Allelic variation in class I K gene as candidate for a second component of MHC-linked susceptibility to Type 1 diabetes in non-obese diabetic mice

Diabetologia

Volumn 47, Issue 4, 2004, Pages 739-747

  Inoue, K ^a   Ikegami, H ^a   Fujisawa, T ^a   Noso, S ^a   Nojima, K ^a   Babaya, N ^a   Itoi Babaya, M ^a   Makino, S ^a   Ogihara, T ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Congenic mouse; CTS mouse; Gene; H2 K Idd16; Major histocompatibility complex; Monoclonal antibody; Non obese diabetic mouse; Sequence; Type 1 diabetes

Indexed keywords

MONOCLONAL ANTIBODY;

ALLELE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGENIC STRAIN; CONTROLLED STUDY; DIABETIC OBESITY; DISEASE PREDISPOSITION; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENETIC PREDISPOSITION; GENETIC RESISTANCE; GENETIC VARIABILITY; HISTOCOMPATIBILITY GENE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS 1 K GENE; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRAIN DIFFERENCE;

ALLELES; ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; DIABETES MELLITUS, TYPE 1; DNA; EXONS; GENES, MHC CLASS I; INTRONS; LYMPHOCYTES; MICE; MICE, CONGENIC; MICE, INBRED NOD; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; VARIATION (GENETICS);

EID: 2442650465     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1370-2     Document Type: Article

References (47)

1. Castano L, Eisenbarth GS (1990) Type 1 diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol 8:647-679
2. Davies JL, Kawaguchi Y, Bennett ST et al. (1994) A genome-wide search for human type 1 diabetes susceptibility genes. Nature 8:130-136
3. Wicker LS, Todd JA, Perterson LB (1995) Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol 13:179-200
4. Ikegami H, Ogihara T (1996) Genetics of insulin-dependent diabetes mellitus. Endocr J 43:605-613
5. Fujisawa T, Ikegami H, Kawaguchi Y et al. (1995) Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM. Diabetologia 38:1493-1495
6. Park B, Lee S, Kim E et al. (2003) A single polymorphic residue within the peptide-binding cleft of MHC class I molecules determines spectrum of tapsin dependence. J Immunol 170:961-968
7. Kawabata Y, Ikegami H, Kawaguchi Y et al. (2000) Age-related association of MHC class I chain-related gene A (MICA) with type 1 (insulin-dependent) diabetes mellitus. Hum Immunol 611:624-629
8. Nakanishi K, Kobayashi T, Murase T et al. (1993) Association of HLA-A24 with complete beta-cell destruction in IDDM. Diabetes 42:1086-1093
9. Nesentsev S, Gombos Z, Laine AP et al. (2000) Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B. Diabetes 49:2217-2221
10. Johansson S, Lie BA, Todd JA et al. (2003) Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1. Genes Immun 4:46-53.
11. Valdes AM, Thomson G, Erlich HA, Noble JA (1999) Association between type 1 diabetes age of onset and HLA among sibling pairs. Diabetes 48:1658-1661
12. Hodgkinson AD, Millward BA, Demaine AG (2000) HLA-E locus is associated with age at onset and susceptibility to type 1 diabetes mellitus. Hum Immunol 61:290-295
13. Hattori M, Buse JB, Jackson RA et al. (1986) The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 14:733-735
14. Prochazka M, Leiter EH, Serreze DV et al. (1987) Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science 237:286-289
15. Wicker LS, Miller BJ, Coker LZ et al. (1987) Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J Exp Med 165:1639-1654
16. Wicker LS, Appel MC, Dotta F et al. (1992) Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J Exp Med 176:67-77
17. Prochazka M, Serreze DV, Worthen SM et al. (1989) Genetic control of diabetogenesis in NOD/Lt mice. Diabetes 38:1446-1455
18. Ikegami H, Eisenbarth GS, Hattori M (1999) Major histocompatibility complex-linked diabetogenic gene of the nonobese diabetic mouse. J Clin Invest 85:18-24
19. Ikegami H, Makino S, Yamato E et al. (1995) Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping. J Clin Invest 96:1936-1942
20. Babaya N, Ikegami H, Kawagichi Y et al. (2000) Congenic mapping and functional analysis of a second component of the MHC-linked diabetogenic gene (Idd16). Int J Diabetes 8:1-7
21. Ikegami H, Makino S, Harada M et al. (1988) The cataract Shionogi mouse, a sister strain of the non-obese diabetic mouse: similar class II but different at class I gene products. Diabetologia 31:254-258
22. Hattoti M, Yamato E, Itoh N et al. (1999) Homologous recombination of the MHC class I K region defines new MHC-linked diabetogenic susceptibility genes in nonobese diabetic mice. J Immunol 163:1721-1724
23. d is diabetogenic in the NOD mouse. Diabetes 52 [Suppl 1]:A248 (Abstract)
24. b gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibility antigens. EMBO J 2:453-452
25. b promoter: enhancer-like sequences and their role in the regulation of class I gene expression. Cell 44:261-272
26. d gene. EMBO J 2:245-254
27. k gene. Comparison of three H-2K locus alleles. Nucleic Acids Res 12:9473-9487
28. g7K and D loci of nonobese diabetic mice. Immunogenetics 41:386
29. Mathews CE, Graser RT, Serreze DV et al. (2000) Re-evaluation of the major histocompatibility complex genes of the NOD-progenitor CTS/Shi strain. Diabetes 49:131-134
30. Wicker LS, Leiter EH, Todd JA et al. (1994) Beta 2-microglobulin- deficient NOD mice do not develop insulitis or diabetes. Diabetes 43:500-504
31. nul mice are diabetes and insulitis resistant. Diabetes 43:505-509
32. Sumida T, Furukawa M, Sakamoto A et al. (1994) Prevention of insulitis and diabetes in β2-microglobulin-deficient non-obese diabetic mice. Int Immunol 6:1445-1449
33. Perarnau B, Siegrist CA, Gillet A et al. (1990) β2-microglobulin restriction of antigen presentation. Nature 346:751-754
34. Katz J, Benoist C, Mathis D (1993) Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic nice. Eur J Immunol 23:3358-3360
35. Anderson B, Park B, Verdaguer J et al. (1998) Prevalent CD8+ T cell response against one peptide/MHC complex in autoimmune diabetes. Proc Natl Acad Sci USA 96:9311-9316
36. Dilorenzo TP, Graser RT, Ono T et al. (1998) Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor a chain gene rearrangement. Proc Natl Acad Sci USA 95:12538-12543
37. Santamaria P, Utsugi T, Park BJ et al. (1995) Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor α-chain CDR3 sequences. J Immunol 154:2494-2503
38. Wong FS, Visintin I, Wen L et al. (1996) CD8 T cell clones from young nonobese diabetic mice (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J Exp Med 183:67-76
39. d monoclonal antibody. Diabetes 40:1203-1209
40. Boulard O, Damotte D, Deruytter N et al. (2002) An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice. Diabetes 51:2141-2147
41. Babaya N, Ikegami H, Fujisawa T et al. (2002) Sequence analysis of Tnf as a candidate gene for Idd16. Autoimmunity 35:63-66
42. Robles DT, Eisenbarth GS, Wang T et al. (2002) Identification of children with early onset and high incidence of anti-islet autoantibodies. Clin Immunol 102:217-224
43. Gupta M, Nikitina-Zake L, Zarghami M et al. (2003) Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden. Hum Immunol 64:553-561
44. Fennessy M, Metcalfe K, Hitman GA et al. (1994) A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group. Diabetologia 37:937-944
45. Todd JA, Bell JI, McDevitt HO (1987) HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329:599-604
46. Lund T, O'Reilly L, Hutchings P et al. (1990) Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain. Nature 345:727-729
47. Perarnau B, Siegrist CA, Gillet A et al. (1990) β2-microglobulin restriction of antigen presentation. Nature 346:751-754