Paradoxical expression of cell cycle inhibitor p27 in endometrioid adenocarcinoma of the uterine corpus - Correlation with proliferation and clinicopathological parameters

British Journal of Cancer

Volumn 87, Issue 1, 2002, Pages 81-85

  Watanabe, J ^a   Sato, H ^b   Kanai, T ^b   Kamata, Y ^b   Jobo, T ^a   Hata, H ^a   Fujisawa, T ^b   Ohno, E ^c   Kameya, T ^a   Kuramoto, H ^a,b,c  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

Cell proliferation; Clinicopathological parameter; Endometrioid adenocarcinoma; Endometrium; p27

Indexed keywords

BIOTIN; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; FORMALDEHYDE; KI 67 ANTIGEN; PARAFFIN; PROTEIN P27; STREPTAVIDIN;

ARTICLE; CANCER GRADING; CANCER INVASION; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL LABELING; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOMETRIUM CARCINOMA; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; MITOSIS INHIBITION; PRIORITY JOURNAL; PROGNOSIS; TISSUE FIXATION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CELL CYCLE PROTEINS; CELL DIVISION; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM STAGING; TUMOR SUPPRESSOR PROTEINS;

EID: 18544367664     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600434     Document Type: Article

References (26)

1. K1P in uterine endometrial carcinoma relationship with p53 status
2. K1Pl expression and progression of human esophageal squamous cell carcinoma
3. Strongly reduced expression of the cell cycle inhibitor p27 in endometrial neoplasia
4. Kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells
5. Skp2 is required for ubiquitin-mediated degradation of the Cdk inhibitor p27
6. kip1 in metastatic colorectal carcinoma
7. FIGO news
8. Kip1 and degree of malignancy in human breast and colorectal cancers
9. Kip1 expression and interaction with other cell cydin-associated proteins in mammary carcinoma
10. Molecular analysis of the cyclin-dependent kinase inhibitor P27/Kip1 in human malignancies
11. Kip1and cyclin-dependent kinase2 in the proliferation of non-small cell lung cancer
12. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
13. Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 in epithelial ovarian cancer
14. Alterations of the p27Kip1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma
15. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
16. The role of p27 in endometrial carcinoma
17. Comparison of endometrial carcinoma coexisting with and without endometrial hyperplasia
18. Kip1: Chromosomal mapping to 12p12-12p13.1 and absence of mutation in human tumors
19. kip1 cyclin-dependent kinase inhibitor bound to the cyclinA-cdk2 complex
20. Cancer cell cycles
21. kip1 in growth inhibition of endometrium in the secretory phase and of hyperplastic endometrium treated with progesterone
22. Tumor extension and cell proliferation in adenocarcinoma of the lung
23. Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma
24. Kip1 is instigated by Jab1
25. Antiestrogen inhibition of cell cycle progression in breast cancer cells is associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation
26. Kip1 protein in human prostate cancer correlates with tumor grade