas: a multivariate survival analysis including proliferation markers and epidermal growth factor receptor. Br J Cancer 1997, 75:1269-1278
64. Simmons ML, Lamborn KR, Takahashi M, Chen P, Israel MA, Berger MS, Godfrey T, Nigro J, Prados M, Chang S, Barker FG II, Aldape K: Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients. Cancer Res 2001, 61:1122-1128
65. Paunu N, Sallinen S-L, Karhu R, Miettinen H, Sallinen P, Kononen J, Laippala P, Simola KOJ, Helén P, Haapasalo H: Chromosome imbalances in familial gliomas detected by comparative genomic hybridization. Genes Chromosomes Cancer 2000, 29:339-346
66. Brunner C, Jung V, Henn W, Zang KD, Urbschat S: Comparative genomic hybridization reveals recurrent enhancements on chromosome 20 and in one case combined amplification sites on 15q24q26 and 20p11p12 in glioblastomas. Cancer Genet Cytogenet 2000, 121: 124-127
67. Weber RG, Sommer C, Albert FK, Kiessling M, Cremer T: Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization. Lab Invest 1996, 74:108-119
68. Schlegel J, Scherthan H, Arens N, Stumm G, Kiessling M: Detection of complex genetic alterations in human glioblastoma multiforme using comparative genomic hybridization. J Neuropathol Exp Neurol 1996, 55:81-87