A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 12, 2008, Pages 4615-4620

  Hu, Jie ^a,b   Ma, Ao ^a   Dinner, Aaron R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Commitment probabilities; DNA repair; Reaction coordinates; Transition path sampling

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ANTINEOPLASTIC AGENT; CYSTEINE; DNA BASE; GUANINE; NUCLEOTIDE; THYMINE; TYROSINE; DNA; DRUG DERIVATIVE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE; UNCLASSIFIED DRUG;

ARTICLE; DNA DAMAGE; DNA REPAIR; ELECTRICITY; ENERGY TRANSFER; ENZYME ACTIVITY; ENZYME STRUCTURE; GENOME; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; THERMODYNAMICS; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; HUMAN; KINETICS; METABOLISM; PROTEIN SECONDARY STRUCTURE;

BINDING SITES; COMPUTER SIMULATION; DNA; DNA DAMAGE; ELECTROSTATICS; GUANINE; HUMANS; KINETICS; NUCLEIC ACID CONFORMATION; NUCLEOTIDES; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS; TYROSINE;

EID: 42449162353     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708058105     Document Type: Article

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