-
1
-
-
3242781731
-
Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
-
Hofbauer LC, Schoppet M (2004) Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. Jama 292:490-495
-
(2004)
Jama
, vol.292
, pp. 490-495
-
-
Hofbauer, L.C.1
Schoppet, M.2
-
2
-
-
0030749321
-
Skeletal complications of malignancy
-
Coleman RE (1997) Skeletal complications of malignancy. Cancer 80:1588-1594
-
(1997)
Cancer
, vol.80
, pp. 1588-1594
-
-
Coleman, R.E.1
-
3
-
-
30944436527
-
Mechanisms of disease: Roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis
-
Blair JM, Zhou H, Seibel MJ et al (2006) Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nat Clin Pract Oncol 3:41-49
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 41-49
-
-
Blair, J.M.1
Zhou, H.2
Seibel, M.J.3
-
4
-
-
0034284970
-
Bone resorption by osteoclasts
-
Teitelbaum SL (2000) Bone resorption by osteoclasts. Science 289:1504-1508
-
(2000)
Science
, vol.289
, pp. 1504-1508
-
-
Teitelbaum, S.L.1
-
5
-
-
0037673945
-
Osteoclast differentiation and activation
-
Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature 423:337-342
-
(2003)
Nature
, vol.423
, pp. 337-342
-
-
Boyle, W.J.1
Simonet, W.S.2
Lacey, D.L.3
-
6
-
-
0033304730
-
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
-
Suda T, Takahashi N, Udagawa N et al (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20:345-357
-
(1999)
Endocr Rev
, vol.20
, pp. 345-357
-
-
Suda, T.1
Takahashi, N.2
Udagawa, N.3
-
7
-
-
0041304833
-
Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics
-
Zaidi M, Blair HC, Moonga BS et al (2003) Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics. J Bone Miner Res 18:599-609
-
(2003)
J Bone Miner Res
, vol.18
, pp. 599-609
-
-
Zaidi, M.1
Blair, H.C.2
Moonga, B.S.3
-
8
-
-
0032494113
-
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts
-
Fuller K, Wong B, Fox S et al (1998) TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J Exp Med 188:997-1001
-
(1998)
J Exp Med
, vol.188
, pp. 997-1001
-
-
Fuller, K.1
Wong, B.2
Fox, S.3
-
9
-
-
0037398261
-
Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
-
Eghbali-Fatourechi G, Khosla S, Sanyal A et al (2003) Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest 111:1221-1230
-
(2003)
J Clin Invest
, vol.111
, pp. 1221-1230
-
-
Eghbali-Fatourechi, G.1
Khosla, S.2
Sanyal, A.3
-
10
-
-
0030714605
-
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
-
Anderson DM, Maraskovsky E, Billingsley WL et al (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175-179
-
(1997)
Nature
, vol.390
, pp. 175-179
-
-
Anderson, D.M.1
Maraskovsky, E.2
Billingsley, W.L.3
-
11
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
Lacey DL, Timms E, Tan HL et al (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176
-
(1998)
Cell
, vol.93
, pp. 165-176
-
-
Lacey, D.L.1
Timms, E.2
Tan, H.L.3
-
12
-
-
0032584208
-
Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
-
Yasuda H, Shima N, Nakagawa N et al (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95:3597-3602
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3597-3602
-
-
Yasuda, H.1
Shima, N.2
Nakagawa, N.3
-
13
-
-
0031005576
-
Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
-
Simonet WS, Lacey DL, Dunstan CR et al (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309-319
-
(1997)
Cell
, vol.89
, pp. 309-319
-
-
Simonet, W.S.1
Lacey, D.L.2
Dunstan, C.R.3
-
14
-
-
0030989969
-
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
-
Tsuda E, Goto M, Mochizuki S et al (1997) Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 234:137-142
-
(1997)
Biochem Biophys Res Commun
, vol.234
, pp. 137-142
-
-
Tsuda, E.1
Goto, M.2
Mochizuki, S.3
-
15
-
-
0033591005
-
Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation
-
Nagai M, Sato N (1999) Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation. Biochem Biophys Res Commun 257:719-723
-
(1999)
Biochem Biophys Res Commun
, vol.257
, pp. 719-723
-
-
Nagai, M.1
Sato, N.2
-
16
-
-
0034996687
-
The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis
-
Fazzalari NL, Kuliwaba JS, Atkins GJ et al (2001) The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis. J Bone Miner Res 16:1015-1027
-
(2001)
J Bone Miner Res
, vol.16
, pp. 1015-1027
-
-
Fazzalari, N.L.1
Kuliwaba, J.S.2
Atkins, G.J.3
-
17
-
-
0142182080
-
Receptor activator of nuclear factor kappaB ligand (RANKL)/ osteoprotegerin (OPG) ratio is increased in severe osteolysis
-
Grimaud E, Soubigou L, Couillaud S et al (2003) Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis. Am J Pathol 163:2021-2031
-
(2003)
Am J Pathol
, vol.163
, pp. 2021-2031
-
-
Grimaud, E.1
Soubigou, L.2
Couillaud, S.3
-
18
-
-
0034930640
-
Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint
-
Haynes DR, Crotti TN, Loric M et al (2001) Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint. Rheumatology (Oxford) 40:623-630
-
(2001)
Rheumatology (Oxford)
, vol.40
, pp. 623-630
-
-
Haynes, D.R.1
Crotti, T.N.2
Loric, M.3
-
19
-
-
0033581952
-
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
-
Kong YY, Feige U, Sarosi I et al (1999) Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402:304-309
-
(1999)
Nature
, vol.402
, pp. 304-309
-
-
Kong, Y.Y.1
Feige, U.2
Sarosi, I.3
-
20
-
-
24644434101
-
RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis
-
Stolina M, Adamu S, Ominsky M et al (2005) RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis. J Bone Miner Res 20:1756-1765
-
(2005)
J Bone Miner Res
, vol.20
, pp. 1756-1765
-
-
Stolina, M.1
Adamu, S.2
Ominsky, M.3
-
21
-
-
0035895083
-
Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
-
Giuliani N, Bataille R, Mancini C et al (2001) Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 98:3527-3533
-
(2001)
Blood
, vol.98
, pp. 3527-3533
-
-
Giuliani, N.1
Bataille, R.2
Mancini, C.3
-
22
-
-
0037108435
-
Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells
-
Standal T, Seidel C, Hjertner O et al (2002) Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells. Blood 100:3002-3007
-
(2002)
Blood
, vol.100
, pp. 3002-3007
-
-
Standal, T.1
Seidel, C.2
Hjertner, O.3
-
23
-
-
0035866399
-
Receptor activator of nuclear factor kappaB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly developed model of human neuroblastoma
-
Michigami T, Ihara-Watanabe M, Yamazaki M et al (2001) Receptor activator of nuclear factor kappaB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly developed model of human neuroblastoma. Cancer Res 61:1637-1644
-
(2001)
Cancer Res
, vol.61
, pp. 1637-1644
-
-
Michigami, T.1
Ihara-Watanabe, M.2
Yamazaki, M.3
-
24
-
-
0036675220
-
Metastasis to bone: Causes, consequences and therapeutic opportunities
-
Mundy GR (2002) Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2:584-593
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 584-593
-
-
Mundy, G.R.1
-
25
-
-
0026352946
-
Osteoclast resorption-stimulating activity is associated with the osteoblast cell surface and/or the extracellular matrix
-
Fuller K, Gallagher AC, Chambers TJ (1991) Osteoclast resorption-stimulating activity is associated with the osteoblast cell surface and/or the extracellular matrix. Biochem Biophys Res Commun 181:67-73
-
(1991)
Biochem Biophys Res Commun
, vol.181
, pp. 67-73
-
-
Fuller, K.1
Gallagher, A.C.2
Chambers, T.J.3
-
26
-
-
0035054126
-
Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus
-
Ikeda T, Kasai M, Utsuyama M et al (2001) Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus. Endocrinology 142:1419-1426
-
(2001)
Endocrinology
, vol.142
, pp. 1419-1426
-
-
Ikeda, T.1
Kasai, M.2
Utsuyama, M.3
-
27
-
-
0942268164
-
Regulation of osteoclastogenesis by three human RANKL isoforms expressed in NIH3T3 cells
-
Suzuki J, Ikeda T, Kuroyama H et al (2004) Regulation of osteoclastogenesis by three human RANKL isoforms expressed in NIH3T3 cells. Biochem Biophys Res Commun 314:1021-1027
-
(2004)
Biochem Biophys Res Commun
, vol.314
, pp. 1021-1027
-
-
Suzuki, J.1
Ikeda, T.2
Kuroyama, H.3
-
28
-
-
15044348241
-
Increased bone resorption in HD patients: Is it caused by elevated RANKL synthesis?
-
Avbersek-Luznik I, Balon BP, Rus I et al (2005) Increased bone resorption in HD patients: is it caused by elevated RANKL synthesis? Nephrol Dial Transplant 20:566-570
-
(2005)
Nephrol Dial Transplant
, vol.20
, pp. 566-570
-
-
Avbersek-Luznik, I.1
Balon, B.P.2
Rus, I.3
-
29
-
-
33745030280
-
The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destruction
-
Geusens PP, Landewe RB, Garnero P et al (2006) The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destruction. Arthritis Rheum 54:1772-1777
-
(2006)
Arthritis Rheum
, vol.54
, pp. 1772-1777
-
-
Geusens, P.P.1
Landewe, R.B.2
Garnero, P.3
-
30
-
-
3242795997
-
Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: New pieces of the puzzle
-
Morabito N, Gaudio A, Lasco A et al (2004) Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: new pieces of the puzzle. J Bone Miner Res 19:722-727
-
(2004)
J Bone Miner Res
, vol.19
, pp. 722-727
-
-
Morabito, N.1
Gaudio, A.2
Lasco, A.3
-
31
-
-
18044394042
-
Circulating amounts of osteoprotegerin and RANK ligand: Genetic influence and relationship with BMD assessed in female twins
-
Abrahamsen B, Hjelmborg JV, Kostenuik P et al (2005) Circulating amounts of osteoprotegerin and RANK ligand: genetic influence and relationship with BMD assessed in female twins. Bone 36:727-735
-
(2005)
Bone
, vol.36
, pp. 727-735
-
-
Abrahamsen, B.1
Hjelmborg, J.V.2
Kostenuik, P.3
-
32
-
-
0034698926
-
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis
-
Min H, Morony S, Sarosi I et al (2000) Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis. J Exp Med 192:463-474
-
(2000)
J Exp Med
, vol.192
, pp. 463-474
-
-
Min, H.1
Morony, S.2
Sarosi, I.3
-
33
-
-
0027703826
-
Effects of rehydration state on the flexural properties of whole mouse long bones
-
Broz JJ, Simske SJ, Greenberg AR et al (1993) Effects of rehydration state on the flexural properties of whole mouse long bones. J Biomech Eng 115:447-449
-
(1993)
J Biomech Eng
, vol.115
, pp. 447-449
-
-
Broz, J.J.1
Simske, S.J.2
Greenberg, A.R.3
-
34
-
-
0034915025
-
The effects of osteoprotegerin on the mechanical properties of rat bone
-
Ross AB, Bateman TA, Kostenuik PJ et al (2001) The effects of osteoprotegerin on the mechanical properties of rat bone. J Mater Sci Mater Med 12:583-588
-
(2001)
J Mater Sci Mater Med
, vol.12
, pp. 583-588
-
-
Ross, A.B.1
Bateman, T.A.2
Kostenuik, P.J.3
-
35
-
-
0023488581
-
Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
-
Parfitt AM, Drezner MK, Glorieux FH et al (1987) Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610
-
(1987)
J Bone Miner Res
, vol.2
, pp. 595-610
-
-
Parfitt, A.M.1
Drezner, M.K.2
Glorieux, F.H.3
-
36
-
-
0141523159
-
Osteoprotegerin levels in primary hyperparathyroidism: Effect of parathyroidectomy and association with bone metabolism.
-
Stilgren LS, Hegedus LM, Beck-Nielsen H et al (2003) Osteoprotegerin levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism. Calcif Tissue Int 73:210-216
-
(2003)
Calcif Tissue Int
, vol.73
, pp. 210-216
-
-
Stilgren, L.S.1
Hegedus, L.M.2
Beck-Nielsen, H.3
-
37
-
-
2942715123
-
Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-kappab ligand mRNA levels in primary hyperparathyroidism: Effect of parathyroidectomy and association with bone metabolism
-
Stilgren LS, Rettmer E, Eriksen EF et al (2004) Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-kappab ligand mRNA levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism. Bone 35:256-265
-
(2004)
Bone
, vol.35
, pp. 256-265
-
-
Stilgren, L.S.1
Rettmer, E.2
Eriksen, E.F.3
-
38
-
-
0141527583
-
Is the paradigm shifting?
-
Heaney RP (2003) Is the paradigm shifting? Bone 33:457-465
-
(2003)
Bone
, vol.33
, pp. 457-465
-
-
Heaney, R.P.1
-
39
-
-
0036128709
-
Biomechanics of bone: Determinants of skeletal fragility and bone quality
-
Turner CH (2002) Biomechanics of bone: determinants of skeletal fragility and bone quality. Osteoporos Int 13:97-104
-
(2002)
Osteoporos Int
, vol.13
, pp. 97-104
-
-
Turner, C.H.1
-
40
-
-
0032079445
-
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
-
Bucay N, Sarosi I, Dunstan CR et al (1998) osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12:1260-1268
-
(1998)
Genes Dev
, vol.12
, pp. 1260-1268
-
-
Bucay, N.1
Sarosi, I.2
Dunstan, C.R.3
-
41
-
-
18444365892
-
Increased RANKL/OPG mRNA ratio in iliac bone biopsies from women with hip fractures
-
Abdallah BM, Stilgren LS, Nissen N et al (2005) Increased RANKL/OPG mRNA ratio in iliac bone biopsies from women with hip fractures. Calcif Tissue Int 76:90-97
-
(2005)
Calcif Tissue Int
, vol.76
, pp. 90-97
-
-
Abdallah, B.M.1
Stilgren, L.S.2
Nissen, N.3
-
42
-
-
34347376250
-
Denosumab improves the structural geometry of the proximal femur in postmenopausal women with low bone mass
-
Beck TJ, Miller PD, Lewiecki EM (2006) Denosumab improves the structural geometry of the proximal femur in postmenopausal women with low bone mass. J Bone Min Res 21:S71 (Abstract)
-
(2006)
J Bone Min Res
, vol.21
, pp. 71
-
-
Beck, T.J.1
Miller, P.D.2
Lewiecki, E.M.3
-
43
-
-
33344469853
-
Denosumab in postmenopausal women with low bone mineral density
-
McClung MR, Lewiecki EM, Cohen SB et al (2006) Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 354:821-831
-
(2006)
N Engl J Med
, vol.354
, pp. 821-831
-
-
McClung, M.R.1
Lewiecki, E.M.2
Cohen, S.B.3
-
44
-
-
33644760436
-
A study of the biological receptor activator of nuclear factor-{kappa}B ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
-
Body JJ, Facon T, Coleman RE et al (2006) A study of the biological receptor activator of nuclear factor-{kappa}B ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res 12:1221-1228
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1221-1228
-
-
Body, J.J.1
Facon, T.2
Coleman, R.E.3
|