Identification of Haemophilus ducreyi genes expressed during human infection

Microbiology

Volumn 154, Issue 4, 2008, Pages 1152-1160

  Bauer, Margaret E ^a   Fortney, Kate R ^a   Harrison, Alistair ^b   Janowicz, Diane M ^a   Munson Jr , Robert S ^b,c   Spinola, Stanley M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL RNA; COMPLEMENTARY DNA; PROTEIN ISPA1; PROTEIN ISPA2; PROTEIN TADA;

ARTICLE; BACTERIAL VIRULENCE; BIOSYNTHESIS; CASE REPORT; CELL DIVISION; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GRAM NEGATIVE INFECTION; HAEMOPHILUS DUCREYI; HUMAN; HUMAN TISSUE; IN VIVO STUDY; METABOLISM; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL; PUSTULE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; RNA TRANSLATION; SOUTHERN BLOTTING; STRESS; VOLUNTEER;

FEMALE; GENE EXPRESSION PROFILING; GENES, BACTERIAL; HAEMOPHILUS DUCREYI; HUMAN EXPERIMENTATION; HUMANS; MALE; SKIN DISEASES, BACTERIAL;

BACTERIA (MICROORGANISMS); HAEMOPHILUS DUCREYI;

EID: 42549166074     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2007/013953-0     Document Type: Article

References (55)

1. Al-Tawfiq, J. A., Thornton, A. C, Katz, B. P., Fortney, K. R., Todd, K. D., Hood, A. F. & Spinola, S. M. (1998). Standardization of the experimental model of Haemophilus ducreyi infection in human subjects. J Infect Dis 178, 1684-1687.
2. Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P. Elkins, C. & Spinola, S. M. (2000). An isogenic hemoglobin receptor-defident mutant of Haemophilus ducreyi is attenuated in the human model of experimental infection. J Infect Dis 181, 1049-1054.
3. Baltes, N. & Gerlach, G. F. (2004). Identification of genes transcribed by Actinobacillus pleuropneumoniae in necrotic porcine lung tissue by using selective capture of transcribed sequences. Infect Immun 72, 6711-6716.
4. Bauer, M. E. & Spinola, S. M. (2000). Localization of Haemophilus ducreyi at the pustular stage of disease in the human model of infection. Infect Immun 68, 2309-2314.
5. Bauer, M. E., Goheen, M. P., Townsend, C. A. & Spinola, S. M. (2001). Haemophilus ducreyi associates with phagocytes, collagen, and fibrin and remains extracellular throughout infection of human volunteers. Infect Immun 69, 2549-2557.
6. Bauer, M. E., Townsend, C. A., Ronald, A. R. & Spinola, S. M. (2006). Localization of Haemophilus ducreyi in naturally acquired chancroidal ulcers. Microbes Infect 8, 2465-2468.
7. Bong, C. T. H, Throm, R. E., Fortney, K. R., Katz, B. P., Hood, A. F., Elkins, C. & Spinola, S, M. (2001). DsrA-deficient mutant of Haemophilus ducreyi is impaired in its ability to infect human volunteers. Infect Immun 69, 1488-1491.
8. Bong, C. T. H., Bauer, M. E & Spinola, S. M. (2002a). Haemophilus ducreyi: clinical features, epidemiology, and prospects for disease control. Microbes Infect 4, 1141-1148.
9. Bong, C. T. H., Hareziak, J., Katz, B. P. & Spinola, S. M. (2002b). Men are more susceptible to pustule formation than women in the experimental model of Haemophilus ducreyi infection. Sex Transm Dis 29, 114-118.
10. Camilli, A. & Mekalanos, J. J. (1995). Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection. Mol Microbiol 18 671-683.
11. Cano, D. A, Pucciarelli, M. G., Garcia-del Portillo, F. & Casadesús, J. (2002). Role of the RecBCD recombination pathway in Salmonella virulence. J Bacteriol 184, 592-595.
12. Chiang, S. L., Mekalanos, J. J. & Holden, D. W. (1999). In vivo genetic analysis of bacterial virulence. Annu Rev Microbiol 53, 129-154.
13. Cunin, R, Glansdorff, N, Piérard, A. & Stalon, V. (1986). Biosynthesis and metabolism of arginine in bacteria. Microbiol Rev 50, 314-352.
14. Daigle, F., Graham, J. E. & Curtiss, R., III (2001). Identification of Salmonella typhi genes expressed within macropbages by selective capture of transcribed sequences (SCOTS). Mol Microbiol, 41, 1211-1222.
15. Daigle, F., Hou, J. Y. Clark-Curtiss, J. E. (2002). Microbial gene expression elucidated by selective capture of transcribed sequences (SCOTS). Methods Enzymol 358, 108-122.
16. Dozois, C. M., Daigle, F. & Curtiss, R., III (2003). Identification of pathogen-specific and conserved genes expressed in vivo by an avian pathogenic Escherichia coli strain. Proc Natl Acad Sci U S A 100, 247-252.
17. Faucher, S. P., Porwollik, S., Dozois, C. M., McClelland, M. & Daigle, F. (2006). Transcriptome of Salmonella enterica serovar Typhi within macrophages revealed through the selective capture of transcribed sequences. Proc Natl Acad Sci U S A 103, 1906-1911.
18. Fortney, K. R., Young, R. S., Bauer, M. E., Katz, B. P., Hood, A. F., Munson, R. S., Jr & Spinola, S. M. (2000). Expression of peptidoglycan-associated lipoprotein is required for virulence in the human model of Haemophilus ducreyi infection. Infect Immun 68, 6441-6448.
19. Froussard, P. (1992). A random-PCR method (rPCR) to construct whole cDNA library from low amounts of RNA. Nucleic Acids Res 20, 2900.
20. Fulcher, R. A., Cole, I. E., Janowicz, D. M., Toffer, K. L., Fortney, K. R., Katz, B. P., Orndorff, P. E., Spinola, S. M. & Kawula, T. H. (2006). Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid. Infect Immun 74, 2651-2658.
21. Gourse, R. L., Gaal, T., Bartlett M. S., Appleman, J. A. & Ross, W. (1996). rRNA transcription and growth rate-dependent regulation of ribosome synthesis in Escherichia coli. Annu Rev Microbiol 50, 645-677.
22. Graham, J. E. & Clark-Curtiss, J. E (1999). Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS). Proc Natl Acad Sci U S A 96, 11554-11559.
23. Graham, J. E., Peek, R. M., Jr, Krishna, U. & Cover, T. L (2002). Global analysis of Helicobacter pylori gene expression in human gastric mucosa. Gastroenterology 123, 1637-1648.
24. Grass, S., Buscher, A. Z., Swords, W. E., Apicella, M. A., Barenkamp, S. J, Ozchlewski N. & St. Geme, J. W, III (2003). The Haemophilus influenzae HMW1 adhesin is glycosylated in a process that requires HMW1C and phosphoglucomutase, an enzyme involved in lipooligosaccharide biosynthesis. Mol Microbiol 48, 737-751.
25. Haydel, S. E., Benjamin, W. H., Jr, Dunlap, N. E. & Clark-Curtiss, J. E. (2002). Expression, autoregulation, and DNA binding properties of the Mycobacterium tuberculosis TrcR response regulator. J Bacteriol 184, 2192-2203.
26. 2, pH, and redox potential of experimental abscesses. Proc Soc Exp Biol Med 147, 29-30.
27. Hou, J. Y., Graham, J. E. & Clark-Curtiss, J. E. (2002). Mycobacterium avium genes expressed during growth in human macrophages detected by selective capture of transcribed sequences (SCOTS). Infect Immun 70, 3714-3726.
28. Janowicz, D. M., Fortney, K. R., Katz, B. P., Latimer, J. L., Deng, K., Hansen, E. J. & Spinola, S. M. (2004). Expression of the LspA1 and LspA2 proteins by Haemophilus ducreyi is required for virulence in human volunteers. Infect Immun 72, 4528-4533.
29. Janowicz, D. M., Leduc, I., Fortney, K. R., Katz, B. P., Elkins, C. & Spinola, S. M. (2006a). A DltA mutant of Haemophilus ducreyi is partially attenuated in its ability to cause pustules in human volunteers. Infect Immun 74, 1394-1397.
30. Janowicz, D. M., Luke, N. R., Fortney, K. R., Katz, B. P., Campagnari, A. A. & Spinola, S. M. (2006b). Expression of OmpP2A and OmpP2B is not required for pustule formation by Haemophilus ducreyi in human volunteers. Micro Pathog 40, 110-115.
31. Jennings, M. P. & Beacham, I. R. (1990). Analysis of the Escherichia coli gene encoding L-asparaginase II, ansB, and its regulation by cyclic AMP receptor. J Bacteriol 172, 1491-1498.
32. Liu, S., Graham, J. E, Bigelow, L, Morse, P. D, II & Wilkinson, B. J. (2002). Identification of Listeria monocytogenes genes expressed in response to growth at low temperature. Appl Environ Microbiol 68, 1697-1705.
33. Mahan, M. J., Slauch, J. M. & Mekalanos, J. J. (1993). Selection of bacterial virulence genes that are specifically induced in host tissues. Science 259, 686-688.
34. Mahan, M. J., Heithoff, D. M, Sinshelmer, R. L. & Low, D. A. (2000). Assessment of bacterial pathogenesis by analysis of gene expression in the host. Annu Rev Genet 34, 139-164.
35. Morrow, B. J., Graham, J. E. & Curtiss, R., III (1999). Genomic subtractive hybridization and selective capture of transcribed sequences identify a novel Salmonella typhimurium fimbrial operon and putative transcriptional regulator that are absent from the Salmonella typhi genome. Infect Immun 67, 5106-5116.
36. Munson, R. S., Jr, Harrison, A., Gillaspy, A., Ray, W. C., Carson, M., Armbruster, D., Gipson, J., Gipson, M, Johnson, L & other authors (2004). Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates. Infect Immun 72, 3002-3010.
37. Nike, J. R., Latimer, J. L., Ward, C. K, Blick, R. J, Wagner, N. J., Cope, L. D., Mahairas, G. G., Munson, R. S., Jr & Hansen, E. J. (2002). Haemophilus ducreyi requires the flp gene cluster for microcolony formation in vitro. Infect Immun 70, 2965-2975.
38. Palmer, K. L., Schnizlein-Bick, C. T., Orazi, A., John, K., Chen, C.-Y., Hood, A. F. & Spinola, S. M. (1998). The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects. J Infect Dis 178, 1688-1697.
39. Post D. M., Mungur, R., Gibson, B. W. & Munson, R. S, Jr (2005). Identification of a novel sialic acid transporter in Haemophilus ducreyi. Infect Immun 73, 6727-6735.
40. Rediers, H., Rainey, P. B., Vanderleyden, J. & De Mot, R. (2005). Unraveling the secret lives of bacteria: use of in vivo expression technology and differential fluorescence induction promoter traps as tools for exploring niche-specific gene expression. Microbiol Mol Biol Rev 69, 217-261.
41. Sawars, G. & Bock, A. (1988). Anaerobic regulation of pyruvate formate-lyase from Escherichia coli K-12. J Bacteriol 170, 5330.
42. Shelburne, S. A. & Musser, J. M. (2004). Virulence gene expression in vivo. Curr Opin Microbiol 7, 283-289.
43. Spinola, S. M., Wild, L. M., Apicella, M. A., Gaspari, A. A. & Campagnari, A. A. (1994). Experimental human infection with Haemophilus ducreyi. J Infect Dis 169, 1146-1150.
44. Spinola, S. M, Orazi, A., Amo, J. N., Fortney, K, Kotylo, P., Chen, C.-Y., Campagnari, A. A. & Hood, A. F. (1996). Haemophilus ducreyi elicits a cutaneous infiltrate of CD4 cells during experimental human infection. J Infect Dis 173, 394-402.
45. Spinola, S. M, Bauer, M. E. & Munson, R. S., Jr (2002). Immunopathogenesis of Haemophilus ducreyi infection (chancroid). Infect Immun 70, 1667-1676.
46. Spinola, S. M., Bong, C. T. H., Faber, A. L., Fortney, K. R., Bennett, S. L., Townsend, C. A., Zwickl, B. E., Billings, S. D, Humphreys, T. L. & other authors (2003a). Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection. Infect Immun 71, 6658-6663.
47. Spinola, S. M., Fortney, K. R., Katz, B. P., Latimer, J. L., Mock, J. R., Vakevainen, M. & Hanson, E. J. (2003b). Haemophilus ducreyi requires an intact flp gene cluster for virulence in humans. Infect Immun 71, 7178-7182.
48. St. Geme, J. W., III & Grass, S. (1998). Secretion of the Haemophilus influenzae HMW1 and HMW2 adhesins involves a periplasmic intermediate and requires the HMWB and HMWC proteins. Mol Microbiol 27, 617-630.
49. Steen, R. (2001). On eradicating chancroid. Bull World Health Organ 79, 818-826.
50. Stevens, M. K., Latimer, J. L., Lumbley, S. R., Ward, C. K., Cope, L. D., Lagergård, T. & Hansen, E. J. (1999). Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin. Infect Immun 67, 3900-3908.
51. Throm, R. E. & Spinola, S. M. (2001). Transcription of candidate virulence genes of Haemophilus ducreyi during infection of human volunteers. Infect Immun 69, 1483-1487.
52. Throm, R. E., Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P., Hood, A. F., Hansen, E. J. & Spinola, S. M. (2000). Evaluation of an isogenic MOMP-deficient mutant in the human model of Haemophilus ducreyi infection. Infect Immun 68, 2602-2607.
53. Vakevainen, M, Greenberg, S. & Hansen, F. J. (2003). Inhibition of phagocytosis by Haemophilus ducreyi requires expression of the LspA1 and LspA2 proteins. Infect Immun 71, 5994-6003.
54. Ward, C. K., Lumbley, S. R., Latimer, J. L., Cope, L. D. & Hansen, E. J. (1998). Haemophilus ducreyi secretes a filamentous hemagglutinin-like protein. J Bacteriol 180, 6013-6022.
55. Young, R. S., Fortney, K. R., Gelfanova, V., Phillips, C. L., Katz, B. P., Hood, A. F., Latimer, J. L., Munson, R. S., Jr, Hansen, E. J. & Spinola, S. M. (2001). Expression of cytolethal distending toxin and hemolysin are not required for pustule formation by Haemophilus ducreyi in human volunteers. Infect Immun 69, 1938-1942.