Localization of Haemophilus ducreyi at the pustular stage of disease in the human model of infection

Infection and Immunity

Volumn 68, Issue 4, 2000, Pages 2309-2314

  Bauer, Margaret E ^a   Spinola, Stanley M ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OUTER MEMBRANE PROTEIN;

ANTIBODY SPECIFICITY; ARTICLE; BACTERIAL INFECTION; BIOPSY; EPITHELIUM CELL; FIBROBLAST; HAEMOPHILUS DUCREYI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFLAMMATORY CELL; KERATINOCYTE; PRIORITY JOURNAL; PUSTULE; SEXUALLY TRANSMITTED DISEASE; TISSUE DISTRIBUTION; ULCUS MOLLE;

ADULT; ANTIBODIES, MONOCLONAL; CHANCROID; DERMIS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HAEMOPHILUS DUCREYI; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; SKIN;

EID: 0034100625     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.4.2309-2314.2000     Document Type: Article

References (32)

1. Abeck, D., A. P. Johnson, and H. Mensing. 1992. Binding of Haemophilus ducreyi to extracellular matrix proteins. Microb. Pathog. 13:81-84.
2. Alfa, M. J., P. Degagne, and T. Hollyer. 1993. Haemophilus ducreyi adheres to but does not invade cultured human foreskin cells. Infect. Immun. 61: 1735-1742.
3. Al-Tawfiq, J., J. Harezlak, B. P. Katz, and S. M. Spinola. 2000. Cumulative experience with Haemophilus ducreyi in the human model of experimental infection. Sex. Transm. Dis. 27:111-114.
4. Al-Tawfiq, J. A., M. E. Bauer, K. R. Fortney, B. P. Katz, A. F. Hood, M. Ketterer, M. A. Apicella, and S. M. Spinola. A pilus-deficient mutant of Haemophilus ducreyi is virulent in the human model of experimental infection. J. Infect. Dis., in press.
5. Al-Tawfiq, J. A., K. R. Fortney, B. P. Katz, C. Elkins, and S. M. Spinola. An isogenic hemoglobin receptor-deficient mutant of Haemophilus ducreyi is attenuated in the human model of experimental infection. J. Infect. Dis., in press.
6. Al-Tawfiq, J. A., A. C. Thornton, B. P. Katz, K. R. Fortney, K. D. Todd, A. F. Hood, and S. M. Spinola. 1998. Standardization of the experimental model of Haemophilus ducreyi infection in human subjects. J. Infect. Dis. 178: 1684-1687.
7. Bauer, M. E., and S. M. Spinola. 1999. Binding of Haemophilus ducreyi to extracellular matrix proteins. Infect. Immun. 67:2649-2653.
8. Brentjens, R. J., M. Ketterer, M. A. Apicella, and S. M. Spinola. 1996. Fine tangled pili expressed by Haemophilus ducreyi are a novel class of pili. J. Bacteriol. 178:808-816.
9. Brentjens, R. J., S. M. Spinola, and A. A. Campagnari. 1994. Haemophilus ducreyi adheres to human keratinocytes. Microb. Pathog. 16:243-247.
10. Fleming, D. T., and J. N. Wasserheit. 1999. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex. Transm. Infect. 75:3-17.
11. Freinkel, A. L. 1987. Histological aspects of sexually transmitted genital lesions. Histopathology 11:819-831.
12. Hammond, G. W., M. Slutchuk, J. Scatliff, E. Sherman, J. C. Wilt, and A. R. Ronald. 1980. Epidemiologic, clinical, laboratory, and therapeutic features of an urban outbreak of chancroid in North America. Rev. Infect. Dis. 2: 867-879.
13. Hansen, E. J., and T. A. Loftus. 1984. Monoclonal antibodies reactive with all strains of Haemophilus ducreyi. Infect. Immun. 44:196-198.
14. Heyman, A., P. B. Beeson, and W. H. Sheldon. 1945. Diagnosis of chancroid. JAMA 129:935-938.
15. Hiltke, T. J., M. E. Bauer, J. Klesney-Tait, E. J. Hansen, R. S. Munson, Jr., and S. M. Spinola. 1999. Effect of normal and immune sera on Haemophilus ducreyi 35000HP and its isogenic MOMP and LOS mutants. Microb. Pathog. 26:93-102.
16. Hiltke, T. J., A. A. Campagnari, and S. M. Spinola. 1996. Characterization of a novel lipoprotein expressed by Haemophilus ducreyi. Infect. Immun. 64: 5047-5052.
17. Klesney-Tait, J., T. J. Hiltke, I. Maciver, S. M. Spinola, J. D. Radolf, and E. J. Hansen. 1997. The major outer membrane protein of Haemophilus ducreyi consists of two OmpA homologs. J. Bacteriol. 179:1764-1773.
18. Lagergard, T., M. Purven, and A. Frisk. 1993. Evidence of Haemophilus ducreyi adherence to and cytotoxin destruction of human epithelial cells. Microb. Pathog. 14:417-431.
19. Lammel, C. J., N. P. Dekker, J. Palefsky, and G. F. Brooks. 1993. In vitro model of Haemophilus ducreyi adherence to and entry into eukaryotic cells of genital origin. J. Infect. Dis. 167:642-650.
20. Magro, C. M., A. N. Crowson, M. Alfa, A. Nath, A. Ronald, J. O. Ndinya-Achola, and J. Nasio. 1996. A morphological study of penile chancroid lesions in human immunodeficiency virus (HIV)-positive and -negative African men with a hypothesis concerning the role of chancroid in HIV transmission. Hum. Pathol. 27:1066-1070.
21. Marsch, W. C., N. Haas, and G. Stuttgen. 1978. Ultrastructural detection of Haemophilus ducreyi in biopsies of chancroid. Arch. Dermatol. Res. 263: 153-157.
22. Morse, S. A. 1989. Chancroid and Haemophilus ducreyi. Clin. Microbiol. Rev. 2:137-157.
23. Ortiz-Zepeda, C., E. Hernandez-Perez, and R. Marroquin-Burgos. 1994. Gross and microscopic features in chancroid: a study in 200 new culture-proven cases in San Salvador. Sex. Transm. Dis. 21:112-117.
24. Palmer, K. L., C. T. Schnizlein-Bick, A. Orazi, K. John, C.-Y. Chen, A. F. Hood, and S. M. Spinola. 1998. The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects. J. Infect. Dis. 178:1688-1697.
25. Sheldon, W. H., and A. Heyman. 1946. Studies on chancroid. I. Observations on the histology with an evaluation of biopsy as a diagnostic procedure. Am. J. Pathol. 22:415-425.
26. Spinola, S. M., G. E. Griffiths, J. A. Bogdan, and M. A. Menegus. 1992. Characterization of an 18,000-molecular-weight outer membrane protein of Haemophilus ducreyi that contains a conserved surface-exposed epitope. Infect. Immun. 60:385-391.
27. Spinola, S. M., G. E. Griffiths, K. L. Shanks, and M. S. Blake. 1993. The major outer membrane protein of Haemophilus ducreyi is a member of the OmpA family of proteins. Infect. Immun. 61:1346-1351.
28. Spinola, S. M., A. Orazi, J. N. Arno, K. Fortney, P. Kotylo, C.-Y. Chen, A. A. Campagnari, and A. F. Hood. 1996. Haemophilus ducreyi elicits a cutaneous infiltrate of CD4 cells during experimental human infection. J. Infect. Dis. 173:394-402.
29. Spinola, S. M., L. M. Wild, M. A. Apicella, A. A. Gaspari, and A. A. Campagnari. 1994. Experimental human infection with Haemophilus ducreyi. J. Infect. Dis. 169:1145-1150.
30. 29a. Throm, R. E., J. A. Al-Tawfig, K. R. Fortney, B. P. Katz, A. F. Hood, C. A. Slaughter, E. J. Hansen, and S. M. Spinola. Evaluation of an isogenic major outer membrane protein-deficient mutant in the human model of Haemophilus ducreyi infection. Infect. Immun., in press.
31. Totten, P. A., J. C. Lara, D. V. Norn, and W. E. Stamm. 1994. Haemophilus ducreyi attaches to and invades human epithelial cells in vitro. Infect. Immun. 62:5632-5640.
32. Young, R. S., K. Fortney, J. C. Haley, A. F. Hood, A. A. Campagnari, J. Wang, J. A. Bozue, R. S. Munson, Jr., and S. M. Spinola. 1999. Expression of sialylated or paragloboside-like lipooligosaccharides are not required for pustule formation by Haemophilus ducreyi in human volunteers. Infect. Immun. 67:6335-6340.