Zonisamide improves motor function in Parkinson disease: A randomized, double-blind study

Neurology

Volumn 68, Issue 1, 2007, Pages 45-50

  Murata, Miho ^a   Hasegawa, Kazuko ^b   Kanazawa, Ichiro ^a   Aizawa, H ^c   Kimura, T ^d   Kikuchi, S ^e   Baba, M ^f   Chida, K ^g   Hisanaga, K ^h   Toyoshima, I ⁱ   Kurita, K ^j   Suzuki, Y ^k   Yoshizawa, K ^l   Shoji, S ^m   Nakano, I ⁿ   Hirata, K ^o   Kamakura, K ^p   Shimizu, T ^q   Nogawa, S ^r   Utsumi, H ^s   Mizusawa, H ^t   Yokochi, F ^u   Hirabayashi, K ^v   Hasegawa, K ^b   Takahashi, Y ^w   Kuroiwa, Y ^x   Kameyama, S ^y   Komai, K ^z   Hashimoto, T ^aa   Mizoguchi, K ^ab   Mitake, S ^ac   Yasuda, T ^ad   Washimi, Y ^ae   Tatsuoka, Y ^af   Matsumoto, S ^ag   Abe, K ^ah   Fujimura, H ^ai   Hashiguchi, H ^aj   Nakashima, K ^ak   Takamatsu, K ^al   Yamada, T ^am,ap   Nomoto, M ^an   Yuhi, T ^ao   Ikezoe, K ^aq   Sato, A ^ar   Matsuo, H ^as   Tsuruta, K ^at   Arimura, K ^au   Yuasa, T ^av   Kawashima, N ^aw   Ishikawa, A ^ax   Yoshikawa, N ^ay   Higashi, Y ^az   Ohnishi, H ^ba   Yoshinaga, J ^bb   Fujita, H ^bc   Katagi, R ^bd   Miyajima, H ^be   Ojika, K ^bf   Kawamura, M ^bg   more..

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^b SAGAMIHARA NATIONAL HOSPITAL   (Japan)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

^d Department of Respiratory Medicine   (Japan)

^e HOKKAIDO UNIVERSITY   (Japan)

^f HIROSAKI UNIVERSITY   (Japan)

^g National Hospital Organization Iwate Hospital   (Japan)

^h MIYAGI NATIONAL HOSPITAL   (Japan)

ⁱ AKITA UNIVERSITY   (Japan)

^j YAMAGATA UNIVERSITY   (Japan)

^k Nihonkai General Hospital   (Japan)

^l NATIONAL HOSPITAL ORGANIZATION MITO MEDICAL CENTER   (Japan)

^m UNIVERSITY OF TSUKUBA   (Japan)

ⁿ JICHI MEDICAL UNIVERSITY   (Japan)

^o DOKKYO MEDICAL UNIVERSITY   (Japan)

^p NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^q TEIKYO UNIVERSITY   (Japan)

^r KEIO UNIVERSITY   (Japan)

^s TOKYO MEDICAL UNIVERSITY   (Japan)

^t TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^u TOKYO METROPOLITAN TAMA MEDICAL CENTER   (Japan)

^v Department of Dentistry Oral surgery   (Japan)

^w ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^x YOKOHAMA CITY UNIVERSITY   (Japan)

^y NISHI NIIGATA CHUO NATIONAL HOSPITAL   (Japan)

^z KANAZAWA UNIVERSITY   (Japan)

^aa SHINSHU UNIVERSITY   (Japan)

^ab SHIZUOKA INSTITUTE OF EPILEPSY AND NEUROLOGICAL DISORDERS   (Japan)

^ac TOSEI GENERAL HOSPITAL   (Japan)

^ad TOYOTA MEMORIAL HOSPITAL   (Japan)

^ae NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^af Tatsuoka Neurology Clinic   (Japan)

^ag Kitano Hospital   (Japan)

^ah OSAKA UNIVERSITY   (Japan)

^ai TONEYAMA NATIONAL HOSPITAL   (Japan)

^aj Nippon Steel Hirohata Hospital   (Japan)

^ak TOTTORI UNIVERSITY   (Japan)

^al Brain Attack Center   (Japan)

^am Yamada Neurosurgery Hospital   (Japan)

^an EHIME UNIVERSITY   (Japan)

^ao UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^ap FUKUOKA UNIVERSITY   (Japan)

^aq KYUSHU UNIVERSITY   (Japan)

^ar Nagasaki Kita Hospital   (Japan)

^as NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

^at Koga General Hospital   (Japan)

^au KAGOSHIMA UNIVERSITY   (Japan)

^av 1 7 1 Kohnodai   (Japan)

^aw Kawashima Neurology Clinic   (Japan)

^ax National Hospital Organization   (Japan)

^ay Yoshikawa Clinic   (Japan)

^az Himeji Central Hospital   (Japan)

^ba Ohnishi Neurosurgical Center   (Japan)

^bb HIROSHIMA CITY HOSPITAL   (Japan)

^bc Murakami Memorial Hospital   (Japan)

^bd Katagi Neurological Surgery   (Japan)

^be HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^bf NAGOYA CITY UNIVERSITY HOSPITAL   (Japan)

^bg SHOWA UNIVERSITY HOSPITAL   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; DOPA DECARBOXYLASE INHIBITOR; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; MONOAMINE OXIDASE B INHIBITOR; PLACEBO; THREO 3,4 DIHYDROXYPHENYLSERINE; ZONISAMIDE;

ADD ON THERAPY; ADULT; AGED; APATHY; APPETITE; BODY WEIGHT; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSKINESIA; FEMALE; HUMAN; INCIDENCE; JAPAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PARALLEL DESIGN; PARKINSON DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; REVIEW; SIDE EFFECT; SOMNOLENCE; TREATMENT DURATION; TREATMENT RESPONSE; UNIFIED PARKINSON DISEASE RATING SCALE;

EID: 33846054367     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000250236.75053.16     Document Type: Article

References (17)

1. Uno H, Kurokawa M, Masuda Y, Nishimura H. Studies on 3-substituted 1.2-benzisoxazole derivatives 6: syntheses of 3-(sulfamoylmethyl)-1,2- benzisoxazole derivatives and their anticonvulsant activities. J Med Chem 1979;22:180-183.
2. Murata M, Horiuchi E, Kanazawa I. Zonisamide has beneficial effects on Parkinson's disease patients. Neurosci Res 2001;41:397-399.
3. Murata M, Hasegawa K, Kanazawa I. Randomized, double-blind study of zonisamide with placebo in advanced Parkinson's disease. Mov Disord 2004;19: (suppl 9):S198.
4. Rascol O, Brooks D, Melamed E, et al. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomized, double-blind, parallel-group trial. Lancet 2005;365:947-954.
5. Morita S, Miwa H, Kondo T. Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol. Parkinsonism Relat Disord 2005;11:101-103.
6. Yoshida S, Okada M, Zhu G, Kaneko S. Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors. Epilepsy Res 2005;67:153-162.
7. Ueda Y, Doi T, Tokumaru J, Willmore LJ. Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures. Brain Res Mol Brain Res 2003;116:1-6.
8. Stocchi F, Vacca L, Ruggieri S, Olanow WC. Intermittent vs continuous levodopa administration in patients with advanced Parkinson disease. Arch Neurol 2005;62:905-910.
9. Mizuno Y, Yanagisawa N, Kuno S, et al. Randomized, double-blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease. Mov Disord 2003;18:1149-1156.
10. Schauf CL. Zonisamide enhances slow sodium inactivation in Myxicola. Brain Res 1987;413:185-188.
11. Rock DM, Macdonald RL, Taylor CP. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant. Epilepsy Res 1989;3:138-143.
12. Suzuki S, Kawakami K, Nishimura S, et al. Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex. Epilepsy Res 1992;12:21-27.
13. Kito M, Maehara M, Watanabe K. Mechanisms of T-type calcium channel blockade by zonisamide. Seizure 1996;5:115-119.
14. Murata M. Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease. Curr Pharm Des 2004;10:687-693.
15. Okada M, Kaneko S, Hirano T, et al. Effects of zonisamide on dopaminergic system. Epilepsy Res 1995;22:193-205.
16. Gluck MR, Santana LA, Granson H, Yahr MD. Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J Neural Transm 2004;111:713-724.
17. 2+ dependent dopamine release. Epilepsy Res 1992;13:113-119.