Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium

Molecular Human Reproduction

Volumn 10, Issue 8, 2004, Pages 567-572

  Lahav Baratz, Shirly ^a   Ben Izhak, O ^b   Sabo, E ^a   Ben Eliezer, S ^b   Lavie, O ^a   Ishai, D ^a   Ciechanover, A ^b   Dirnfeld, M ^a  

^a CARMEL MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Endometrium; IVF; Ovarian hyperstimulation; p27; Ubiquitin

Indexed keywords

BIOLOGICAL MARKER; BUSERELIN; CHORIONIC GONADOTROPIN; CYCLIN DEPENDENT KINASE INHIBITOR; ESTROGEN; HUMAN MENOPAUSAL GONADOTROPIN; KI 67 ANTIGEN; PROGESTERONE; PROTEASOME; PROTEIN P27; REGULATOR PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN; UBIQUITIN PROTEIN LIGASE;

ADULT; AGED; ARTICLE; CANCER PATIENT; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MEGADOSE; ENDOMETRIUM CARCINOMA; FEMALE; FERTILIZATION IN VITRO; HUMAN; HUMAN TISSUE; OVARY HYPERSTIMULATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RISK FACTOR; STATISTICAL SIGNIFICANCE; UBIQUITINATION;

BIOPSY; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; FERTILIZATION IN VITRO; HUMANS; KI-67 ANTIGEN; OVARIAN HYPERSTIMULATION SYNDROME; OVULATION INDUCTION; RISK FACTORS; S-PHASE KINASE-ASSOCIATED PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 4344607584     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/gah084     Document Type: Article

References (24)

1. Bamberger AM, Riethdorf L, Milde-Langosch K, Bamberger CM, Thuneke I, Erdmann I, Schulte HM and Loning T (1999) Strongly reduced expression of the cell cycle inhibitor p27 in endometrial neoplasia. Virchows Arch 434,423-428.
2. Bebington C, Doherty FJ, Ndukwe G and Fleming SD (2000) The progesterone receptor and ubiquitin are differentially regulated within the endometrial glands of the natural and stimulated cycle. Mol Hum Reprod 6,264-268.
3. Carrano AC, Eytan E, Hershko A and Pagano M (1999) Skp2 is required for ubiquitin-mediated degradation of the Cdk inhibitor p27. Nat Cell Biol 1, 193-196.
4. Dai D, Wolf DM, Litman ES, White MJ and Leslie KK (2002) Progesterone inhibits human endometrial cancer cell growth and invasiveness. Cancer Res 62,881-886.
5. Deashies R (1999) SCF and Cullin/Ring H2 based ubiquitin ligases. Annu Rev Cell Dev Biol 15,435-448.
6. Dirnfeld M, Goldman S, Gonen Y, Koifman M, Lissak A, Kraiem Z and Abramovici H (1993) Functional differentiation in progesterone secretion by granulose versus cumulus cells in the human preovulatory follicle and the effect of different induction of ovulation. protocols. Fertil Steril 60, 1025-1030.
7. Glickman MH and Ciechanover A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82,373-428.
8. Hershko D, Bornstein G, Ben-Izhak O, Carrano A, Pagano M, Krausz MM and Hershko A (2001) Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. Cancer 91, 1745-1751.
9. Illouz S, Dales JP, Sferlazzo K, Garcia S, Carpentier-Meunier S, Boubli L, Lavaut MN and Charpin C (2003) Effects of progestins of human proliferative endometrium: an in vitro model of potential clinical relevance. Int J Mol Med 12,517-523.
10. Lerner-Geva L, Geva E, Lessing JB, Chetrit A, Modan B and Amit A (2003) The possible association between in vitro fertilization treatments and cancer development. Int J Gynecol Cancer 13,23-27.
11. Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM and Pagano M (1997) Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 3,231-234.
12. Oshita T, Shigemasa K, Nagai N and Ohama K (2002) p27, cyclin E, and CDK2 expression in normal and cancerous endometrium. Int J Oncol 21, 737-743.
13. Sherr CJ and Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13,1501-1512.
14. Shiozawa T, Nikaido T, Nakayama K, Lu X and Fujii S (1998) Involvement of cyclin-dependent kinase inhibitor p27Kip1 in growth inhibition of endometrium in the secretory phase and of hyperplastic endometrium treated with progesterone. Mol Hum Reprod 4,899-905.
15. Shiozawa T, Horiuchi A, Kato K, Obinata M, Konishi I, Fujii S and Nikaido T (2001) Up-regulation of p27Kip1 by progestins is involved in the growth suppression of the normal and malignant human endometrial glandular cells. Endocrinology 142,4182-4188.
16. Signoretti S, Di Marcotullio L, Richardson A, Ramaswamy S, Isaac B, Rue M, Monti F, Loda M and Pagano M (2002) Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J Clin Invest 110, 633-641.
17. Speroff L, Glass RH and Kase NG (1994) Induction of ovulation. In Clinical Gynecologic Endocrinology and Infertility. 5th edn, Williams & Wilkins, Baltimore, pp 915-917.
18. Tan P, Cady B, Wanner M, Worland P, Cukor B, Magi-Galluzzi C, Lavin P, Draetta G, Pagano M and Loda M (1997) The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res 57,1259-1263.
19. Tong W and Pollard JW (1999) Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice. Mol Cell Biol 19,2251-2264.
20. Tsihlias J, Kapusta LR, DeBoer G, Morava-Protzner I, Zbieranowski I, Bhattacharya N, Catzavelos GC, Klotz LH and Slingerland JM (1998) Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. Cancer Res 58, 542-548.
21. Utsunomiya H, Suzuki T, Kaneko C, Takeyama J, Nakamura J, Kimura K, Yoshihama M, Harada N, Ito K, Konno R et al. (2001) The analyses of 17β-hydroxysteroid dehydrogenase isozymes in human endometrial hyperplasia and carcinoma. J Clin Endocrinol Metab 86,3436-3443.
22. Waltregny D, Leav I, Signoretti S, Soung P, Lin D, Merk F, Adams JY, Bhattacharya N, Cirenei N and Loda M (2001) Androgen-driven prostate epithelial cell proliferation and differentiation in vivo involve the regulation of p27. Mol Endocrinol 15,765-782.
23. Watanabe J, Sato H, Kanai T, Kamata Y, Jobo T, Hata H, Fujisawa T, Ohno E, Kameya T and Kuramoto H (2002) Paradoxical expression of cell cycle inhibitor p27 in endometroid adenocarcinoma of the uterine corpus - correlation with proliferation and clinicopathological parameters. Br J Cancer 87,81-85.
24. Yang G, Cai KQ, Thompson-Lanza JA, Bast RC and Liu J (2003) Inhibition of breast and ovarian tumor growth through multiple signaling pathways by using retrovirus-mediated siRNA silencing against Her-2/neu gene expression. J Biol Chem 279,4339-4345.