Gabapentin produces PKA-dependent pre-synaptic inhibition of GABAergic synaptic transmission in LC neurons following partial nerve injury in mice

Journal of Neurochemistry

Volumn 105, Issue 3, 2008, Pages 933-942

  Takasu, Keiko ^a   Ono, Hideki ^a   Tanabe, Mitsuo ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

GABAergic inhibitory post synaptic currents; Gabapentin; Locus coeruleus; Neuropathic pain; Paired pulse ratio; Protein kinase

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; BICUCULLINE METHOBROMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GABAPENTIN; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; INHIBITORY POSTSYNAPTIC POTENTIAL; LOCUS CERULEUS; MALE; MOUSE; NERVE CELL; NERVE ENDING; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NERVE INJURY; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION;

AMINES; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOHEXANECARBOXYLIC ACIDS; EFFERENT PATHWAYS; ENZYME ACTIVATION; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; INHIBITORY POSTSYNAPTIC POTENTIALS; LIGATION; LOCUS COERULEUS; MALE; MICE; NEURAL INHIBITION; NOCICEPTORS; ORGAN CULTURE TECHNIQUES; PAIN; PATCH-CLAMP TECHNIQUES; PERIPHERAL NERVOUS SYSTEM DISEASES; POSTERIOR HORN CELLS; PRESYNAPTIC TERMINALS; RECEPTORS, GABA-A; SCIATIC NEUROPATHY; SYNAPTIC TRANSMISSION;

MUS;

EID: 42449161597     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05212.x     Document Type: Article

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