Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: Possible ionic mechanism

Basic Research in Cardiology

Volumn 97, Issue 4, 2002, Pages 295-304

  Martynyuk, Anatoly E ^b   Zima, Aleksey ^b   Seubert, Christoph N ^c   Morey, Timothy E ^b   Belardinelli, Luiz ^d   Dennis, Donn M ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b Department of Anesthesiology ^*  (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d CV THERAPEUTICS INC   (United States)

Author keywords

Adenosine; Atrioventricular node; Heart rate; K + channels; PD 81,723

Indexed keywords

2 AMINO 4,5 DIMETHYL 3 (3 TRIFLUOROMETHYLBENZOYL)THIOPHENE; 8 BROMO CYCLIC AMP; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; BARIUM ION; CHROMANOL 293B; POTASSIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; POTASSIUM; POTASSIUM CHANNEL; THIOPHENE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CHANNEL GATING; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIVITY; GUINEA PIG; HEART ATRIUM CONDUCTION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; HIS BUNDLE POTENTIAL; ION CURRENT; ISOLATED HEART; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; TIME; ANIMAL; CELL MEMBRANE POTENTIAL; CYTOLOGY; ELECTROSTIMULATION; HEART ATRIOVENTRICULAR NODE; METABOLISM; PHYSIOLOGY;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADENOSINE; ANIMAL; ATRIOVENTRICULAR NODE; DRUG SYNERGISM; ELECTRIC STIMULATION; GUINEA PIGS; HEART RATE; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; POTASSIUM; POTASSIUM CHANNELS; SUPPORT, NON-U.S. GOV'T; THIOPHENES; ANIMALS;

EID: 0035997540     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-002-0354-y     Document Type: Article

References (27)

1. The cardiac effects of adenosine
2. 1-adenosine receptor agonist in guinea pig isolated heart
3. Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes
4. + current, on repolarization in human and guinea pig ventricular myocytes
5. 1 receptors
6. Ionic basis and analytical solution of the wenckebach phenomenon in guinea pig ventricular myocytes
7. Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart
8. Species-dependent effects of adenosine on heart rate and atrioventricular nodal conduction. Mechanism and physiological implications
9. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
10. A method for isolating rabbit atrioventricular node myocytes which retain normal morphology and function
11. 2+-induced ventricular automaticity
12. r
13. Rate-dependent properties of adenosine-induced negative dromotropism in humans
14. Cardiac electrophysiology of adenosine. Basic and clinical concepts
15. Adenosine increases potassium conductance in isolated rabbit atrioventricular nodal myocytes
16. Role of nitric oxide, cyclic GMP and superoxide in inhibition by adenosine of calcium current in rabbit atrioventricular nodal cells
17. K,ADO in rabbit isolated AV nodal myocytes and on AV nodal conduction in guinea pig isolated heart
18. K,ADO to the negative dromotropic effect of adenosine
19. + current in rabbit atrial myocytes
20. Effects of adenosine on rate-dependent atrioventricular nodal function. Potential roles in tachycardia termination and physiological regulation
21. Resting K conductances in pacemaker and non-pacemaker heart cells of the rabbit
22. 1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig
23. Cellular basis for the negative dromotropic effect of adenosine on rabbit single atrioventricular nodal cells
24. Abnormal heart rate regulation in GIRK4 knockout mice
25. Ionic basis of a differential effect of adenosine on refractoriness in rabbit AV nodal and atrial isolated myocytes
26. Barium block of the muscarinic potassium current in guinea-pig atrial cells
27. Antagonism of the positive dromotropic effect of isoproterenol by adenosine: Role of nitric oxide, cGMP-dependent cAMP-phosphodiesterase and protein kinase G