An estrogen receptor-β agonist is active in models of inflammatory and chemical-induced pain

European Journal of Pharmacology

Volumn 553, Issue 1-3, 2006, Pages 146-148

  Leventhal, Liza ^a   Brandt, Michael R ^a   Cummons, Terri A ^a   Piesla, Michael J ^a   Rogers, Kathryn E ^a   Harris, Heather A ^a  

^a PFIZER INC   (United States)

Author keywords

Estrogen receptor beta; Inflammation; Pain

Indexed keywords

2 (3 FLUORO 4 HYDROXYPHENYL) 7 VINYL 1,3 BENZOXAZOL 5 OL; 2 (3 FLUORO 4 HYDROXYPHENYL) 7 VINYL 5 BENZOXAZOLOL; BENZOXAZOLE DERIVATIVE; ESTROGEN RECEPTOR BETA AGONIST; HORMONE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; EXPERIMENTAL MODEL; HYPERALGESIA; INFLAMMATION; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN RECEPTOR BETA; HEAT; HYPERALGESIA; INFLAMMATION; MALE; OXAZOLES; PAIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33751190737     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.09.033     Document Type: Article

References (8)

1. Brandt M.R., Cummons T.A., Potestio L., Sukoff S.J., and Rosenzweig-Lipson S. Effects of the N-Methyl-d-aspartate Receptor antagonist perzinfotel [EAA-090; [2-(8,9-Dioxo-2,6-diazabicyclo[5.2.0 non-1(7)-en-2-yl)-ethyl]phosphonic Acid] on chemically induced thermal hypersensitivity. J. Pharmacol. Exp. Ther. 313 (2005) 1379-1386
2. Follettie M.T., Pinard M., Keith J.C., Wang L., Chelsky D., Hayward C., Kearney P., Thibault P., Paramithiotis E., Dorner A.J., and Harris H.A. Organ mRNA and plasma proteome changes in the adjuvant-induced arthritis model: responses to disease induction and therapy with the estrogen receptor-β selective agonist ERB-041. Endocrinology 147 (2006) 714-723
3. Greene G.L., Gilna P., Waterfield M., Baker A., Hort Y., and Shine J. Sequence and expression of human estrogen receptor complementary DNA. Science 231 (1986) 1150-1154
4. Harris, H.A., 2006. Estrogen receptor-β: Recent lessons from in vivo studies. Mol. Endocrinol. published March 23, 2006 as doi: 10.1210/me.2005-0459.
5. Harris H.A., Albert L.M., Leathurby Y., Malamas M.S., Mewshaw R.E., Miller C.P., Kharode Y.P., Marzolf J., Komm B.S., Winneker R.C., Frail D.E., Henderson R.A., Zhu Y., and Keith Jr. J.C. Evaluation of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 144 (2003) 4241-4249
6. Harris H.A., Bruner-Tran K.L., Zhang X., Osteen K.G., and Lyttle C.R. A selective estrogen receptor-β agonist causes lesion regression in an experimentally induced model of endometriosis. Hum. Reprod. 20 (2005) 936-941
7. Kuiper G.G.J.M., Enmark E., Pelto Huikko M., Nilsson S., and Gustafsson J.A. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 5925-5930
8. Whiteside G.T., Boulet J.M., and Walker K. The role of central and peripheral mu opioid receptors in inflammatory pain and edema: a study using morphine and DiPOA. J. Pharmacol. Exp. Ther. 314 (2005) 1234-1240