메뉴 건너뛰기




Volumn 71, Issue 2, 2008, Pages 526-532

Hippocampal Neuron Number Is Unchanged 1 Year After Fractionated Whole-Brain Irradiation at Middle Age

Author keywords

Fischer 344 X Brown Norway rats; Fractionated WBI; Hippocampus; Middle age; Neuron number

Indexed keywords

ANIMALS; ANTIBODIES; BRAIN; IRRADIATION; RADIOTHERAPY; TISSUE ENGINEERING; TUMORS;

EID: 43049170022     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.02.015     Document Type: Article
Times cited : (39)

References (64)
  • 1
    • 33845364795 scopus 로고    scopus 로고
    • Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus
    • Shi L., Adams M.M., Long A., et al. Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiat Res 166 (2006) 892-899
    • (2006) Radiat Res , vol.166 , pp. 892-899
    • Shi, L.1    Adams, M.M.2    Long, A.3
  • 2
    • 1042301338 scopus 로고    scopus 로고
    • State-of-the-art treatment of high-grade brain tumors
    • Brandes A.A. State-of-the-art treatment of high-grade brain tumors. Semin Oncol 30 (2003) 4-9
    • (2003) Semin Oncol , vol.30 , pp. 4-9
    • Brandes, A.A.1
  • 3
    • 0036405461 scopus 로고    scopus 로고
    • Management of brain metastases
    • Soffietti R., Ruda R., and Mutani R. Management of brain metastases. J Neurol 249 (2002) 1357-1369
    • (2002) J Neurol , vol.249 , pp. 1357-1369
    • Soffietti, R.1    Ruda, R.2    Mutani, R.3
  • 4
    • 9244246263 scopus 로고    scopus 로고
    • Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI workshop, December 3-4, 2003
    • Stone H.B., Moulder J.E., Coleman C.N., et al. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI workshop, December 3-4, 2003. Radiat Res 162 (2004) 711-728
    • (2004) Radiat Res , vol.162 , pp. 711-728
    • Stone, H.B.1    Moulder, J.E.2    Coleman, C.N.3
  • 6
    • 0024785383 scopus 로고
    • Survival and quality of life after interstitial implantation of removable high-activity iodine-125 sources for the treatment of patients with recurrent malignant gliomas
    • Leibel S.A., Gutin P.H., Wara W.M., et al. Survival and quality of life after interstitial implantation of removable high-activity iodine-125 sources for the treatment of patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys 17 (1989) 1129-1139
    • (1989) Int J Radiat Oncol Biol Phys , vol.17 , pp. 1129-1139
    • Leibel, S.A.1    Gutin, P.H.2    Wara, W.M.3
  • 7
    • 0025668599 scopus 로고
    • Effects of treatment on long-term survivors with malignant astrocytomas
    • Imperato J.P., Paleologos N.A., and Vick N.A. Effects of treatment on long-term survivors with malignant astrocytomas. Ann Neurol 28 (1990) 818-822
    • (1990) Ann Neurol , vol.28 , pp. 818-822
    • Imperato, J.P.1    Paleologos, N.A.2    Vick, N.A.3
  • 8
    • 0028356814 scopus 로고
    • Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy
    • Crossen J.R., Garwood D., Glatstein E., et al. Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy. J Clin Oncol 12 (1994) 627-642
    • (1994) J Clin Oncol , vol.12 , pp. 627-642
    • Crossen, J.R.1    Garwood, D.2    Glatstein, E.3
  • 9
    • 0344441229 scopus 로고    scopus 로고
    • Radiological and clinical assessment of long-term brain tumour survivors after radiotherapy
    • Johannesen T.B., Lien H.H., Hole K.H., et al. Radiological and clinical assessment of long-term brain tumour survivors after radiotherapy. Radiother Oncol 69 (2003) 169-176
    • (2003) Radiother Oncol , vol.69 , pp. 169-176
    • Johannesen, T.B.1    Lien, H.H.2    Hole, K.H.3
  • 10
    • 0034004552 scopus 로고    scopus 로고
    • Radiotherapeutic effects on brain function: Double dissociation of memory systems
    • Armstrong C.L., Corn B.W., Ruffer J.E., et al. Radiotherapeutic effects on brain function: Double dissociation of memory systems. Neuropsychiatry Neuropsychol Behav Neurol 13 (2000) 101-111
    • (2000) Neuropsychiatry Neuropsychol Behav Neurol , vol.13 , pp. 101-111
    • Armstrong, C.L.1    Corn, B.W.2    Ruffer, J.E.3
  • 11
    • 0037046971 scopus 로고    scopus 로고
    • Late cognitive and radiographic changes related to radiotherapy: Initial prospective findings
    • Armstrong C.L., Hunter J.V., Ledakis G.E., et al. Late cognitive and radiographic changes related to radiotherapy: Initial prospective findings. Neurology 59 (2002) 40-48
    • (2002) Neurology , vol.59 , pp. 40-48
    • Armstrong, C.L.1    Hunter, J.V.2    Ledakis, G.E.3
  • 12
    • 0028914873 scopus 로고
    • Neuropsychological effects of cranial radiation: Current knowledge and future directions
    • Roman D.D., and Sperduto P.W. Neuropsychological effects of cranial radiation: Current knowledge and future directions. Int J Radiat Oncol Biol Phys 31 (1995) 983-998
    • (1995) Int J Radiat Oncol Biol Phys , vol.31 , pp. 983-998
    • Roman, D.D.1    Sperduto, P.W.2
  • 13
    • 10344263377 scopus 로고    scopus 로고
    • Pathogenesis of irradiation-induced cognitive dysfunction
    • Abayomi O.K. Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol 35 (1996) 659-663
    • (1996) Acta Oncol , vol.35 , pp. 659-663
    • Abayomi, O.K.1
  • 14
    • 33645456265 scopus 로고    scopus 로고
    • Phase II study of donepezil in irradiated brain tumor patients: Effect on cognitive function, mood, and quality of life
    • Shaw E.G., Rosdhal R., D'Agostino Jr. R.B., et al. Phase II study of donepezil in irradiated brain tumor patients: Effect on cognitive function, mood, and quality of life. J Clin Oncol 24 (2006) 1415-1420
    • (2006) J Clin Oncol , vol.24 , pp. 1415-1420
    • Shaw, E.G.1    Rosdhal, R.2    D'Agostino Jr., R.B.3
  • 15
    • 0034126973 scopus 로고    scopus 로고
    • The radioresponse of the central nervous system: A dynamic process
    • Tofilon P.J., and Fike J.R. The radioresponse of the central nervous system: A dynamic process. Radiat Res 153 (2000) 357-370
    • (2000) Radiat Res , vol.153 , pp. 357-370
    • Tofilon, P.J.1    Fike, J.R.2
  • 17
    • 0038330352 scopus 로고    scopus 로고
    • The rationale for adjuvant whole brain radiation therapy with radiosurgery in the treatment of single brain metastases
    • Patchell R.A., and Regine W.F. The rationale for adjuvant whole brain radiation therapy with radiosurgery in the treatment of single brain metastases. Technol Cancer Res Treat 2 (2003) 111-115
    • (2003) Technol Cancer Res Treat , vol.2 , pp. 111-115
    • Patchell, R.A.1    Regine, W.F.2
  • 18
    • 0027200693 scopus 로고
    • Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
    • Moser E., Moser M.B., and Andersen P. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J Neurosci 13 (1993) 3916-3925
    • (1993) J Neurosci , vol.13 , pp. 3916-3925
    • Moser, E.1    Moser, M.B.2    Andersen, P.3
  • 19
    • 0025681551 scopus 로고
    • Ibotenate lesions of hippocampus and/or subiculum: Dissociating components of allocentric spatial learning
    • Morris R.G., Schenk F., Tweedie F., et al. Ibotenate lesions of hippocampus and/or subiculum: Dissociating components of allocentric spatial learning. Eur J Neurosci 2 (1990) 1016-1028
    • (1990) Eur J Neurosci , vol.2 , pp. 1016-1028
    • Morris, R.G.1    Schenk, F.2    Tweedie, F.3
  • 20
    • 5144223971 scopus 로고    scopus 로고
    • Spatial memory, recognition memory, and the hippocampus
    • Broadbent N.J., Squire L.R., and Clark R.E. Spatial memory, recognition memory, and the hippocampus. Proc Natl Acad Sci U S A 101 (2004) 14515-14520
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14515-14520
    • Broadbent, N.J.1    Squire, L.R.2    Clark, R.E.3
  • 21
    • 0028820962 scopus 로고
    • Radiation-induced cognitive dysfunction: An experimental model in the old rat
    • Lamproglou I., Chen Q.M., Boisserie G., et al. Radiation-induced cognitive dysfunction: An experimental model in the old rat. Int J Radiat Oncol Biol Phys 31 (1995) 65-70
    • (1995) Int J Radiat Oncol Biol Phys , vol.31 , pp. 65-70
    • Lamproglou, I.1    Chen, Q.M.2    Boisserie, G.3
  • 22
    • 0033398652 scopus 로고    scopus 로고
    • An experimental study of radiation-induced cognitive dysfunction in an adult rat model
    • Yoneoka Y., Satoh M., Akiyama K., et al. An experimental study of radiation-induced cognitive dysfunction in an adult rat model. Br J Radiol 72 (1999) 1196-1201
    • (1999) Br J Radiol , vol.72 , pp. 1196-1201
    • Yoneoka, Y.1    Satoh, M.2    Akiyama, K.3
  • 23
    • 0038182466 scopus 로고    scopus 로고
    • Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
    • Madsen T.M., Kristjansen P.E., Bolwig T.G., et al. Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 119 (2003) 635-642
    • (2003) Neuroscience , vol.119 , pp. 635-642
    • Madsen, T.M.1    Kristjansen, P.E.2    Bolwig, T.G.3
  • 24
    • 0035798440 scopus 로고    scopus 로고
    • Radiation induced CNS toxicity-molecular and cellular mechanisms
    • Belka C., Budach W., Kortmann R.D., et al. Radiation induced CNS toxicity-molecular and cellular mechanisms. Br J Cancer 85 (2001) 1233-1239
    • (2001) Br J Cancer , vol.85 , pp. 1233-1239
    • Belka, C.1    Budach, W.2    Kortmann, R.D.3
  • 25
    • 34249792386 scopus 로고    scopus 로고
    • Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: A potential rat model of vascular dementia
    • Brown W.R., Blair R.M., Moody D.M., et al. Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: A potential rat model of vascular dementia. J Neurol Sci 257 (2007) 67-71
    • (2007) J Neurol Sci , vol.257 , pp. 67-71
    • Brown, W.R.1    Blair, R.M.2    Moody, D.M.3
  • 26
    • 0023696855 scopus 로고
    • Time- and dose-related changes in the white matter of the rat brain after single doses of X rays
    • Calvo W., Hopewell J.W., Reinhold H.S., et al. Time- and dose-related changes in the white matter of the rat brain after single doses of X rays. Br J Radiol 61 (1988) 1043-1052
    • (1988) Br J Radiol , vol.61 , pp. 1043-1052
    • Calvo, W.1    Hopewell, J.W.2    Reinhold, H.S.3
  • 27
    • 0025098304 scopus 로고
    • Development of blood vessel-related radiation damage in the fimbria of the central nervous system
    • Reinhold H.S., Calvo W., Hopewell J.W., et al. Development of blood vessel-related radiation damage in the fimbria of the central nervous system. Int J Radiat Oncol Biol Phys 18 (1990) 37-42
    • (1990) Int J Radiat Oncol Biol Phys , vol.18 , pp. 37-42
    • Reinhold, H.S.1    Calvo, W.2    Hopewell, J.W.3
  • 28
    • 0027265172 scopus 로고
    • Repair capacity of adult rat glial progenitor cells determined by an in vitro clonogenic assay after in vitro or in vivo fractionated irradiation
    • van der Maazen R.W., Kleiboer B.J., Verhagen I., et al. Repair capacity of adult rat glial progenitor cells determined by an in vitro clonogenic assay after in vitro or in vivo fractionated irradiation. Int J Radiat Biol 63 (1993) 661-666
    • (1993) Int J Radiat Biol , vol.63 , pp. 661-666
    • van der Maazen, R.W.1    Kleiboer, B.J.2    Verhagen, I.3
  • 29
    • 0032623244 scopus 로고    scopus 로고
    • Pathophysiological mechanisms leading to the development of late radiation-induced damage to the central nervous system
    • Hopewell J.W., and van der Kogel A.J. Pathophysiological mechanisms leading to the development of late radiation-induced damage to the central nervous system. Front Radiat Ther Oncol 33 (1999) 265-275
    • (1999) Front Radiat Ther Oncol , vol.33 , pp. 265-275
    • Hopewell, J.W.1    van der Kogel, A.J.2
  • 30
    • 0023105140 scopus 로고
    • Neuropsychologic impairment in adults with brain tumors
    • Maire J.P., Coudin B., Guerin J., et al. Neuropsychologic impairment in adults with brain tumors. Am J Clin Oncol 10 (1987) 156-162
    • (1987) Am J Clin Oncol , vol.10 , pp. 156-162
    • Maire, J.P.1    Coudin, B.2    Guerin, J.3
  • 31
    • 0027331199 scopus 로고
    • Gamma radiation (5-10 Gy) impairs neuronal function in the guinea pig hippocampus
    • Pellmar T.C., and Lepinski D.L. Gamma radiation (5-10 Gy) impairs neuronal function in the guinea pig hippocampus. Radiat Res 136 (1993) 255-261
    • (1993) Radiat Res , vol.136 , pp. 255-261
    • Pellmar, T.C.1    Lepinski, D.L.2
  • 32
    • 45849146096 scopus 로고
    • Brief summary of radiobiological principles in fractionated radiotherapy
    • Fowler J.F. Brief summary of radiobiological principles in fractionated radiotherapy. Semin Radiat Oncol 2 (1992) 16-21
    • (1992) Semin Radiat Oncol , vol.2 , pp. 16-21
    • Fowler, J.F.1
  • 33
    • 27444446186 scopus 로고    scopus 로고
    • Vascular damage after fractionated whole-brain irradiation in rats
    • Brown W.R., Thore C.R., Moody D.M., et al. Vascular damage after fractionated whole-brain irradiation in rats. Radiat Res 164 (2005) 662-668
    • (2005) Radiat Res , vol.164 , pp. 662-668
    • Brown, W.R.1    Thore, C.R.2    Moody, D.M.3
  • 34
    • 4744350870 scopus 로고    scopus 로고
    • Stereological quantification of GAD-67-immunoreactive neurons and boutons in the hippocampus of middle-aged and old Fischer 344 x Brown Norway rats
    • Shi L., Argenta A.E., Winseck A.K., et al. Stereological quantification of GAD-67-immunoreactive neurons and boutons in the hippocampus of middle-aged and old Fischer 344 x Brown Norway rats. J Comp Neurol 478 (2004) 282-291
    • (2004) J Comp Neurol , vol.478 , pp. 282-291
    • Shi, L.1    Argenta, A.E.2    Winseck, A.K.3
  • 35
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • West M.J., Slomianka L., and Gundersen H.J. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231 (1991) 482-497
    • (1991) Anat Rec , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 36
    • 33747167071 scopus 로고    scopus 로고
    • Maintenance of inhibitory interneurons and boutons in sensorimotor cortex between middle and old age in Fischer 344 X Brown Norway rats
    • Shi L., Pang H., Linville M.C., et al. Maintenance of inhibitory interneurons and boutons in sensorimotor cortex between middle and old age in Fischer 344 X Brown Norway rats. J Chem Neuroanat 32 (2006) 46-53
    • (2006) J Chem Neuroanat , vol.32 , pp. 46-53
    • Shi, L.1    Pang, H.2    Linville, M.C.3
  • 37
    • 0029821150 scopus 로고    scopus 로고
    • Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
    • Rapp P.R., and Gallagher M. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc Natl Acad Sci U S A 93 (1996) 9926-9930
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9926-9930
    • Rapp, P.R.1    Gallagher, M.2
  • 38
    • 84985280160 scopus 로고
    • The efficiency of systematic sampling in stereology and its prediction
    • Gundersen H.J., and Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. J Microsc 147 (1987) 229-263
    • (1987) J Microsc , vol.147 , pp. 229-263
    • Gundersen, H.J.1    Jensen, E.B.2
  • 39
    • 0023773176 scopus 로고
    • The role of prophylactic brain irradiation in limited stage small cell lung cancer: Clinical, neuropsychologic, and CT sequelae
    • Laukkanen E., Klonoff H., Allan B., et al. The role of prophylactic brain irradiation in limited stage small cell lung cancer: Clinical, neuropsychologic, and CT sequelae. Int J Radiat Oncol Biol Phys 14 (1988) 1109-1117
    • (1988) Int J Radiat Oncol Biol Phys , vol.14 , pp. 1109-1117
    • Laukkanen, E.1    Klonoff, H.2    Allan, B.3
  • 40
    • 3042787102 scopus 로고    scopus 로고
    • Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: Results of a randomized phase III trial
    • Meyers C.A., Smith J.A., Bezjak A., et al. Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: Results of a randomized phase III trial. J Clin Oncol 22 (2004) 157-165
    • (2004) J Clin Oncol , vol.22 , pp. 157-165
    • Meyers, C.A.1    Smith, J.A.2    Bezjak, A.3
  • 41
    • 0022372005 scopus 로고
    • Neurologic, neuropsychologic, and computed cranial tomography scan abnormalities in 2- to 10-year survivors of small-cell lung cancer
    • Johnson B.E., Becker B., Goff W.B., et al. Neurologic, neuropsychologic, and computed cranial tomography scan abnormalities in 2- to 10-year survivors of small-cell lung cancer. J Clin Oncol 3 (1985) 1659-1667
    • (1985) J Clin Oncol , vol.3 , pp. 1659-1667
    • Johnson, B.E.1    Becker, B.2    Goff, W.B.3
  • 42
    • 0017856079 scopus 로고
    • Radiation necrosis of the brain: Correlation between computed tomography, pathology, and dose distribution
    • Mikhael M.A. Radiation necrosis of the brain: Correlation between computed tomography, pathology, and dose distribution. J Comput Assist Tomogr 2 (1978) 71-80
    • (1978) J Comput Assist Tomogr , vol.2 , pp. 71-80
    • Mikhael, M.A.1
  • 43
    • 0016723322 scopus 로고
    • The anatomy of the late radiation encephalopathy
    • De Reuck J., and Vander E.H. The anatomy of the late radiation encephalopathy. Eur Neurol 13 (1975) 481-494
    • (1975) Eur Neurol , vol.13 , pp. 481-494
    • De Reuck, J.1    Vander, E.H.2
  • 44
    • 0029745387 scopus 로고    scopus 로고
    • Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons
    • Enokido Y., Araki T., Tanaka K., et al. Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons. Eur J Neurosci 8 (1996) 1812-1821
    • (1996) Eur J Neurosci , vol.8 , pp. 1812-1821
    • Enokido, Y.1    Araki, T.2    Tanaka, K.3
  • 45
    • 0031975026 scopus 로고    scopus 로고
    • Response of postmitotic neurons to X-irradiation: Implications for the role of DNA damage in neuronal apoptosis
    • Gobbel G.T., Bellinzona M., Vogt A.R., et al. Response of postmitotic neurons to X-irradiation: Implications for the role of DNA damage in neuronal apoptosis. J Neurosci 18 (1998) 147-155
    • (1998) J Neurosci , vol.18 , pp. 147-155
    • Gobbel, G.T.1    Bellinzona, M.2    Vogt, A.R.3
  • 46
    • 0032550125 scopus 로고    scopus 로고
    • Astrocytes protect against X-ray-induced neuronal toxicity in vitro
    • Noel F., and Tofilon P.J. Astrocytes protect against X-ray-induced neuronal toxicity in vitro. Neuroreport 9 (1998) 1133-1137
    • (1998) Neuroreport , vol.9 , pp. 1133-1137
    • Noel, F.1    Tofilon, P.J.2
  • 47
    • 0036718268 scopus 로고    scopus 로고
    • Altered spatial arrangement of layer V pyramidal cells in the mouse brain following prenatal low-dose X-irradiation. A stereological study using a novel three-dimensional analysis method to estimate the nearest neighbor distance distributions of cells in thick sections
    • Schmitz C., Grolms N., Hof P.R., et al. Altered spatial arrangement of layer V pyramidal cells in the mouse brain following prenatal low-dose X-irradiation. A stereological study using a novel three-dimensional analysis method to estimate the nearest neighbor distance distributions of cells in thick sections. Cereb Cortex 12 (2002) 954-960
    • (2002) Cereb Cortex , vol.12 , pp. 954-960
    • Schmitz, C.1    Grolms, N.2    Hof, P.R.3
  • 48
    • 0013784893 scopus 로고
    • Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
    • Altman J., and Das G.D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 124 (1965) 319-335
    • (1965) J Comp Neurol , vol.124 , pp. 319-335
    • Altman, J.1    Das, G.D.2
  • 49
    • 0015868334 scopus 로고
    • Time of neuron origin in the hippocampus and dentate gyrus of normal and reeler mutant mice: An autoradiographic analysis
    • Caviness Jr. V.S. Time of neuron origin in the hippocampus and dentate gyrus of normal and reeler mutant mice: An autoradiographic analysis. J Comp Neurol 151 (1973) 113-120
    • (1973) J Comp Neurol , vol.151 , pp. 113-120
    • Caviness Jr., V.S.1
  • 50
    • 0037471433 scopus 로고    scopus 로고
    • Hippocampal cell genesis does not correlate with spatial learning ability in aged rats
    • Merrill D.A., Karim R., Darraq M., et al. Hippocampal cell genesis does not correlate with spatial learning ability in aged rats. J Comp Neurol 459 (2003) 201-207
    • (2003) J Comp Neurol , vol.459 , pp. 201-207
    • Merrill, D.A.1    Karim, R.2    Darraq, M.3
  • 51
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • van Praag H., Shubert T., Zhao C., et al. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25 (2005) 8680-8685
    • (2005) J Neurosci , vol.25 , pp. 8680-8685
    • van Praag, H.1    Shubert, T.2    Zhao, C.3
  • 52
    • 0035479759 scopus 로고    scopus 로고
    • Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats
    • Merrill D.A., Chiba A.A., and Tuszynski M.H. Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats. J Comp Neurol 438 (2001) 445-456
    • (2001) J Comp Neurol , vol.438 , pp. 445-456
    • Merrill, D.A.1    Chiba, A.A.2    Tuszynski, M.H.3
  • 53
    • 0035965708 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
    • Lichtenwalner R.J., Forbes M.E., Bennett S.A., et al. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 107 (2001) 603-613
    • (2001) Neuroscience , vol.107 , pp. 603-613
    • Lichtenwalner, R.J.1    Forbes, M.E.2    Bennett, S.A.3
  • 54
    • 0042668324 scopus 로고    scopus 로고
    • Production of new cells in the rat dentate gyrus over the lifespan: Relation to cognitive decline
    • Bizon J.L., and Gallagher M. Production of new cells in the rat dentate gyrus over the lifespan: Relation to cognitive decline. Eur J Neurosci 18 (2003) 215-219
    • (2003) Eur J Neurosci , vol.18 , pp. 215-219
    • Bizon, J.L.1    Gallagher, M.2
  • 55
    • 39049086174 scopus 로고    scopus 로고
    • Aging-dependent changes in normal brain tissue response to whole brain irradiation
    • Schindler M.K., Forbes M.E., and Riddle D.R. Aging-dependent changes in normal brain tissue response to whole brain irradiation. Int J Radiat Oncol Biol Phys 70 (2008) 826-834
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 826-834
    • Schindler, M.K.1    Forbes, M.E.2    Riddle, D.R.3
  • 56
    • 3042799716 scopus 로고    scopus 로고
    • Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    • Rola R., Raber J., Rizk A., et al. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp Neurol 188 (2004) 316-330
    • (2004) Exp Neurol , vol.188 , pp. 316-330
    • Rola, R.1    Raber, J.2    Rizk, A.3
  • 57
    • 3843075154 scopus 로고    scopus 로고
    • Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    • Raber J., Rola R., LeFevour A., et al. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res 162 (2004) 39-47
    • (2004) Radiat Res , vol.162 , pp. 39-47
    • Raber, J.1    Rola, R.2    LeFevour, A.3
  • 58
    • 6344254741 scopus 로고    scopus 로고
    • Cognitive sequelae of brain radiation in adults
    • Laack N.N., and Brown P.D. Cognitive sequelae of brain radiation in adults. Semin Oncol 31 (2004) 702-713
    • (2004) Semin Oncol , vol.31 , pp. 702-713
    • Laack, N.N.1    Brown, P.D.2
  • 59
    • 3543113767 scopus 로고    scopus 로고
    • A critical review of the clinical effects of therapeutic irradiation damage to the brain: the roots of controversy
    • Armstrong C.L., Gyato K., Awadalla A.W., et al. A critical review of the clinical effects of therapeutic irradiation damage to the brain: the roots of controversy. Neuropsychol Rev 14 (2004) 65-86
    • (2004) Neuropsychol Rev , vol.14 , pp. 65-86
    • Armstrong, C.L.1    Gyato, K.2    Awadalla, A.W.3
  • 60
    • 0035681270 scopus 로고    scopus 로고
    • Cognitive dysfunction and histological findings in adult rats one year after whole brain irradiation
    • Akiyama K., Tanaka R., Sato M., et al. Cognitive dysfunction and histological findings in adult rats one year after whole brain irradiation. Neurol Med Chir (Tokyo) 41 (2001) 590-598
    • (2001) Neurol Med Chir (Tokyo) , vol.41 , pp. 590-598
    • Akiyama, K.1    Tanaka, R.2    Sato, M.3
  • 61
    • 0032033535 scopus 로고    scopus 로고
    • Late behavioural and neuropathological effects of local brain irradiation in the rat
    • Hodges H., Katzung N., Sowinski P., et al. Late behavioural and neuropathological effects of local brain irradiation in the rat. Behav Brain Res 91 (1998) 99-114
    • (1998) Behav Brain Res , vol.91 , pp. 99-114
    • Hodges, H.1    Katzung, N.2    Sowinski, P.3
  • 62
    • 1642499459 scopus 로고    scopus 로고
    • Early radiation-induced endothelial cell loss and blood-spinal cord barrier breakdown in the rat spinal cord
    • Li Y.Q., Chen P., Jain V., et al. Early radiation-induced endothelial cell loss and blood-spinal cord barrier breakdown in the rat spinal cord. Radiat Res 161 (2004) 143-152
    • (2004) Radiat Res , vol.161 , pp. 143-152
    • Li, Y.Q.1    Chen, P.2    Jain, V.3
  • 63
    • 0028363279 scopus 로고
    • Disruption of the blood-brain barrier as the primary effect of CNS irradiation
    • Rubin P., Gash D.M., Hansen J.T., et al. Disruption of the blood-brain barrier as the primary effect of CNS irradiation. Radiother Oncol 31 (1994) 51-60
    • (1994) Radiother Oncol , vol.31 , pp. 51-60
    • Rubin, P.1    Gash, D.M.2    Hansen, J.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.