메뉴 건너뛰기




Volumn 5, Issue 2, 2008, Pages 234-242

In vivo and in vitro production options for fungal secondary metabolites

Author keywords

Biotransformation; Fungi; Genomics; Heterologous expression; Natural products; Pharmaceutical biotechnology; Secondary metabolism

Indexed keywords

NATURAL PRODUCT;

EID: 42549126178     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp7001544     Document Type: Review
Times cited : (62)

References (63)
  • 1
    • 30544434099 scopus 로고    scopus 로고
    • Fungal secondary metabolism - from biochemistry to genomics
    • Keller, N. P.; Turner, G.; Bennett, J. W. Fungal secondary metabolism - from biochemistry to genomics. Nat. Rev. Microbiol. 2005, 3, 937-947.
    • (2005) Nat. Rev. Microbiol , vol.3 , pp. 937-947
    • Keller, N.P.1    Turner, G.2    Bennett, J.W.3
  • 2
    • 14944383798 scopus 로고    scopus 로고
    • The evolving role of natural products in drug discovery
    • Koehn, F. E.; Carter, G. T. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discovery 2005, 4, 206-220.
    • (2005) Nat. Rev. Drug Discovery , vol.4 , pp. 206-220
    • Koehn, F.E.1    Carter, G.T.2
  • 4
    • 34249811180 scopus 로고    scopus 로고
    • New aspects of natural products in drug discovery
    • Lam, K. S. New aspects of natural products in drug discovery. Trends Microbiol. 2007, 15, 279-289.
    • (2007) Trends Microbiol , vol.15 , pp. 279-289
    • Lam, K.S.1
  • 5
    • 34250379220 scopus 로고    scopus 로고
    • Fungal genetics, genomics, and secondary metabolites in pharmaceutical sciences
    • Misiek, M.; Hoffmeister, D. Fungal genetics, genomics, and secondary metabolites in pharmaceutical sciences. Planta Med. 2007, 73, 103-115.
    • (2007) Planta Med , vol.73 , pp. 103-115
    • Misiek, M.1    Hoffmeister, D.2
  • 6
    • 34250701119 scopus 로고    scopus 로고
    • Mining and engineering natural-product biosynthetic Pathways
    • Wilkinson, B.; Micklefield, J. Mining and engineering natural-product biosynthetic Pathways. Nat. Chem. Biol. 2007, 3, 379-386.
    • (2007) Nat. Chem. Biol , vol.3 , pp. 379-386
    • Wilkinson, B.1    Micklefield, J.2
  • 7
    • 33947694781 scopus 로고    scopus 로고
    • Natural products of filamentous fungi: Enzymes, genes, and their regulation
    • Hoffmeister, D.; Keller, N. P. Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat. Prod. Rep. 2007, 24, 393-416.
    • (2007) Nat. Prod. Rep , vol.24 , pp. 393-416
    • Hoffmeister, D.1    Keller, N.P.2
  • 8
    • 0042844744 scopus 로고    scopus 로고
    • Natural Products as Sources of New Drugs over the Period 1981-2002
    • Newman, D. L.; Cragg, G. M.; Snader, K. M. Natural Products as Sources of New Drugs over the Period 1981-2002. J. Nat. Prod. 2003, 66, 1022-1037.
    • (2003) J. Nat. Prod , vol.66 , pp. 1022-1037
    • Newman, D.L.1    Cragg, G.M.2    Snader, K.M.3
  • 9
    • 34247109045 scopus 로고    scopus 로고
    • Natural Products as Sources of New Drugs over the Last 25 Years
    • Newman, D. L.; Cragg, G. M. Natural Products as Sources of New Drugs over the Last 25 Years. J. Nat. Prod. 2007, 70, 461-477.
    • (2007) J. Nat. Prod , vol.70 , pp. 461-477
    • Newman, D.L.1    Cragg, G.M.2
  • 12
    • 42549136408 scopus 로고    scopus 로고
    • Strain improvement for the production of fungal secondary metabolites
    • An, Z, Ed, Marcel Dekker: New York
    • Masurekar, P. S. Strain improvement for the production of fungal secondary metabolites. In Handbook of Industrial Mycology; An, Z., Ed., Marcel Dekker: New York, 2005; pp 539561.
    • (2005) Handbook of Industrial Mycology , pp. 539561
    • Masurekar, P.S.1
  • 13
    • 0038236925 scopus 로고    scopus 로고
    • Industrial production of beta-lactam antibiotics
    • Elander, R. P. Industrial production of beta-lactam antibiotics. Appl. Microbiol. Biotechnol. 2003, 61, 385-392.
    • (2003) Appl. Microbiol. Biotechnol , vol.61 , pp. 385-392
    • Elander, R.P.1
  • 14
    • 34047211977 scopus 로고    scopus 로고
    • 0 production by fermentation of the fungus Glarea lozoyensis: Physiological and engineering factors affecting titer and structural analogues formation
    • An, Z, Ed, Marcel Dekker: New York
    • 0 production by fermentation of the fungus Glarea lozoyensis: physiological and engineering factors affecting titer and structural analogues formation. In Handbook of Industrial Mycology; An, Z., Ed.; Marcel Dekker: New York, 2005; pp 515-538..
    • (2005) Handbook of Industrial Mycology , pp. 515-538
    • Connors, N.1    Pollard, D.2
  • 15
    • 0036902202 scopus 로고    scopus 로고
    • Big effects from small changes: Possible ways to explore nature's chemical diversity
    • Bode, H. B.; Bethe, B.; Hofs, R.; Zeeck, A. Big effects from small changes: possible ways to explore nature's chemical diversity. ChemBioChem 2002, 3, 619-627.
    • (2002) ChemBioChem , vol.3 , pp. 619-627
    • Bode, H.B.1    Bethe, B.2    Hofs, R.3    Zeeck, A.4
  • 16
    • 0032987471 scopus 로고    scopus 로고
    • Sphaeric acid, a new succinic acid derivative from a Sphaeropsis sp
    • Wilkinson, R. A.; Strobel, G.; Stierle, A. Sphaeric acid, a new succinic acid derivative from a Sphaeropsis sp. J. Nat. Prod. 1999, 62, 358-360.
    • (1999) J. Nat. Prod , vol.62 , pp. 358-360
    • Wilkinson, R.A.1    Strobel, G.2    Stierle, A.3
  • 17
    • 38349050412 scopus 로고    scopus 로고
    • Uncovering Biosynthetic Potential of Plant-Associated Fungi: Effect of Culture Conditions on Metabolite Production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii
    • Paranagama, P. A.; Wijeratne, E. M.; Gunatilaka, A. A. Uncovering Biosynthetic Potential of Plant-Associated Fungi: Effect of Culture Conditions on Metabolite Production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii. J. Nat. Prod. 2007, 70, 1939-1945.
    • (2007) J. Nat. Prod , vol.70 , pp. 1939-1945
    • Paranagama, P.A.1    Wijeratne, E.M.2    Gunatilaka, A.A.3
  • 18
    • 0035712954 scopus 로고    scopus 로고
    • The magnitude of fungal diversity: The 1.5 million species estimate revisited
    • Hawksworth, D. L. The magnitude of fungal diversity: the 1.5 million species estimate revisited. Mycol. Res. 2001, 105, 1422-1432.
    • (2001) Mycol. Res , vol.105 , pp. 1422-1432
    • Hawksworth, D.L.1
  • 19
    • 0038700488 scopus 로고    scopus 로고
    • Putting nature back into drug discovery
    • Müller-Kuhrt, L. Putting nature back into drug discovery. Nat. Biotechnol. 2003, 21, 602.
    • (2003) Nat. Biotechnol , vol.21 , pp. 602
    • Müller-Kuhrt, L.1
  • 22
    • 38849174356 scopus 로고    scopus 로고
    • Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: Combining synthetic chemistry and biosynthetic engineering for diversifying natural products
    • Kennedy, J. Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products. Nat. Prod. Rep. 2008, 25, 25-34.
    • (2008) Nat. Prod. Rep , vol.25 , pp. 25-34
    • Kennedy, J.1
  • 23
    • 0033051211 scopus 로고    scopus 로고
    • The beta-lactam antibiotics: Past, present, and future
    • Demain, A. L.; Elander, E. P. The beta-lactam antibiotics: past, present, and future. Antonie van Leeuwenhoek 1999, 75, 5-19.
    • (1999) Antonie van Leeuwenhoek , vol.75 , pp. 5-19
    • Demain, A.L.1    Elander, E.P.2
  • 24
    • 35348843398 scopus 로고    scopus 로고
    • Cytotoxic and Antihaptotactic Beauvericin Analogues from Precursor-Directed Biosynthesis with the Insect Pathogen Beauveria bassiana ATCC 7159
    • Xu, Y.; Zhan, J.; Kithsiri, E. M.; Burns, A. M.; Gunatilaka, A. A. L.; Molnár, I. Cytotoxic and Antihaptotactic Beauvericin Analogues from Precursor-Directed Biosynthesis with the Insect Pathogen Beauveria bassiana ATCC 7159. J. Nat. Prod. 2007, 70, 1467-1471.
    • (2007) J. Nat. Prod , vol.70 , pp. 1467-1471
    • Xu, Y.1    Zhan, J.2    Kithsiri, E.M.3    Burns, A.M.4    Gunatilaka, A.A.L.5    Molnár, I.6
  • 25
    • 33845405178 scopus 로고    scopus 로고
    • Microbial Transformation of Amino-and Hydroxyanthraquinones by Beauveria bassiana ATCC 7159
    • Zhan, J.; Gunatilaka, A. A. L. Microbial Transformation of Amino-and Hydroxyanthraquinones by Beauveria bassiana ATCC 7159. J. Nat. Prod. 2006, 69, 1525-1527.
    • (2006) J. Nat. Prod , vol.69 , pp. 1525-1527
    • Zhan, J.1    Gunatilaka, A.A.L.2
  • 26
    • 32644473666 scopus 로고    scopus 로고
    • Natural and directed biosynthesis of communesin alkaloids
    • Wigley, L. J.; Mantle, P. G.; Perry, D. A. Natural and directed biosynthesis of communesin alkaloids. Phytochemistry 2006, 67, 561-569.
    • (2006) Phytochemistry , vol.67 , pp. 561-569
    • Wigley, L.J.1    Mantle, P.G.2    Perry, D.A.3
  • 27
    • 0027527424 scopus 로고
    • The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis
    • Cannell, R. J.; Dawson, M. J.; Hale, R. S.; Hall, R. M.; Noble, D.; Lynn, S.; Taylor, N. L. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis. J. Antibiot. 1993, 46, 1381-1389.
    • (1993) J. Antibiot , vol.46 , pp. 1381-1389
    • Cannell, R.J.1    Dawson, M.J.2    Hale, R.S.3    Hall, R.M.4    Noble, D.5    Lynn, S.6    Taylor, N.L.7
  • 28
    • 23944505982 scopus 로고    scopus 로고
    • Heterologous protein expression in filamentous fungi
    • Nevalainen, K. M.; Te'o, V. S.; Bergquist, P. L. Heterologous protein expression in filamentous fungi. Trends Biotechnol. 2005, 23, 468-474.
    • (2005) Trends Biotechnol , vol.23 , pp. 468-474
    • Nevalainen, K.M.1    Te'o, V.S.2    Bergquist, P.L.3
  • 29
    • 33751092257 scopus 로고    scopus 로고
    • Biosynthesis of Lovastatin Analogs with a Broadly Specific Acyltransferase
    • Xie, X.; Watanabe, K.; Wojcicki, W. A.; Wang, C. C.; Tang, Y. Biosynthesis of Lovastatin Analogs with a Broadly Specific Acyltransferase. Chem. Biol. 2006, 13, 1161-1169.
    • (2006) Chem. Biol , vol.13 , pp. 1161-1169
    • Xie, X.1    Watanabe, K.2    Wojcicki, W.A.3    Wang, C.C.4    Tang, Y.5
  • 30
    • 0026660914 scopus 로고
    • Genetic engineering of beta-lactam antibiotic biosynthetic pathways in filamentous fungi
    • Skatrud, P. L. Genetic engineering of beta-lactam antibiotic biosynthetic pathways in filamentous fungi. Trends Biotechnol. 1992, 10, 324-329.
    • (1992) Trends Biotechnol , vol.10 , pp. 324-329
    • Skatrud, P.L.1
  • 31
    • 0029995755 scopus 로고    scopus 로고
    • δ-(L-α-aminoadipyl)-L-cysteinyl-D- valine synthethase is a rate limiting enzyme for penicillin production in Aspergillus nidulans
    • Kennedy, J.; Turner, G. δ-(L-α-aminoadipyl)-L-cysteinyl-D- valine synthethase is a rate limiting enzyme for penicillin production in Aspergillus nidulans. Mol. Gen. Genet. 1996, 253, 189-197.
    • (1996) Mol. Gen. Genet , vol.253 , pp. 189-197
    • Kennedy, J.1    Turner, G.2
  • 32
    • 33947267597 scopus 로고    scopus 로고
    • Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes
    • Ullán, R. V.; Campoy, S.; Casqueiro, J.; Fernandez, F. J.; Martín, J. F. Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes. Chem. Biol. 2007, 14, 329-339.
    • (2007) Chem. Biol , vol.14 , pp. 329-339
    • Ullán, R.V.1    Campoy, S.2    Casqueiro, J.3    Fernandez, F.J.4    Martín, J.F.5
  • 33
    • 0033591447 scopus 로고    scopus 로고
    • Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis
    • Kennedy, J.; Auclair, K.; Kendrew, S. G.; Park, C.; Vederas, J. C.; Hutchinson, C. R. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science 1999, 284, 1368-1372.
    • (1999) Science , vol.284 , pp. 1368-1372
    • Kennedy, J.1    Auclair, K.2    Kendrew, S.G.3    Park, C.4    Vederas, J.C.5    Hutchinson, C.R.6
  • 34
    • 0038481075 scopus 로고    scopus 로고
    • Sorensen, J. L.; Vederas, J. C. Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin. Chem. Commun. 2003, 1492-1493.
    • Sorensen, J. L.; Vederas, J. C. Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin. Chem. Commun. 2003, 1492-1493.
  • 35
    • 34848890676 scopus 로고    scopus 로고
    • Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi
    • Ma, S. M.; Zhan, J.; Watanabe, K.; Xie, X.; Zhang, W.; Wang, C. C.; Tang, Y. Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J. Am. Chem. Soc. 2007, 129, 10642-10643.
    • (2007) J. Am. Chem. Soc , vol.129 , pp. 10642-10643
    • Ma, S.M.1    Zhan, J.2    Watanabe, K.3    Xie, X.4    Zhang, W.5    Wang, C.C.6    Tang, Y.7
  • 36
    • 38349000749 scopus 로고    scopus 로고
    • Redirecting the Cyclization Steps of Fungal Polyketide Synthase
    • Ma, S. M.; Zhan, J.; Xie, X.; Watanabe, K.; Tang, Y.; Zhang, W. Redirecting the Cyclization Steps of Fungal Polyketide Synthase. J. Am. Chem. Soc. 2008, 130, 38-39.
    • (2008) J. Am. Chem. Soc , vol.130 , pp. 38-39
    • Ma, S.M.1    Zhan, J.2    Xie, X.3    Watanabe, K.4    Tang, Y.5    Zhang, W.6
  • 37
    • 35348938266 scopus 로고    scopus 로고
    • In vitro synthesis of new enniatins: Probing the alpha-D-hydroxy carboxylic acid binding pocket of the multienzyme enniatin synthetase
    • Feifel, S. C.; Schmiederer, T.; Hornbogen, T.; Berg, H.; Süssmuth, R. D.; Zocher, R. In vitro synthesis of new enniatins: probing the alpha-D-hydroxy carboxylic acid binding pocket of the multienzyme enniatin synthetase. ChemBioChem 2007, 8, 1767-1770.
    • (2007) ChemBioChem , vol.8 , pp. 1767-1770
    • Feifel, S.C.1    Schmiederer, T.2    Hornbogen, T.3    Berg, H.4    Süssmuth, R.D.5    Zocher, R.6
  • 38
    • 34250372830 scopus 로고    scopus 로고
    • A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones
    • Schneider, P.; Weber, M.; Rosenberger, K.; Hoffmeister, D. A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones. Chem. Biol. 2007, 14, 635-644.
    • (2007) Chem. Biol , vol.14 , pp. 635-644
    • Schneider, P.1    Weber, M.2    Rosenberger, K.3    Hoffmeister, D.4
  • 39
    • 34548069725 scopus 로고    scopus 로고
    • Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation
    • Balibar, C. J.; Howard-Jones, A. R.; Walsh, C. T. Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation. Nat. Chem. Biol. 2007, 3, 584-592.
    • (2007) Nat. Chem. Biol , vol.3 , pp. 584-592
    • Balibar, C.J.1    Howard-Jones, A.R.2    Walsh, C.T.3
  • 40
    • 29244442741 scopus 로고    scopus 로고
    • Genome sequencing and analysis of Aspergillus oryzae
    • Machida, M.; Asai, K.; Sano, M.; Tanaka, T.; Kumagai, T.; Terai, G.; et al. Genome sequencing and analysis of Aspergillus oryzae. Nature 2005, 438, 1157-1161.
    • (2005) Nature , vol.438 , pp. 1157-1161
    • Machida, M.1    Asai, K.2    Sano, M.3    Tanaka, T.4    Kumagai, T.5    Terai, G.6
  • 41
    • 33846861493 scopus 로고    scopus 로고
    • Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
    • Pel, H. P.; de Winde, J. H.; Archer, D. B.; Dyer, P. S.; Hofmann, G.; Schaap, P. J.; et al. Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat. Biotechnol. 2007, 25, 221-231.
    • (2007) Nat. Biotechnol , vol.25 , pp. 221-231
    • Pel, H.P.1    de Winde, J.H.2    Archer, D.B.3    Dyer, P.S.4    Hofmann, G.5    Schaap, P.J.6
  • 42
    • 0037316031 scopus 로고    scopus 로고
    • Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains
    • Askenazi, M.; Driggers, E. M.; Holtzman, D. A.; Norman, T. C.; Iverson, S.; Zimmer, D. P.; et al. Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains. Nat. Biotechnol. 2003, 21, 150-156.
    • (2003) Nat. Biotechnol , vol.21 , pp. 150-156
    • Askenazi, M.1    Driggers, E.M.2    Holtzman, D.A.3    Norman, T.C.4    Iverson, S.5    Zimmer, D.P.6
  • 44
    • 34548070930 scopus 로고    scopus 로고
    • Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA
    • Bouhired, S.; Weber, M.; Kempf-Sontag, A.; Keller, N. P.; Hoffmeister, D. Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet. Biol. 2007, 44, 1134-1145.
    • (2007) Fungal Genet. Biol , vol.44 , pp. 1134-1145
    • Bouhired, S.1    Weber, M.2    Kempf-Sontag, A.3    Keller, N.P.4    Hoffmeister, D.5
  • 47
    • 33748254906 scopus 로고    scopus 로고
    • Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining
    • Scherlach, K.; Hertweck, C. Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining. Org. Biomol. Chem. 2006, 4, 3517-3520.
    • (2006) Org. Biomol. Chem , vol.4 , pp. 3517-3520
    • Scherlach, K.1    Hertweck, C.2
  • 48
    • 37649025262 scopus 로고    scopus 로고
    • Jacobs, M. R. Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children. Future Microbiol. 2007, 2, 591-600.
    • Jacobs, M. R. Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children. Future Microbiol. 2007, 2, 591-600.
  • 49
    • 33845873055 scopus 로고    scopus 로고
    • Irofulven as first line therapy in recurrent or metastatic gastric cancer: A phase II multicenter study by the Cancer Therapeutics Research Group (CTRG)
    • Yeo, W.; Boyer, M.; Chung, H. C.; Ong, S. Y.; Lim, R.; Zee, B.; et al. Irofulven as first line therapy in recurrent or metastatic gastric cancer: a phase II multicenter study by the Cancer Therapeutics Research Group (CTRG). Cancer Chemother. Pharmacol. 2007, 59, 295-300.
    • (2007) Cancer Chemother. Pharmacol , vol.59 , pp. 295-300
    • Yeo, W.1    Boyer, M.2    Chung, H.C.3    Ong, S.Y.4    Lim, R.5    Zee, B.6
  • 50
    • 35848949294 scopus 로고    scopus 로고
    • McMorris, T. C.; Chimmani, R.; Gurram, M.; Staake, M. D.; Keiner, M. J. Synthesis and antitumor activity of amine analogs of irofulven. Bioorg. Med. Chem. Lett. 2007, 17, 6770-6772.
    • McMorris, T. C.; Chimmani, R.; Gurram, M.; Staake, M. D.; Keiner, M. J. Synthesis and antitumor activity of amine analogs of irofulven. Bioorg. Med. Chem. Lett. 2007, 17, 6770-6772.
  • 52
    • 33646118484 scopus 로고    scopus 로고
    • NPI-2358 is a tubulin-depolymerizing agent: In-vitro evidence for activity as a tumor vascular-disrupting agent
    • Nicholson, B.; Lloyd, G. K.; Miller, B. R.; Palladino, M. A.; Kiso, Y.; Hayashi, Y.; Neuteboom, S. T. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs 2006, 17, 25-31.
    • (2006) Anticancer Drugs , vol.17 , pp. 25-31
    • Nicholson, B.1    Lloyd, G.K.2    Miller, B.R.3    Palladino, M.A.4    Kiso, Y.5    Hayashi, Y.6    Neuteboom, S.T.7
  • 53
    • 37249061370 scopus 로고    scopus 로고
    • Heptaketides from Corynespora sp. Inhabiting the Cavern Beard Lichen Usnea cavernosa: First Report of Metabolites of an Endolichenic Fungus
    • Paranagama, P. A.; Wijeratne, E. M.; Burns, A. M.; Marron, M. T.; Gunatilaka, M. K.; Arnold, A. E.; Gunatilaka, A. A. Heptaketides from Corynespora sp. Inhabiting the Cavern Beard Lichen Usnea cavernosa: First Report of Metabolites of an Endolichenic Fungus. J. Nat. Prod. 2007, 70, 1700-1705.
    • (2007) J. Nat. Prod , vol.70 , pp. 1700-1705
    • Paranagama, P.A.1    Wijeratne, E.M.2    Burns, A.M.3    Marron, M.T.4    Gunatilaka, M.K.5    Arnold, A.E.6    Gunatilaka, A.A.7
  • 54
    • 34249098395 scopus 로고    scopus 로고
    • Kemami Wangun, H. V.; Dahse, H.-M.; Hertweck, C. Epicoccarines A, B and epipyridone: tetramic acids and pyridone alkaloids from an Epicoccum sp. associated with the tree fungus Pholiota squarrosa. Org. Biomol. Chem. 2007, 5, 1702-1705.
    • Kemami Wangun, H. V.; Dahse, H.-M.; Hertweck, C. Epicoccarines A, B and epipyridone: tetramic acids and pyridone alkaloids from an Epicoccum sp. associated with the tree fungus Pholiota squarrosa. Org. Biomol. Chem. 2007, 5, 1702-1705.
  • 57
    • 1442310075 scopus 로고    scopus 로고
    • Natural products from endophytic microorganisms
    • Strobel, G.; Daisy, B.; Castillo, U.; Harper, J. Natural products from endophytic microorganisms. J. Nat. Prod. 2004, 67, 257-268.
    • (2004) J. Nat. Prod , vol.67 , pp. 257-268
    • Strobel, G.1    Daisy, B.2    Castillo, U.3    Harper, J.4
  • 58
    • 33645978063 scopus 로고    scopus 로고
    • Natural products from plant-associated microorganisms: Distribution, structural diversity, bioactivity, and implications of their occurrence
    • Gunatilaka, A. A. Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence. J. Nat. Prod. 2006, 69, 509-526.
    • (2006) J. Nat. Prod , vol.69 , pp. 509-526
    • Gunatilaka, A.A.1
  • 62
    • 33744517549 scopus 로고    scopus 로고
    • Harnessing endophytes for industrial microbiology
    • Strobel, G. A. Harnessing endophytes for industrial microbiology. Curr. Opin. Microbiol. 2006, 9, 240-244.
    • (2006) Curr. Opin. Microbiol , vol.9 , pp. 240-244
    • Strobel, G.A.1
  • 63
    • 27144465524 scopus 로고    scopus 로고
    • Pathogenic fungus harbours endosymbiotic bacteria for toxin production
    • Partida-Martinez, L. P.; Hertweck, C. Pathogenic fungus harbours endosymbiotic bacteria for toxin production. Nature 2005, 437, 884-888.
    • (2005) Nature , vol.437 , pp. 884-888
    • Partida-Martinez, L.P.1    Hertweck, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.