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Volumn 153, Issue 3, 2008, Pages 618-633

Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease

Author keywords

cholinergic stimulation; ERK; immunohistochemistry; JNK; p38MAPK

Indexed keywords

ENZYME ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

EID: 43049118551     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.02.061     Document Type: Article
Times cited : (30)

References (85)
  • 2
    • 0036178441 scopus 로고    scopus 로고
    • Molecular psychology: roles for the ERK MAP kinase cascade in memory
    • J.P. Adams J.D. Sweatt Molecular psychology: roles for the ERK MAP kinase cascade in memory Annu Rev Pharmacol Toxicol 42 2002 135 163
    • (2002) Annu Rev Pharmacol Toxicol , vol.42 , pp. 135-163
    • Adams, J.P.1    Sweatt, J.D.2
  • 4
    • 0035208849 scopus 로고    scopus 로고
    • Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis
    • C. Atzori B. Ghetti R. Piva A.N. Srinivasan P. Zolo M.B. Delisle S.S. Mirra A. Migheli Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis J Neuropathol Exp Neurol 60 2001 1190 1197
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 1190-1197
    • Atzori, C.1    Ghetti, B.2    Piva, R.3    Srinivasan, A.N.4    Zolo, P.5    Delisle, M.B.6    Mirra, S.S.7    Migheli, A.8
  • 5
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • R.T. Bartus R.L. Dean B. Beer A.S. Lippa The cholinergic hypothesis of geriatric memory dysfunction Science 217 1982 408 417
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 8
    • 0035543554 scopus 로고    scopus 로고
    • M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices
    • J.L. Berkeley J. Gomeza J. Wess S.E. Hamilton N.M. Nathanson A.I. Levey M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices Mol Cell Neurosci 18 2001 512 524
    • (2001) Mol Cell Neurosci , vol.18 , pp. 512-524
    • Berkeley, J.L.1    Gomeza, J.2    Wess, J.3    Hamilton, S.E.4    Nathanson, N.M.5    Levey, A.I.6
  • 9
    • 0032402195 scopus 로고    scopus 로고
    • Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat
    • D.E. Berman S. Hazvi K. Rosenblum R. Seger Y. Dudai Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat J Neurosci 18 1998 10037 10044
    • (1998) J Neurosci , vol.18 , pp. 10037-10044
    • Berman, D.E.1    Hazvi, S.2    Rosenblum, K.3    Seger, R.4    Dudai, Y.5
  • 10
    • 0033135345 scopus 로고    scopus 로고
    • A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory
    • S. Blum A.N. Moore F. Adams P.K. Dash A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory J Neurosci 19 1999 3535 3544
    • (1999) J Neurosci , vol.19 , pp. 3535-3544
    • Blum, S.1    Moore, A.N.2    Adams, F.3    Dash, P.K.4
  • 12
    • 8744276616 scopus 로고    scopus 로고
    • Amyloid beta-peptide(1–42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain
    • D.A. Butterfield D. Boyd-Kimball Amyloid beta-peptide(1–42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain Brain Pathol 14 2004 426 432
    • (2004) Brain Pathol , vol.14 , pp. 426-432
    • Butterfield, D.A.1    Boyd-Kimball, D.2
  • 14
    • 0034629007 scopus 로고    scopus 로고
    • Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade
    • M. Cammarota L.R. Bevilaqua P. Ardenghi G. Paratcha D.S. Levi I. Izquierdo J.H. Medina Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade Brain Res Mol Brain Res 76 2000 36 46
    • (2000) Brain Res Mol Brain Res , vol.76 , pp. 36-46
    • Cammarota, M.1    Bevilaqua, L.R.2    Ardenghi, P.3    Paratcha, G.4    Levi, D.S.5    Izquierdo, I.6    Medina, J.H.7
  • 15
    • 0032078872 scopus 로고    scopus 로고
    • A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II
    • H.J. Chen M. Rojas-Soto A. Oguni M.B. Kennedy A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II Neuron 20 1998 895 904
    • (1998) Neuron , vol.20 , pp. 895-904
    • Chen, H.J.1    Rojas-Soto, M.2    Oguni, A.3    Kennedy, M.B.4
  • 17
    • 33646198145 scopus 로고    scopus 로고
    • Tau therapeutic strategies for the treatment of Alzheimer's disease
    • I. Churcher Tau therapeutic strategies for the treatment of Alzheimer's disease Curr Top Med Chem 6 2006 579 595
    • (2006) Curr Top Med Chem , vol.6 , pp. 579-595
    • Churcher, I.1
  • 18
    • 0032588943 scopus 로고    scopus 로고
    • Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells
    • K.C. Corbit D.A. Foster M.R. Rosner Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells Mol Cell Biol 19 1999 4209 4218
    • (1999) Mol Cell Biol , vol.19 , pp. 4209-4218
    • Corbit, K.C.1    Foster, D.A.2    Rosner, M.R.3
  • 20
    • 0035875962 scopus 로고    scopus 로고
    • Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease
    • K.T. Dineley M. Westerman D. Bui K. Bell K.H. Ashe J.D. Sweatt Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease J Neurosci 21 2001 4125 4133
    • (2001) J Neurosci , vol.21 , pp. 4125-4133
    • Dineley, K.T.1    Westerman, M.2    Bui, D.3    Bell, K.4    Ashe, K.H.5    Sweatt, J.D.6
  • 22
    • 0035668350 scopus 로고    scopus 로고
    • Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and dementia with Lewy bodies
    • I. Ferrer R. Blanco M. Carmona B. Puig M. Barrachina C. Gomez S. Ambrosio Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and dementia with Lewy bodies J Neural Transm 108 2001 1383 1396
    • (2001) J Neural Transm , vol.108 , pp. 1383-1396
    • Ferrer, I.1    Blanco, R.2    Carmona, M.3    Puig, B.4    Barrachina, M.5    Gomez, C.6    Ambrosio, S.7
  • 23
    • 25844458239 scopus 로고    scopus 로고
    • Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies
    • I. Ferrer T. Gomez-Isla B. Puig M. Freixes E. Ribe E. Dalfo J. Avila Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies Curr Alzheimer Res 2 2005 3 18
    • (2005) Curr Alzheimer Res , vol.2 , pp. 3-18
    • Ferrer, I.1    Gomez-Isla, T.2    Puig, B.3    Freixes, M.4    Ribe, E.5    Dalfo, E.6    Avila, J.7
  • 24
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
    • C. Geula C.K. Wu D. Saroff A. Lorenzo M. Yuan B.A. Yankner Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity Nat Med 4 1998 827 831
    • (1998) Nat Med , vol.4 , pp. 827-831
    • Geula, C.1    Wu, C.K.2    Saroff, D.3    Lorenzo, A.4    Yuan, M.5    Yankner, B.A.6
  • 25
    • 33846437825 scopus 로고    scopus 로고
    • The role of the extracellular signal-regulated kinase pathway in memory encoding
    • M.G. Giovannini The role of the extracellular signal-regulated kinase pathway in memory encoding Rev Neurosci 17 2006 619 634
    • (2006) Rev Neurosci , vol.17 , pp. 619-634
    • Giovannini, M.G.1
  • 29
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • F. Gonzalez-Scarano G. Baltuch Microglia as mediators of inflammatory and degenerative diseases Annu Rev Neurosci 22 1999 219 240
    • (1999) Annu Rev Neurosci , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 30
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
    • J. Gotz F. Chen J. van Dorpe R.M. Nitsch Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils Science 293 2001 1491 1495
    • (2001) Science , vol.293 , pp. 1491-1495
    • Gotz, J.1    Chen, F.2    van Dorpe, J.3    Nitsch, R.M.4
  • 31
    • 0032861127 scopus 로고    scopus 로고
    • Extracellular-signal-regulated kinase signalling in neurons
    • S.S. Grewal R.D. York P.J. Stork Extracellular-signal-regulated kinase signalling in neurons Curr Opin Neurobiol 9 1999 544 553
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 544-553
    • Grewal, S.S.1    York, R.D.2    Stork, P.J.3
  • 32
    • 0029945349 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK) activation by butylated hydroxytoluene hydroperoxide: implications for cellular survival and tumor promotion
    • K.Z. Guyton M. Gorospe T.W. Kensler N.J. Holbrook Mitogen-activated protein kinase (MAPK) activation by butylated hydroxytoluene hydroperoxide: implications for cellular survival and tumor promotion Cancer Res 56 1996 3480 3485
    • (1996) Cancer Res , vol.56 , pp. 3480-3485
    • Guyton, K.Z.1    Gorospe, M.2    Kensler, T.W.3    Holbrook, N.J.4
  • 33
    • 4243146359 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases and the evolution of Alzheimer's: a revolutionary neurogenetic axis for therapeutic intervention?
    • J.J. Haddad Mitogen-activated protein kinases and the evolution of Alzheimer's: a revolutionary neurogenetic axis for therapeutic intervention? Prog Neurobiol 73 2004 359 377
    • (2004) Prog Neurobiol , vol.73 , pp. 359-377
    • Haddad, J.J.1
  • 34
    • 0028908516 scopus 로고
    • Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1–40) in cultured hippocampal neurons
    • M.E. Harris K. Hensley D.A. Butterfield R.A. Leedle J.M. Carney Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1–40) in cultured hippocampal neurons Exp Neurol 131 1995 193 202
    • (1995) Exp Neurol , vol.131 , pp. 193-202
    • Harris, M.E.1    Hensley, K.2    Butterfield, D.A.3    Leedle, R.A.4    Carney, J.M.5
  • 36
    • 0033529638 scopus 로고    scopus 로고
    • Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
    • M. Hetman K. Kanning J.E. Cavanaugh Z. Xia Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase J Biol Chem 274 1999 22569 22580
    • (1999) J Biol Chem , vol.274 , pp. 22569-22580
    • Hetman, M.1    Kanning, K.2    Cavanaugh, J.E.3    Xia, Z.4
  • 38
    • 0036230270 scopus 로고    scopus 로고
    • Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs
    • M. Hull K. Lieb B.L. Fiebich Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs Curr Med Chem 9 2002 83 88
    • (2002) Curr Med Chem , vol.9 , pp. 83-88
    • Hull, M.1    Lieb, K.2    Fiebich, B.L.3
  • 40
    • 23844522383 scopus 로고    scopus 로고
    • Early changes in behavior deficits, amyloid beta-42 deposits and MAPK activation in doubly transgenic mice co-expressing NSE-controlled human mutant PS2 and APPsw
    • D.Y. Hwang J.S. Cho J.H. Oh S.B. Shim S.W. Jee S.H. Lee S.J. Seo C.W. Song S.H. Lee Y.K. Kim Early changes in behavior deficits, amyloid beta-42 deposits and MAPK activation in doubly transgenic mice co-expressing NSE-controlled human mutant PS2 and APPsw Cell Mol Neurobiol 25 2005 881 898
    • (2005) Cell Mol Neurobiol , vol.25 , pp. 881-898
    • Hwang, D.Y.1    Cho, J.S.2    Oh, J.H.3    Shim, S.B.4    Jee, S.W.5    Lee, S.H.6    Seo, S.J.7    Song, C.W.8    Lee, S.H.9    Kim, Y.K.10
  • 43
    • 29144511607 scopus 로고    scopus 로고
    • MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits
    • B. Kaminska MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits Biochim Biophys Acta 1754 2005 253 262
    • (2005) Biochim Biophys Acta , vol.1754 , pp. 253-262
    • Kaminska, B.1
  • 44
    • 0032794221 scopus 로고    scopus 로고
    • Rapid phosphorylation of Elk-1 transcription factor and activation of MAP kinase signal transduction pathways in response to visual stimulation
    • B. Kaminska L. Kaczmarek S. Zangenehpour A. Chaudhuri Rapid phosphorylation of Elk-1 transcription factor and activation of MAP kinase signal transduction pathways in response to visual stimulation Mol Cell Neurosci 13 1999 405 414
    • (1999) Mol Cell Neurosci , vol.13 , pp. 405-414
    • Kaminska, B.1    Kaczmarek, L.2    Zangenehpour, S.3    Chaudhuri, A.4
  • 45
    • 1342322145 scopus 로고    scopus 로고
    • Translational control by MAPK signaling in long-term synaptic plasticity and memory
    • R.J. Kelleher III A. Govindarajan H.Y. Jung H. Kang S. Tonegawa Translational control by MAPK signaling in long-term synaptic plasticity and memory Cell 116 2004 467 479
    • (2004) Cell , vol.116 , pp. 467-479
    • Kelleher, R.J.1    Govindarajan, A.2    Jung, H.Y.3    Kang, H.4    Tonegawa, S.5
  • 46
    • 33748371203 scopus 로고    scopus 로고
    • An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin
    • T.K. Khan D.L. Alkon An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin Proc Natl Acad Sci U S A 103 2006 13203 13207
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13203-13207
    • Khan, T.K.1    Alkon, D.L.2
  • 47
    • 0032055396 scopus 로고    scopus 로고
    • SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family
    • J.H. Kim D. Liao L.F. Lau R.L. Huganir SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family Neuron 20 1998 683 691
    • (1998) Neuron , vol.20 , pp. 683-691
    • Kim, J.H.1    Liao, D.2    Lau, L.F.3    Huganir, R.L.4
  • 48
    • 0030808984 scopus 로고    scopus 로고
    • Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
    • J.L. Kummer P.K. Rao K.A. Heidenreich Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase J Biol Chem 272 1997 20490 20494
    • (1997) J Biol Chem , vol.272 , pp. 20490-20494
    • Kummer, J.L.1    Rao, P.K.2    Heidenreich, K.A.3
  • 50
    • 0032733691 scopus 로고    scopus 로고
    • The role of oxidative stress in Alzheimer disease
    • W.R. Markesbery The role of oxidative stress in Alzheimer disease Arch Neurol 56 1999 1449 1452
    • (1999) Arch Neurol , vol.56 , pp. 1449-1452
    • Markesbery, W.R.1
  • 51
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation
    • C.J. Marshall Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation Cell 80 1995 179 185
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 52
    • 0029813177 scopus 로고    scopus 로고
    • Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease
    • E. Masliah A. Sisk M. Mallory L. Mucke D. Schenk D. Games Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease J Neurosci 16 1996 5796 5811
    • (1996) J Neurosci , vol.16 , pp. 5796-5811
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Mucke, L.4    Schenk, D.5    Games, D.6
  • 53
    • 0021044702 scopus 로고
    • Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6)
    • M.M. Mesulam E.J. Mufson B.H. Vainer A.I. Levey Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6) Neuroscience 10 1983 1185 1201
    • (1983) Neuroscience , vol.10 , pp. 1185-1201
    • Mesulam, M.M.1    Mufson, E.J.2    Vainer, B.H.3    Levey, A.I.4
  • 54
    • 0035478618 scopus 로고    scopus 로고
    • Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand
    • Y. Morishima Y. Gotoh J. Zieg T. Barrett H. Takano R. Flavell R.J. Davis Y. Shirasaki M.E. Greenberg Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand J Neurosci 21 2001 7551 7560
    • (2001) J Neurosci , vol.21 , pp. 7551-7560
    • Morishima, Y.1    Gotoh, Y.2    Zieg, J.3    Barrett, T.4    Takano, H.5    Flavell, R.6    Davis, R.J.7    Shirasaki, Y.8    Greenberg, M.E.9
  • 55
    • 0032578510 scopus 로고    scopus 로고
    • Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity
    • B. Murray A. Alessandrini A.J. Cole A.G. Yee E.J. Furshpan Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity Proc Natl Acad Sci U S A 95 1998 11975 11980
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11975-11980
    • Murray, B.1    Alessandrini, A.2    Cole, A.J.3    Yee, A.G.4    Furshpan, E.J.5
  • 56
    • 0034773788 scopus 로고    scopus 로고
    • Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase
    • S.L. Patterson C. Pittenger A. Morozov K.C. Martin H. Scanlin C. Drake E.R. Kandel Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase Neuron 32 2001 123 140
    • (2001) Neuron , vol.32 , pp. 123-140
    • Patterson, S.L.1    Pittenger, C.2    Morozov, A.3    Martin, K.C.4    Scanlin, H.5    Drake, C.6    Kandel, E.R.7
  • 58
    • 2442765165 scopus 로고
    • Brain acetylcholine: an inventory of our knowledge on the 50th anniversary of its discovery
    • G. Pepeu Brain acetylcholine: an inventory of our knowledge on the 50th anniversary of its discovery Trends Pharmacol Sci 4 1983 416 418
    • (1983) Trends Pharmacol Sci , vol.4 , pp. 416-418
    • Pepeu, G.1
  • 59
    • 0018078940 scopus 로고
    • Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
    • E.K. Perry B.E. Tomlinson G. Blessed K. Bergman P.H. Gibson R.H. Perry Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia BMJ 2 1978 1457 1459
    • (1978) BMJ , vol.2 , pp. 1457-1459
    • Perry, E.K.1    Tomlinson, B.E.2    Blessed, G.3    Bergman, K.4    Gibson, P.H.5    Perry, R.H.6
  • 60
    • 0036709020 scopus 로고    scopus 로고
    • Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling
    • J. Pouyssegur V. Volmat P. Lenormand Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling Biochem Pharmacol 64 2002 755 763
    • (2002) Biochem Pharmacol , vol.64 , pp. 755-763
    • Pouyssegur, J.1    Volmat, V.2    Lenormand, P.3
  • 61
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • M. Raman W. Chen M.H. Cobb Differential regulation and properties of MAPKs Oncogene 26 2007 3100 3112
    • (2007) Oncogene , vol.26 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 62
    • 0034143365 scopus 로고    scopus 로고
    • ERKI/II regulation by the muscarinic acetylcholine receptors in neurons
    • K. Rosenblum M. Futter M. Jones E.C. Hulme T.V. Bliss ERKI/II regulation by the muscarinic acetylcholine receptors in neurons J Neurosci 20 2000 977 985
    • (2000) J Neurosci , vol.20 , pp. 977-985
    • Rosenblum, K.1    Futter, M.2    Jones, M.3    Hulme, E.C.4    Bliss, T.V.5
  • 63
    • 0034534995 scopus 로고    scopus 로고
    • Interleukin 1 in the brain: biology, pathology and therapeutic target
    • N.J. Rothwell G.N. Luheshi Interleukin 1 in the brain: biology, pathology and therapeutic target Trends Neurosci 23 2000 618 625
    • (2000) Trends Neurosci , vol.23 , pp. 618-625
    • Rothwell, N.J.1    Luheshi, G.N.2
  • 64
    • 0031040861 scopus 로고    scopus 로고
    • Cognitive functions of cortical acetylcholine: toward a unifying hypothesis
    • M. Sarter J.P. Bruno Cognitive functions of cortical acetylcholine: toward a unifying hypothesis Brain Res Brain Res Rev 23 1997 28 46
    • (1997) Brain Res Brain Res Rev , vol.23 , pp. 28-46
    • Sarter, M.1    Bruno, J.P.2
  • 65
    • 0036580703 scopus 로고    scopus 로고
    • Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition
    • M.J. Savage Y.G. Lin J.R. Ciallella D.G. Flood R.W. Scott Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition J Neurosci 22 2002 3376 3385
    • (2002) J Neurosci , vol.22 , pp. 3376-3385
    • Savage, M.J.1    Lin, Y.G.2    Ciallella, J.R.3    Flood, D.G.4    Scott, R.W.5
  • 66
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • R. Seger E.G. Krebs The MAPK signaling cascade FASEB J 9 1995 726 735
    • (1995) FASEB J , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 68
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • D.J. Selkoe Translating cell biology into therapeutic advances in Alzheimer's disease Nature 399 1999 A23 A31
    • (1999) Nature , vol.399 , pp. A23-A31
    • Selkoe, D.J.1
  • 69
  • 70
    • 0141672049 scopus 로고    scopus 로고
    • P38 MAP kinase is activated at early stages in Alzheimer's disease brain
    • A. Sun M. Liu X.V. Nguyen G. Bing P38 MAP kinase is activated at early stages in Alzheimer's disease brain Exp Neurol 183 2003 394 405
    • (2003) Exp Neurol , vol.183 , pp. 394-405
    • Sun, A.1    Liu, M.2    Nguyen, X.V.3    Bing, G.4
  • 71
    • 2942589223 scopus 로고    scopus 로고
    • Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain
    • J.E. Swatton L.A. Sellers R.L. Faull A. Holland S. Iritani S. Bahn Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain Eur J Neurosci 19 2004 2711 2719
    • (2004) Eur J Neurosci , vol.19 , pp. 2711-2719
    • Swatton, J.E.1    Sellers, L.A.2    Faull, R.L.3    Holland, A.4    Iritani, S.5    Bahn, S.6
  • 72
    • 0035166616 scopus 로고    scopus 로고
    • The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory
    • J.D. Sweatt The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory J Neurochem 76 2001 1 10
    • (2001) J Neurochem , vol.76 , pp. 1-10
    • Sweatt, J.D.1
  • 73
    • 2942550646 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in synaptic plasticity and memory
    • J.D. Sweatt Mitogen-activated protein kinases in synaptic plasticity and memory Curr Opin Neurobiol 14 2004 311 317
    • (2004) Curr Opin Neurobiol , vol.14 , pp. 311-317
    • Sweatt, J.D.1
  • 74
    • 0036840971 scopus 로고    scopus 로고
    • Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system
    • K. Takeda H. Ichijo Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system Genes Cells 7 2002 1099 1111
    • (2002) Genes Cells , vol.7 , pp. 1099-1111
    • Takeda, K.1    Ichijo, H.2
  • 75
    • 0026486878 scopus 로고
    • Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells: Comparison of the effects of nerve growth factor and epidermal growth factor
    • S. Traverse N. Gomez H. Paterson C. Marshall P. Cohen Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells Comparison of the effects of nerve growth factor and epidermal growth factor Biochem J 288 Pt 2 1992 351 355
    • (1992) Biochem J , vol.288 , Issue.Pt 2 , pp. 351-355
    • Traverse, S.1    Gomez, N.2    Paterson, H.3    Marshall, C.4    Cohen, P.5
  • 77
    • 0034119571 scopus 로고    scopus 로고
    • Time-dependent impairment of inhibitory avoidance retention in rats by posttraining infusion of a mitogen-activated protein kinase kinase inhibitor into cortical and limbic structures
    • R. Walz R. Roesler J. Quevedo M.K. Sant'Anna M. Madruga C. Rodrigues C. Gottfried J.H. Medina I. Izquierdo Time-dependent impairment of inhibitory avoidance retention in rats by posttraining infusion of a mitogen-activated protein kinase kinase inhibitor into cortical and limbic structures Neurobiol Learn Mem 73 2000 11 20
    • (2000) Neurobiol Learn Mem , vol.73 , pp. 11-20
    • Walz, R.1    Roesler, R.2    Quevedo, J.3    Sant'Anna, M.K.4    Madruga, M.5    Rodrigues, C.6    Gottfried, C.7    Medina, J.H.8    Izquierdo, I.9
  • 80
    • 0038400952 scopus 로고    scopus 로고
    • C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis
    • S. Willaime-Morawek K. Brami-Cherrier J. Mariani J. Caboche B. Brugg C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis Neuroscience 119 2003 387 397
    • (2003) Neuroscience , vol.119 , pp. 387-397
    • Willaime-Morawek, S.1    Brami-Cherrier, K.2    Mariani, J.3    Caboche, J.4    Brugg, B.5
  • 83
    • 0034797352 scopus 로고    scopus 로고
    • Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the “two hit” hypothesis
    • X. Zhu R.J. Castellani A. Takeda A. Nunomura C.S. Atwood G. Perry M.A. Smith Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the “two hit” hypothesis Mech Ageing Dev 123 2001 39 46
    • (2001) Mech Ageing Dev , vol.123 , pp. 39-46
    • Zhu, X.1    Castellani, R.J.2    Takeda, A.3    Nunomura, A.4    Atwood, C.S.5    Perry, G.6    Smith, M.A.7
  • 84
    • 0035142804 scopus 로고    scopus 로고
    • Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease
    • X. Zhu A.K. Raina C.A. Rottkamp G. Aliev G. Perry H. Boux M.A. Smith Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease J Neurochem 76 2001 435 441
    • (2001) J Neurochem , vol.76 , pp. 435-441
    • Zhu, X.1    Raina, A.K.2    Rottkamp, C.A.3    Aliev, G.4    Perry, G.5    Boux, H.6    Smith, M.A.7
  • 85
    • 0033782845 scopus 로고    scopus 로고
    • Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease
    • X. Zhu C.A. Rottkamp H. Boux A. Takeda G. Perry M.A. Smith Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease J Neuropathol Exp Neurol 59 2000 880 888
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 880-888
    • Zhu, X.1    Rottkamp, C.A.2    Boux, H.3    Takeda, A.4    Perry, G.5    Smith, M.A.6


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