Clinical, HLA, and small bowel immunohistochemical features of children with positive serum antiendomysium antibodies and architecturally normal small intestinal mucosa

American Journal of Gastroenterology

Volumn 100, Issue 10, 2005, Pages 2294-2298

  Paparo, Francesco ^a   Petrone, Emma ^a   Tosco, Antonella ^a   Maglio, Maria ^a   Borrelli, Melissa ^a   Salvati, Virginia M ^a   Miele, Erasmo ^a   Greco, Luigi ^a   Auricchio, Salvatore ^a   Troncone, Riccardo ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Department of Pediatrics ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; ENDOMYSIUM ANTIBODY; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2 RECEPTOR ALPHA; AUTOANTIBODY; GUANINE NUCLEOTIDE BINDING PROTEIN; HLA ANTIGEN; IMMUNOGLOBULIN A; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TRANSGLUTAMINASE 2;

ADOLESCENT; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; CELIAC DISEASE; CELL DENSITY; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIETARY INTAKE; FEMALE; GLUTEN FREE DIET; HAPLOTYPE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOGENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; INTESTINE VILLUS ATROPHY; JEJUNUM BIOPSY; LAMINA PROPRIA; LYMPHOCYTIC INFILTRATION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; SMALL INTESTINE; BLOOD; CASE CONTROL STUDY; CONNECTIVE TISSUE; FOLLOW UP; GENETICS; IMMUNOLOGY; INFANT; INTESTINE MUCOSA; JEJUNUM; METABOLISM; PRESCHOOL CHILD;

ADOLESCENT; AUTOANTIBODIES; CASE-CONTROL STUDIES; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; CONNECTIVE TISSUE; FEMALE; FOLLOW-UP STUDIES; GTP-BINDING PROTEINS; HLA ANTIGENS; HUMANS; IMMUNOGLOBULIN A; INFANT; INTESTINAL MUCOSA; JEJUNUM; MALE; TRANSGLUTAMINASES;

EID: 27744494077     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2005.41134.x     Document Type: Article

References (19)

1. Green PH Jabri B. Coeliac disease. Lancet 2003 362 : 383 91.
2. Walker-Smith JA Guandalini S Schmitz J, et al. Revised criteria for the diagnosis of celiac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 1990 65 : 909 11.
3. Chorzelski TP Beutner EH Sulej J, et al. IgA anti-endomysium antibody. A new immunological marker of dermatitis herpetiformis and coeliac disease. Br J Dermatol 1984 111 : 395 402.
4. Ladinser B Rossipal E Pittschieler K. Endomysium antibodies in coeliac disease: An improved method. Gut 1994 35 : 776 8.
5. Sulkanen S Halttunen T Laurila K, et al. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology 1998 115 : 1322 8.
6. Troncone R Maurano F Rossi M, et al. IgA antibodies to tissue transglutaminase: An effective diagnostic test for celiac disease. J Pediatr 1999 134 : 166 71.
7. Maki M Holm K Lipsanen V, et al. Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease. Lancet 1991 338 : 1350 3.
8. Oberhuber G Granditsch G Vogelsang H. The histopathology of celiac disease: Time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999 11 : 1185 94.
9. Marsh MN. Studies of intestinal lymphoid tissue XIII. Immunopathology of the evolving celiac sprue lesion. Pathol Res Pract 1989 185 : 774 7.
10. Holm K Maki M Savilahti E, et al. Intraepithelial gamma delta T-cell-receptor lymphocytes and genetic susceptibility to coeliac disease. Lancet 1992 339 : 1500 3.
11. Maki M Holm K Collin P, et al. Increase in gamma/delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease. Gut 1991 32 : 1412 4.
12. Iltanen S Holm K Ashorn M, et al. Changing jejunal gamma delta T cell receptor (TCR)-bearing intraepithelial lymphocyte density in coeliac disease. Clin Exp Immunol 1999 117 : 51 5.
13. Holm K Savilahti E Koskimies S, et al. Immunohistochemical changes in the jejunum in first degree relatives of patients with coeliac disease and the coeliac disease marker DQ genes. HLA class II antigen expression, interleukin-2 receptor positive cells and dividing crypt cells. Gut 1994 35 : 55 60.
14. Westerholm-Ormio M Garioch J Ketola I, et al. Inflammatory cytokines in small intestinal mucosa of patients with potential coeliac disease. Clin Exp Immunol 2002 128 : 94 101.
15. Maiuri L Ciacci C Raia V, et al. FAS engagement drives apoptosis of enterocytes of coeliac patients. Gut 2001 48 : 418 24.
16. Picarelli A Maiuri L Frate A, et al. Production of antiendomysial antibodies after in-vitro gliadin challenge of small intestine biopsy samples from patients with coeliac disease. Lancet 1996 348 : 1065 7.
17. Marzari R Sblattero D Florian F, et al. Molecular dissection of the tissue transglutaminase autoantibody response in celiac disease. J Immunol 2001 166 : 4170 6.
18. Collin P Helin H Maki M, et al. Follow-up of patients positive in reticulin and gliadin antibody tests with normal small bowel biopsy findings. Scand J Gastroenterol 1993 23 : 595 8.
19. Kaukinen K Maki M Partanen J, et al. Celiac disease without villous atrophy: Revision of criteria called for. Dig Dis Sci 2001 46 : 879 87.