A cyclopentanediol analogue selectively suppresses the conserved innate immunity pathways, Drosophila IMD and TNF-α pathways

Biochemical Pharmacology

Volumn 75, Issue 11, 2008, Pages 2165-2174

  Sekiya, Mizuki ^a   Ueda, Kazunori ^a   Okazaki, Kaori ^a   Kikuchi, Haruhisa ^a   Kurata, Shoichiro ^a   Oshima, Yoshiteru ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Cyclopentanediol analogue; Drosophila; Immune suppressor; Innate immunity; NF B; TAK1 kinase

Indexed keywords

CYCLOPENTANEDIOL DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ASPERGILLUS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOREACTIVITY; IN VIVO STUDY; INNATE IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ALLYL COMPOUNDS; ANIMALS; ASPERGILLUS; CELLS, CULTURED; CYCLOPENTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOTHELIAL CELLS; HUMANS; IMMUNITY, NATURAL; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1BETA; LARVA; MAP KINASE KINASE KINASES; MOLECULAR STRUCTURE; NF-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 43049130703     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.12.020     Document Type: Article

References (33)

1. Takeda K., and Akira S. Toll-like receptors in innate immunity. Int Immunol 17 (2005) 1-14
2. Hoffmann J.A., and Reichhart J.M. Drosophila innate immunity: an evolutionary perspective. Nat Immunol 3 (2002) 121-126
3. Janeway Jr. C.A. How the immune system works to protect the host from infection: a personal view. Proc Natl Acad Sci USA 98 (2001) 7461-7468
4. Hultmark D. Drosophila immunity: paths and patterns. Curr Opin Immunol 15 (2003) 12-19
5. Ferrandon D., Imler J.L., and Hoffmann J.A. Sensing infection in Drosophila: Toll and beyond. Semin Immunol 16 (2004) 43-53
6. Silverman N., and Maniatis T. NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev 15 (2001) 2321-2342
7. Royet J., Reichhart J.M., and Hoffmann J.A. Sensing and signaling during infection in Drosophila. Curr Opin Immunol 17 (2005) 11-17
8. Yajima M., Takada M., Takahashi N., Kikuchi H., Natori S., Oshima Y., et al. A newly established in vitro culture using transgenic Drosophila reveals functional coupling between the phospholipase A2-generated fatty acid cascade and lipopolysaccharide-dependent activation of the immune deficiency (imd) pathway in insect immunity. Biochem J 371 (2003) 205-210
9. Sekiya M., Ueda K., Fujita T., Kitayama M., Kikuchi H., Oshima Y., et al. Establishment of ex vivo systems to identify compounds acting on innate immune responses and to determine their target molecules using transgenic Drosophila. Life Sci 80 (2006) 113-119
10. Choe K.M., Werner T., Stoven S., Hultmark D., and Anderson K.V. Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science 296 (2002) 359-362
11. Georgel P., Naitza S., Kappler C., Ferrandon D., Zachary D., Swimmer C., et al. Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev Cell 1 (2001) 503-514
12. Khush R.S., Cornwell W.D., Uram J.N., and Lemaitre B. A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade. Curr Biol 12 (2002) 1728-1737
13. Takatsu Y., Nakamura M., Stapleton M., Danos M.C., Matsumoto K., O'Connor M.B., et al. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol Cell Biol 20 (2000) 3015-3026
14. Kaneko T., Goldman W.E., Mellroth P., Steiner H., Fukase K., Kusumoto S., et al. Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity 20 (2004) 637-649
15. Ghisalberti E.L., Narbey M.J., and Rowland C.Y. Metabolites of Aspergillus-Terreus antagonistic towards the take-all fungus. J Nat Prod 53 (1990) 520-522
16. Hedengren M., Asling B., Dushay M.S., Ando I., Ekengren S., Wihlborg M., et al. Relish, a central factor in the control of humoral but not cellular immunity in Drosophila. Mol Cell 4 (1999) 827-837
17. Leulier F., Parquet C., Pili-Floury S., Ryu J.H., Caroff M., Lee W.J., et al. The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat Immunol 4 (2003) 478-484
18. Takehana A., Yano T., Mita S., Kotani A., Oshima Y., and Kurata S. Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity. EMBO J 23 (2004) 4690-4700
19. Ramet M., Manfruelli P., Pearson A., Mathey-Prevot B., and Ezekowitz R.A. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 416 (2002) 644-648
20. Hehlgans T., and Pfeffer K. The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology 115 (2005) 1-20
21. Karin M., Yamamoto Y., and Wang Q.M. The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov 3 (2004) 17-26
22. Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., and Chen Z.J. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412 (2001) 346-351
23. Tada K., Okazaki T., Sakon S., Kobarai T., Kurosawa K., Yamaoka S., et al. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem 276 (2001) 36530-36534
24. Takaesu G., Surabhi R.M., Park K.J., Ninomiya-Tsuji J., Matsumoto K., and Gaynor R.B. TAK1 is critical for I kappa B kinase-mediated activation of the NF-kappa B pathway. J Mol Biol 326 (2003) 105-115
25. Ishitani T., Takaesu G., Ninomiya-Tsuji J., Shibuya H., Gaynor R.B., and Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signalling. EMBO J 22 (2003) 6277-6288
26. MacRae C.A., and Peterson R.T. Zebrafish-based small molecule discovery. Chem Biol 10 (2003) 901-908
27. Parsons A.B., Lopez A., Givoni I.E., Williams D.E., Gray C.A., Porter J., et al. Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell 126 (2006) 611-625
28. Kwok T.C., Ricker N., Fraser R., Chan A.W., Burns A., Stanley E.F., et al. A small-molecule screen in C. elegans yields a new calcium channel antagonist. Nature 441 (2006) 91-95
29. Frolet C., Thoma M., Blandin S., Hoffmann J.A., and Levashina E.A. Boosting NF-kappaB-dependent basal immunity of Anopheles gambiae aborts development of Plasmodium berghei. Immunity 25 (2006) 677-685
30. Meister S., Kanzok S.M., Zheng X.L., Luna C., Li T.R., Hoa N.T., et al. Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae. Proc Natl Acad Sci USA 102 (2005) 11420-11425
31. Hu C., and Aksoy S. Innate immune responses regulate trypanosome parasite infection of the tsetse fly Glossina morsitans morsitans. Mol Microbiol 60 (2006) 1194-1204
32. Zhou R., Silverman N., Hong M., Liao D.S., Chung Y., Chen Z.J., et al. The role of ubiquitination in Drosophila innate immunity. J Biol Chem 280 (2005) 34048-34055
33. Adhikari A., Xu M., and Chen Z.J. Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 26 (2007) 3214-3226