Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition

Epilepsy Research

Volumn 79, Issue 2-3, 2008, Pages 105-111

  Thöne, Jan ^a   Leniger, Tobias ^a   Splettstösser, Frank ^a   Wiemann, Martin ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

4 Aminopyridine; Carbonic anhydrase; Intracellular pH; Theophylline; Zonisamide

Indexed keywords

4 AMINOPYRIDINE; AMMONIA; BICARBONATE; BUFFER; CARBONATE DEHYDRATASE; FLUORESCEIN DERIVATIVE; THEOPHYLLINE; ZONISAMIDE;

ACIDOSIS; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN NERVE CELL; BRAIN SLICE; BRAIN TISSUE; CELL MEMBRANE POTENTIAL; CELL PH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; EPILEPSY; EPILEPTIC DISCHARGE; EXPERIMENTAL MODEL; FEMALE; GUINEA PIG; HIPPOCAMPUS; HYPERCAPNIA; IN VITRO STUDY; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STEADY STATE;

4-AMINOPYRIDINE; ANIMALS; ANTICONVULSANTS; CARBONIC ANHYDRASE INHIBITORS; DATA INTERPRETATION, STATISTICAL; ELECTROPHYSIOLOGY; EPILEPSY; FEMALE; GUINEA PIGS; HIPPOCAMPUS; HYDROGEN-ION CONCENTRATION; ISOXAZOLES; MEMBRANE POTENTIALS; MICROELECTRODES; NEURONS; PHOSPHODIESTERASE INHIBITORS; POTASSIUM CHANNEL BLOCKERS; THEOPHYLLINE;

EID: 42749087849     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2007.11.009     Document Type: Article

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