Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and Aβ production in cortical neurons

Neurobiology of Disease

Volumn 30, Issue 2, 2008, Pages 243-254

  Gavín, Rosalina ^a,b,e   Ureña, Jesus ^b,e   Rangel, Alejandra ^a,b,e   Pastrana, Miguel A ^c   Requena, Jesús R ^c   Soriano, Eduardo ^b,e   Aguzzi, Adriano ^d   Del Río, José A ^a,b,e  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

Amyloidoses; Intracellular kinases; Mouse disabled 1; Neuropathology; Oxidative stress; Prion

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ACETYLCYSTEINE; ADAPTOR PROTEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DAB1 PROTEIN; DIPHENYLIODONIUM SALT; FIBRILLAR PRION PEPTIDE; HERBIMYCIN A; PRION PROTEIN; PROTEIN TYROSINE KINASE; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CELL MEMBRANE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; HAMSTER; HUMAN; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; CRICETINAE; FEMALE; HUMANS; MESOCRICETUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; NERVE TISSUE PROTEINS; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PREGNANCY; PRIONS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PRP 27-30 PROTEIN;

EID: 42649101642     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.02.001     Document Type: Article

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