Up-regulation of p27Kip1 by progestins is involved in the growth suppression of the normal and malignant human endometrial glandular cells

Endocrinology

Volumn 142, Issue 10, 2001, Pages 4182-4188

  Shiozawa, T ^a   Horiuchi, A ^a   Kato, K ^a   Obinata, M ^a   Konishi, I ^a   Fujii, S ^a   Nikaido, T ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; ESTRADIOL; GESTAGEN; MESSENGER RNA; PROGESTERONE; PROTEIN P27; THYMIDINE; TRITIUM;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; ENDOMETRIUM CANCER; ENDOMETRIUM CELL; FEMALE; GROWTH INHIBITION; HORMONAL REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UTERUS CANCER;

EID: 0034802111     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.10.8455     Document Type: Article

References (41)

1. The endometrium and myometrium: Regulation and dysfunction
2. The treatment of cencer by progestogens
3. Gestagens and endometrial carcinoma
4. Endometrial carcinoma: Steroid receptors and response to medroxyprogesterone acetate
5. Steroid rceptors and response of endometrial cancer to hormones in vitro
6. Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle
7. Estradiol and progesterone receptors in human endometrium: Normal and abnormal cycles and pregnancy
8. Cyclic changes of estradiol metabolic enzymes in human endometrium during the menstrual cycle
9. Growth factors and growth modulators in human uterine endometrium: Their potential relevance to reproductive medicine
10. 1 phase progression: Cyclin on cue
11. 1 cyclin-dependent kinases
12. Ordering S phase and M phase in the cell cycle
13. Cloning of p27Kip1, a cydin- dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
14. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21
15. Mice lacking p27Kip1 display increased body size, multiorgan hyperplasia, retinal dysplasia, and pituitary tumors
16. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1
17. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27Kip1-deficient mice
18. Involvement of the cyclin-dependent kinase inhibitor p27Kip1 in the growth inhibition of endometrium in the secretory phase and in hyperplastic endometrium treated with progesterone
19. Dating the endometrial biopsy
20. A morphological study of glandular formation and epithelization from normal human endometrial epithelial cells in vitro
21. Interleukin-1 inhibits in vitro decidualization of human endometrial stromal cells
22. In vitro culture of endometrial stromal and gland cells as a model for endometriosis: The effect of peritoneal fluid on proliferation
23. Detection of p27/Kip1 mRNA in blood cells by nonradioactive ribonuclease protection assay
24. In vitro study of the effect of sex steroid and growth factor on growth and laminin, collagen IV, and tissue plasminogen activator production of normal endometrial cells and endometrial cancer cells in culture
25. Convergence of progesterone and epidermal growth factorsignaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways
26. Relationship between the expression of cyclins/cyclin-dependent kinases and sex-steroid receptors/Ki-67 in normal human endometrial glands and stroma during the menstrual cycle
27. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by Myo D
28. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells
29. 3 in HL60 cells
30. Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines
31. Localization of apoptotic cells within the human endometrium and correlation between apoptosis and p21 expression
32. In vitro growth regulation of endometrial carcinoma cells by tamoxifen and medroxyprogesterone acetate
33. Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone
34. Transforming growth factor gene expression in human endometrial adenocarcinoma cells: Regulation by Frogestins
35. Regulation of transforming growth factor gene expression in human endometrial adenocarcinoma cells
36. Role of the ubiquitinproteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
37. Translational control of p27Kip1 accumulation during the cell cycle
38. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
39. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
40. Cell cycle- dependent phosphorylation of p27 cyclin-dependent kinase (cdk) inhibitor by cyclin E/cdk2
41. Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing