Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis

Journal of Experimental Medicine

Volumn 192, Issue 4, 2000, Pages 463-474

  Min, Hosung ^a   Morony, Sean ^a   Sarosi, Ildiko ^a   Dunstan, Colin R ^a   Capparelli, Casey ^a   Scully, Sheila ^a   Van, Gwyneth ^a   Kaufman, Steve ^a   Kostenuik, Paul J ^a   Lacey, David L ^a   Boyle, William J ^a   Simonet, W Scott ^a  

^a AMGEN INC   (United States)

Author keywords

Atherosclerosis; Osteoporosis; Osteoprotegerin; Pathologic calcification; Vascular disease

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; OSTEOPROTEGERIN; RECOMBINANT PROTEIN; REGULATOR PROTEIN;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTERY CALCIFICATION; ARTICLE; BONE; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM; GENE OVEREXPRESSION; KNOCKOUT MOUSE; MOUSE; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOPOROSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ACID PHOSPHATASE; ANIMALS; AORTA; BLOTTING, WESTERN; BONE DENSITY; CALCINOSIS; CATHEPSINS; CHO CELLS; CRICETINAE; FEMUR; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ISOENZYMES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NF-KAPPA B; OSTEOCLASTS; OSTEOPETROSIS; OSTEOPOROSIS; OSTEOPROTEGERIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT FUSION PROTEINS;

EID: 0034698926     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.4.463     Document Type: Article

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