Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control

Gene

Volumn 260, Issue 1-2, 2000, Pages 1-12

  Hilger Eversheim, Kristina ^a   Moser, Markus ^a   Schorle, Hubert ^b   Buettner, Reinhard ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

AP 2 knock out mice; Apoptosis; c erbB 2; c myc; Char syndrome; p21

Indexed keywords

DNA BINDING PROTEIN; TRANSCRIPTION FACTOR AP 2;

APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH; CHAR SYNDROME; CONGENITAL MALFORMATION; EVOLUTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; MALFORMATION SYNDROME; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; HUMANS; MUTATION; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; VERTEBRATES;

VERTEBRATA;

EID: 0034736585     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00454-6     Document Type: Review

References (71)

1. RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2
2. The genomic structure of the human AP-2 transcription factor
3. Cloning and characterization of the Drosophila homologue of the AP-2 transcription factor
4. The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma
5. A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma
6. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
7. An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2
8. Programming gene expression in developing epidermis
9. AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis
10. Regulation of K3 Keratin gene transcription by Sp1 and AP-2 in differentiating rabbit corneal epithelial cells
11. Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells
12. Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression
13. The MYC protein activates transcription of the alpha-prothymosin gene
14. Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues
15. Analysis of cranial neural crest migratory pathways in axolotl using cell markers and transplantation
16. Induction of apoptosis in fibroblasts by c-myc protein
17. Positive and negative transcriptional elements of the human type IV collagenase gene
18. Transcriptional activation by Myc is under negative control by transcription factor AP-2
19. Localization of the gene for the DNA-binding protein AP-2 to human chromosome 6p22.3-pter
20. Immunohistological analysis reveals a tumor suppressor-like role for the transcription factor AP-2 in invasive breast cancer
21. Transcription factor AP-2 regulates expression of the dopamine beta-hydroxylase gene
22. A new cis element is involved in the HER2 gene overexpression in human breast cancer cells
23. Targeting gene transcription: A new strategy to down-regulate c-erbB-2 expression in mammary carcinoma
24. Loss of Ap-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis
25. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP
26. Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells
27. Depression of the C/EBPa gene during adipogenesis: Identification of AP-2α as a repressor
28. N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation
29. Transcription factor AP2 and its role in epidermal-specific gene expression
30. Requirement for neuregulin receptor erbB2 in neural and cardiac development
31. Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000
32. Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers
33. Identification of ERF-1 as a member of the AP2 transcription factor family
34. Cell-cell signalling. Neu tack on neuregulin
35. Keratin 10 gene expresssion during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2
36. Induction of WAF1/CIP1 by a p53-independent pathway
37. Identification of the elements regulating the expression of thecell adhesion molecule MCAM/MUC18: Loss of AP-2 is not required for MCAM expression in melanoma cell lines
38. Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis
39. Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen
40. SELEX and missing phosphate contact analyses reveal flexibility within the AP-2[alpha] protein: DNA binding complex
41. DAP-2, the Drosophila homolog of transcription factor AP-2
42. Cloning and characterization of a second AP-2 transcription factor: AP-2β
43. Comperative Analysis of AP-2α and AP-2β gene expression during murine embryogenesis
44. Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2β
45. Regulation of HTLV-I gene expression by tax and AP-2
46. Transcription factor AP-2 activates gene expression of HTLV-I
47. Fine mapping of the autosomal recessive polycystic kidney disease locus (PKHD1) and the genes MUT, RDS, CSNK2 beta, and GSTA1 at 6p21.1-p12
48. AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice
49. A novel alternative spliced variant of the transcription factor AP2alpha is expressed in the murine ocular lens
50. AP-2.2: A novel AP-2-related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells
51. Transcription factor AP-2 regulates human immunodeficiency virus type 1 gene expression
52. Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation
53. Char syndrome, an inherited disorder with patent ductus arteriosus, maps to chromosome 6p12-p21
54. Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus
55. Transcription factor AP-2 essential for cranial closure and craniofacial development
56. A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor receptor gene and is amplified in a human salivary gland adenocarcinoma
57. Chicken transcription factor AP-2: Cloning, expression and its role in outgrowth of facial prominences and limb buds
58. Neurulation: Coming to closure
59. Transcription factor AP-2 is tissue-specific in Xenopus and is closely related or identical to keratin transcription factor 1 (KTF-1)
60. Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice
61. C-myc as an inducer of polycystic kidney disease in transgenic mice
62. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways
63. Transcription factor AP-2 controls transcription of the human transforming growth factor-alpha gene
64. Characterization of the activation domains of AP-2 family transcription factors
65. AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle
66. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2
67. Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins
68. Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription
69. WAF1/CIP1 expression
70. Mapping of the gene for autosomal recessive polycystic kidney disease (ARPKD) to chromosome 6p21-cen
71. Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2