CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1α

Cancer Research

Volumn 64, Issue 17, 2004, Pages 6075-6081

  Fox, Stephen B ^a   Bragança, José ^b   Turley, Helen ^a   Campo, Leticia ^a   Han, Cheng ^c   Gatter, Kevin C ^a   Bhattacharya, Shoumo ^b   Harris, Adrian L ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; FLUOROURACIL; HISTONE ACETYLTRANSFERASE PCAF; HYPOXIA INDUCIBLE FACTOR 1; METHOTREXATE; TAMOXIFEN; TRANSCRIPTION FACTIR CITED2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR CITED4; UNCLASSIFIED DRUG;

ADULT; AGE; ANGIOGENESIS; ARTICLE; AXILLARY LYMPH NODE; BREAST; BREAST CANCER; BREAST TUMOR; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER MORTALITY; CANCER RECURRENCE; CANCER SURVIVAL; CARCINOMA IN SITU; CH1 DOMAIN; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; FEMALE; GENE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPOXIA; HYPOXIA REPONSIVE GENE; IN VITRO STUDY; LYMPH NODE BIOPSY; MAJOR CLINICAL STUDY; MASTECTOMY; NUCLEAR LOCALIZATION SIGNAL; PARTIAL MASTECTOMY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BREAST NEOPLASMS; CELL HYPOXIA; CYTOPLASM; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 4344594531     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0708     Document Type: Article

References (31)

1. Bhattacharya S, Michels CL, Leung MK, et al. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev 1999;13:64-75.
2. Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S. Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrgl. Genomics 1999;61:307-13.
3. Freedman SJ, Sun ZY, Kung AL, et al. Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol 2003;10:504-12.
4. Bhattacharya S, Ratcliffe PJ. ExCITED about HIF. Nat Struct Biol 2003;10:501-3.
5. Yin Z, Haynie J, Yang X, et al. The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci USA 2002;99:10488-93.
6. Bamforth SD, Braganca J, Eloranta JJ, et al. Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 coactivator. Nat Genet 2001;29:469-74.
7. Braganca J, Eloranta JJ, Bamforth SD, et al. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J Biol Chem 2003;278:16021-9.
8. Barbera JP, Rodriguez TA, Greene ND, et al. Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet 2002;11:283-93.
9. Kranc KR, Bamforth SD, Braganca J, et al. Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Mol Cell Biol 2003;23:7658-66.
10. Braganca J, Swingler T, Marques FI, et al. Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. J Biol Chem 2002;277:8559-65.
11. Yahata T, Takedatsu H, Dunwoodie SL, et al. Cloning of mouse cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells. Genomics 2002;80:601-13.
12. Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000;157:411-21.
13. Eckner R, Ludlow JW, Lill NL, et al. Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol 1996;16:3454-64.
14. Bhattacharya S, Eckner R, Grossman S, et al. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (Lond) 1996;383:344-7.
15. Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997;11:72-82.
16. Ausubel F, Brent R, Kingston R, et al. Short protocols in molecular biology. 3rd ed. Hoboken, NJ: John Wiley and Sons, Inc.; 1995.
17. Turley H, Scott PA, Watts VM, et al. Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1. J Pathol 1998;186:313-8.
18. White JD, Hewett PW, Kosuge D, et al. Vascular endothelial growth factor-D expression is an independent prognostic marker for survival in colorectal carcinoma. Cancer Res 2002;62:1669-75.
19. Fox SB, Leek RD, Weekes MP, et al. Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol 1995;177:275-83.
20. Li H, Ahmed NU, Fenner MH, et al. Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells. Exp Cell Res 1998;242:478-86.
21. Blagosklonny MV. Are p27 and p21 cytoplasmic oncoproteins? Cell Cycle 2002;1:391-3.
22. Harris AL. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.
23. Wiechens N, Fagotto F. CRM1- and Ran-independent nuclear export of beta-catenin. Curr Biol 2001;11:18-27.
24. Lu W, Pochampally R, Chen L, et al. Nuclear exclusion of p53 in a subset of tumors requires MDM2 function. Oncogene 2000;19:232-40.
25. Winters ZE, Hunt NC, Bradburn MJ, et al. Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer, association with prognosis. Eur J Cancer 2001;37:2405-12.
26. Bos R, van der Groep P, Greijer AE, et al. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer (Phila) 2003:97:1573-81.
27. Brenneisen P, Blaudschun R, Gille J, et al. Essential role of an activator protein-2 (AP-2)/specificity protein 1 (Sp1) cluster in the UVB-mediated induction of the human vascular endothelial growth factor in HaCaT keratinocytes. Biochem J 2003;369:341-9.
28. Jubb AM, Pham TQ, Hanby AM, et al. Expression of vascular endothelial growth factor, hypoxia inducible factor 1α and carbonic anhydrase IX in human tumours. J Clin Pathol 2004;57:504-12.
29. Hilger-Eversheim K, Moser M, Schorle H, Buettner R. Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control. Gene (Amst) 2000;260:1-12.
30. Pellikainen J, Kataja V, Ropponen K, et al. Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer. Clin Cancer Res 2002;8:3487-95.
31. Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM. CBP/p300 interact with and function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci USA 2000;97:1020-5.