Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures

Molecular Brain Research

Volumn 116, Issue 1-2, 2003, Pages 1-6

  Ueda, Yuto ^a   Doi, Taku ^a   Tokumaru, Jun ^a   Willmore, L James ^b  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epilepsy; GABA; Glutamate; Transporter; Western blot; Zonisamide

Indexed keywords

4 AMINOBUTYRIC ACID; EXCITATORY AMINO ACID; FERRIC CHLORIDE; GLUTAMIC ACID; SODIUM CHLORIDE; ZONISAMIDE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CHRONIC DISEASE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; EPILEPTOGENESIS; FRONTAL CORTEX; HIPPOCAMPUS; INJECTION; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RAT; RECURRENT DISEASE; REGULATORY MECHANISM; SEIZURE; WESTERN BLOTTING;

ANIMALIA;

EID: 0042520948     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(03)00183-9     Document Type: Article

References (37)

1. Braestrup C., Nielsen E.B., Sonnewald U., Knutsen L.J., Andersen K.E., Jansen J.A., Frederiksen K., Andersen P.H., Mortensen A., Suzdak P.D. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J. Neurochem. 54:1990;639-647.
2. Danbolt N.C., Pines G., Kanner B.I. Purification and reconstitution of the sodium- and potassium-coupled glutamate transport glycoprotein from rat brain. Biochemistry. 29:1990;6734-6740.
3. During M.J., Ryder K.M., Spencer D.D. Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature. 376:1995;174-177.
4. Hassel B., Iversen E.G., Gjerstad L., Tauboll E. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. J. Neurochem. 77:2001;1285-1292.
5. Ikegaki N., Saito N., Hashima M., Tanaka C. Production of specific antibodies against GABA transporter subtypes (GAT1, GAT2, GAT3) and their application to immunocytochemistry. Mol. Brain Res. 26:1994;47-54.
6. Ito T., Hori M., Kadokawa T. Effects of zonisamide (AD-810) on tungstic acid gel-induced thalamic generalized seizures and conjugated estrogen-induced cortical spike-wave discharges in cats. Epilepsia. 27:1986;367-374.
7. Kanai Y. Family of neural and acidic amino acid transporters: molecular biology, physiology and medical implications. Curr. Opin. Cell Biol. 9:1997;565-572.
8. Kanai Y., Hediger M.A. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature. 360:1992;467-471.
9. Kitani K., Sato Y., Kanai S., Nokubo M., Ohta M., Masuda Y. Increasing anticonvulsant effect of AD-810 (zonisamide) in aging BDF1 mice. Life Sci. 41:1987;1339-1344.
10. Kito M., Maehara M., Watanabe K. Mechanisms of T-type calcium channel blockade by zonisamide. Seizure. 5:1996;115-119.
11. Komatsu M., Okamura Y., Hiramatsu M. Free radical scavenging activity of zonisamide and its inhibitory effect on lipid peroxide formation in iron-induced epileptogenic foci of rats. Neurosciences. 21:1995;23-29.
12. Leppik I.E., Willmore L.J., Homan R.W., Fromm G., Oommen K.J., Penry J.K., Sackellares J.C., Smith D.B., Lesser R.P., Wallace J.D., et al. Efficacy and safety of zonisamide: results of a multicenter study. Epilepsy Res. 14:1993;165-173.
13. Liu Q.R., Mandiyan S., Nelson H., Nelson N. A family of genes encoding neurotransmitter transporters. Proc. Natl. Acad. Sci. USA. 89:1992;6639-6643.
14. Lothman E.W., Bennett J.P., Perlin J.B. Alterations in neurotransmitter amino acids in hippocampal kindled seizures. Epilepsy Res. 1:1987;313-320.
15. Macdonald R.L., Kelly K.M. Antiepileptic drug mechanisms of action. Epilepsia. 34:1993;S1-8.
16. Mori A., Noda Y., Packer L. The anticonvulsant zonisamide scavenges free radicals. Epilepsy Res. 30:1998;153-158.
17. Okada M., Kaneko S., Hirano T., Ishida M., Kondo T., Otani K., Fukushima Y. Effects of zonisamide on extracellular levels of monoamine and its metabolite, and on Ca2+ dependent dopamine release. Epilepsy Res. 13:1992;113-119.
18. Okada M., Kaneko S., Hirano T., Mizuno K., Kondo T., Otani K., Fukushima Y. Effects of zonisamide on dopaminergic system. Epilepsy Res. 22:1995;193-205.
19. Okada M., Kawata Y., Mizuno K., Wada K., Kondo T., Kaneko S. Interaction between Ca2+, K+, carbamazepine and zonisamide on hippocampal extracellular glutamate monitored with a microdialysis electrode. Br. J. Pharmacol. 124:1998;1277-1285.
20. Oommen K.J., Mathews S. Zonisamide: a new antiepileptic drug. Clin. Neuropharmacol. 22:1999;192-200.
21. Pines G., Danbolt N.C., Bjoras M., Zhang Y., Bendahan A., Eide L., Koepsell H., Storm Mathisen J., Seeberg E., Kanner B.I. Cloning and expression of a rat brain L-glutamate transporter. Nature. 360:1992;464-467.
22. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32:1972;281-294.
23. Rock D.M., Macdonald R.L., Taylor C.P. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant. Epilepsy Res. 3:1989;138-143.
24. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J.P., Welty D.F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686.
25. Sackellares J.C., Donofrio P.D., Wagner J.G., Abou-Khalil B., Berent S., Aasved-Hoyt K. Pilot study of zonisamide (1,2-benzisoxazole-3-methanesulfonamide) in patients with refractory partial seizures. Epilepsia. 26:1985;206-211.
26. Schagger H., von Jagow G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:1987;368-379.
27. Schauf C.L. Zonisamide enhances slow sodium inactivation in Myxicola. Brain Res. 413:1987;185-188.
28. Sepkuty J.P., Cohen A.S., Eccles C., Rafiq A., Behar K., Ganel R., Coulter D.A., Rothstein J.D. A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. J. Neurosci. 22:2002;6372-6379.
29. Storck T., Schulte S., Hofmann K., Stoffel W. Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. Proc. Natl. Acad. Sci. USA. 89:1992;10955-10959.
30. Suzdak P.D., Jansen J.A. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia. 36:1995;612-626.
31. Suzuki S., Kawakami K., Nishimura S., Watanabe Y., Yagi K., Seino M., Miyamoto K. Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex. Epilepsy Res. 12:1992;21-27.
32. Tokumaru J., Ueda Y., Yokoyama H., Nakajima A., Doi T., Mitsuyama Y., Ohya-Nishiguchi H., Kamada H. In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats. Neurochem. Res. 25:2000;1107-1111.
33. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
34. Ueda Y., Doi T., Tokumaru J., Yokoyama H., Nakajima A., Mitsuyama Y., Ohya-Nishiguchi H., Kamada H., Willmore L.J. Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid. J. Neurochem. 76:2001;892-900.
35. Ueda Y., Tsuru N. Simultaneous monitoring of the seizure-related changes in extracellular glutamate and gamma-aminobutyric acid concentration in bilateral hippocampi following development of amygdaloid kindling. Epilepsy Res. 20:1995;213-219.
36. Ueda Y., Willmore L.J. Hippocampal gamma-aminobutyric acid transporter alterations following focal epileptogenesis induced in rat amygdala [In Process Citation]. Brain Res. Bull. 52:2000;357-361.
37. Ueda Y., Willmore L.J., Triggs W.J. Amygdalar injection of FeCl3 causes spontaneous recurrent seizures. Exp. Neurol. 153:1998;123-127.