Inhibition of lipopolysaccharide-induced I-κB degradation and tumor necrosis factor-α expression by dimethyl-4,4'-dimethoxy-5,6,5',6'- dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB): Minor role in hepatic detoxifying enzyme expression

Liver

Volumn 20, Issue 4, 2000, Pages 319-329

  Kim, Sang Geon ^a   Kim, Hye Jung ^a   Choi, Sung Hee ^a   Ryu, Ji Yeun ^a  

^a Seoul National University   (South Korea)

Author keywords

DDB; Dimethyl dioxybiphenyl dicarboxylate; Epoxide hydrolase; Glutathione S transferase; Nuclear factor B; Tumor necrosis factor cytochrome P450 2B

Indexed keywords

CYTOCHROME P450; DICARBOXYLIC ACID DERIVATIVE; DIMETHYL 4,4' DIMETHOXY 5,6,5',6' DIMETHYLENE DIOXYBIPHENYL 2,2' DICARBOXYLIC ACID; DIMETHYLNITROSAMINE DEMETHYLASE; ENDOTOXIN; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NUCLEAR FACTOR I; PHENACETIN O DEETHYLASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; IMMUNOBLOTTING; INFLAMMATION; LIVER MICROSOME; LIVER PROTECTION; MACROPHAGE; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS HEPATITIS; XENOBIOTIC METABOLISM;

ANIMALS; BIPHENYL COMPOUNDS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; CYTOCHROME P-450 CYP2B1; DIOXOLES; DNA PRIMERS; DRUGS, CHINESE HERBAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPOXIDE HYDROLASES; GLUTATHIONE TRANSFERASE; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICROSOMES, LIVER; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033943204     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0676.2000.020004319.x     Document Type: Article

References (42)

1. Specific evidence that schizandrins induce a phenobarbital-like cytochrome P450 form separated from rat liver
2. Pharmacological properties of dibenz(a,-o) cyclooctene derivatives isolated from Fructus schizandrae chinencis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachlor
3. A comparison of the protective actions of biphenyl dimethyl- dicarboxylate, trans-stilbene alcoholic extracts of Fructus schizandrae and ganoderma against experimental liver injury in mice
4. Further studies on the protective action of diphenyl dimethyl- dicarboxylate (DDB) against experimental liver injury in mice
5. Enhanced effectiveness of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in combination with garlic oil against experimental hepatic injury in rats and mice
6. Enhancing effects of dephenyl dimethyl dicarboxylate on serum antibody production in Balb/c mice
7. Prospective randomized controlled trial with diphenyldemethyldicarboxylate in chronic active liver disease: The effect on lowering serum alanine aminotransferase levels
8. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides
9. Differential regulation of lipopolysacchrides (LPS) activation pathways in mouse macrophages by LPS-binding proteins
10. The hepatitis B virus large surface protein is a transcriptional activator
11. Hepatitis B virus HBx protein activates transcription factor NF-kappa B by acting on multiple cytoplasmic inhibitors of rel-related proteins
12. Effects of cytokines on the liver
13. Molecular mechanism for alkyl sulfide-modulated carbon tetrachloride- induced hepatotxicity: the role of cytochrome P450 2E1, 2B and glutathione S-transferase expression
14. Protein measurement with the folin phenol reagent
15. Cleavage of structural proteins during assembly of the head of the bacteriophage T4
16. Transcriptional regulation of rat microsomal epoxide hydrolase gene by antimycotic agents
17. Expression of glutathione S-transferases Ya, Ybl, Yb2, Yc1 and Yc2 and microsomal epoxide hydrolase gene by thiazole, benzothiazole and benzothiadiazole
18. Enhancement of radiation-inducible hepatic glutathione S-transferase Ya, Yb1 Yb2, Yc1, and Yc2 expression by oltipraz: Possible role in radioprotection
19. Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction
20. An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
21. Cytochrome P450 2E1-and cytochrome P450 2B1/2B2-catalyzed carbon tetrachloride metabolism
22. Constitutive synthesis of protein 1 transcription factor after viral transformation of mouse fibroblasts
23. Inhibition of hepatocarcinogenic responses to 1,2-dimethylhydrazine by diallyl sulfide, a component of garlic oil
24. Mechanism of protection against aflatoxin tumorigenicity in rats fed 5- (2-pyraziny)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2- dithiol-3-thiones and 1,2-dithiol-3-ones
25. Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities
26. Modulation of rat hepatic microsomal monooxygenase enzymes and cytotoxicity by diallyl sulfide
27. Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (2E1) in rat and rabbit liver microsomes
28. Factors affecting the expression of triflouroacetylated liver microsomal protein neoantigens in rats treated with halothane
29. Lipopolysaccharide inhibition of rat hepatic microsomal epoxide hydrolase and glutathione S-transferase gene expression irrespective of nuclear factor-κB activation
30. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1
31. Antioxidants differentially affect nuclear factor κB-mediated nitric oxide synthase expression in vascular smooth muscle cells
32. Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells
33. Modulation of trancription factor NF-κB binding activity by oxidation- reduction in vitro
34. Hepatitis B virus pX activates NF-κB dependent transcription through a rafindependent pathway
35. The role of Rel/NF-κB proteins in viral oncogenesis and the regulation of viral transcription
36. 4- induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding
37. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation
38. Activation of the IκBα kinase complex by MEKKI, a kinase of the JNK pathway
39. Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl N- tert-butylnitrone (PBN)
40. Lipopolysaccharide potentiates the effect of hepatocyte growth factor on hepatocyte replication in rats by augmenting AP-1 activity
41. Calcium dependence of toxic cell death: A final common pathway
42. The effect of DDB on dystrophic hamsters: An in vivo and in vitro study