Histopathology of EAE

Experimental Models of Multiple Sclerosis

Volumn , Issue , 2005, Pages 25-43

  Day, Michael J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

demyelination; EAE; histopathology; inflammation; multiple sclerosis

Indexed keywords

EID: 42449155420     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/0-387-25518-4_3     Document Type: Chapter

References (50)

1. Aloisi F, Serafini B and Adorini L, 2000. Glia-T cell dialogue. Journal of Neuroimmunology 107:111-117.
2. Anthony DC, Hughes P and Perry VH, 2000. The evidence for primary axonal loss in multiple sclerosis. Revista de Neurologia 30: 1203-1208.
3. Baker D, O'Neill JK, Gschmeissner SE, Wilcox CE, Butter C and Turk JL, 1990. Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice. Journal of Neuroimmunology 28: 261-270.
4. Baumann N and Pham-Dinh D, 2001. Biology of oligodendrocytes and myelin in the mammalian central nervous system. Physiological Reviews 81:671-927.
5. Bettelli E, Das MP, Howard ED, Weiner HL, Sobel RA and Kuchroo VJ, 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of ILl0- And IL-4-deficient and transgenic mice. Journal of Immunology 161: 3299-3306.
6. Blakemore WF, Summers BA and Sedgwick J, 1989. Lymphocyte-myelin sheath interactions in acute experimental allergic encephalomyelitis. Journal of Neuroimmunology 23: 19-24.
7. Boztug K, Carson MJ, Pham-Mitchell N, Asensio VC, DeMartino J and Campbell IL, 2002. Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10. Journal of Immunology 169:1505-1515.
8. Brown A, Dale MD, McFarlin MD and Raine CS, 1982. Chronic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse. Laboratory Investigation 46: 171-185.
9. Chan A, Magnus T and Gold R, 2001. Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines Mechanism for removal of apoptotic cells in the inflamed nervous system. Glia 33: 87-95.
10. Couraud PO, 1998. Infiltration of inflammatory cells through brain endothelium. Pathologie Biologie 46: 176-180.
11. Dong YS and Benveniste EN, 2001. Immune function of astrocytes. Glia 36: 180-190.
12. Furlan R, Martino G, Galbiati F, Poliani PL, Smiroldo S, Bergami A, Desina G, Comi G, Flavell R, Su MS and Adorini L, 1999. Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. Journal of Immunology 163: 2403-2409.
13. Hart BA et al., 1998. Histological characterization of magnetic resonance imagingdetectable brain white matter lesions in a primate model of multiple sclerosis. American Journal of Pathology 153: 649-663.
14. Hart BA, van Meurs, M, Brok HPM, Massacesi L, Bauer J, Boon L, Bontrop RE and Laman JD, 2000. A new primate model for multiple sclerosis in the common marmoset. Immunology Today 21: 290-297.
15. Hickey WF, 1999. The pathology of multiple sclerosis: A historical perspective. Journal of Neuroimmunology 98:37-44.
16. Kieseier BC, Storch MK, Archelos JJ, Martino G and Hartung HP, 1999. Effect or pathways in immune mediated central nervous system demyelination. Current Opinion in Neurology 12: 323-336.
17. Langer-Gould A, Garren H, Slansky A, Ruiz PJ and Steinman L, 2002. Late pregnancy suppresses relapses in experimental autoimmune encephalomyelitis: evidence for a suppressive pregnancy-related serum factor. Journal of Immunology 169: 1084-1091.
18. Linington C, Bradl M, Lassmann H, Brunner C and Vass K, 1988. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. American Journal of Pathology 130: 443-454.
19. Luchinetti C, Bruck W, Parisi J et al., 2000. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Annals of Neurology 47:707-717.
20. Lyman WD, Sonett JR, Brosnan CF, Elkin R and Bornstem MB, 1989. Tetrahydrocannabinol: A novel treatment for experimental autoimmune encephalomyelit'rs. Journal of Neuroimmunology 23:73-81.
21. Lyons JA, Ramsbottom MJ and Cross AH, 2002. Critical role of antigen-specific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoprotein. European Journal of Immunology 32: 1905-1913.
22. Massey EJ, Sundstedt A, Day M J, Corfield G, Anderton S and Wraith DC, 2002. Intranasal peptide-induced peripheral tolerance: The role of IL-10 in regulatory T cell function within the context of experimental autoimmune encephalomyelitis. Veterinary Immunology and lmmunopathology 87: 357-372.
23. Matsumoto Y and Fujiwara M, 1988. Adoptively transferred experimental allergic encephalomyelitis in chimeric rats: Identification of transferred cells in the lesions of the central nervous system. Immunology 65: 23-29.
24. Minagawa H, Takenaka A, Itoyama Y and Mori R, 1987. Experimental allergic encephalomyelitis in the Lewis rat. A model of predictable relapse by cyclophosphamide. Journal of the Neurological Sciences 78: 225-235.
25. Nait-Oumesmar B, Lachapelle F, Decker L and Baron-Van Evercooren A, 2000. Do central nervous system axons remyelinate? Pathologie Biologie 48: 70-79.
26. O'Brien NC, Charlton B, Cowden WB and Willenborg DO, 1999. Nitric oxide plays a critical role in the recovery of Lewis rats from experimental autoimmune encephalomyelitis and the maintenance of resistance to reinduction. Journal of Immunology 163: 6841-6847.
27. Ouallet JC, Baumann N, Marie Y and Villarroya H, 1999. Fas system up-regulation in experimental autoimmune encephalomyelitis. Journal of the Neurological Sciences 170: 96- 104.
28. Pivneva TA, Kolotoushkina EV and Mel'nik NA, 1999. Mechanisms of the demyelination process and its modelling. Neurophysiology 31: 403-412.
29. Polman CH, Matthaei I, de Groot CJA, Koetsier JC, Sminia T and Dijkstra CD, 1988. Lowdose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat. Journal of Neuroimmunology 17:209-216.
30. Racke MK, Burnett D, Pak S-H, Albert PS, Cannella B, Raine CS, McFarlin DE and Scott DE, 1995. Retinoid treatment of experimental allergic encephalomyelitis. Journal of Immunology 154: 450-458.
31. Raine CS, Cannella B, Hauser SL and Genain CP, 1999. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: A case for antigenspecific antibody mediation. Annals of Neurology 46: 144-160.
32. Ransohoff RM, 1999. Mechanisms of inflammation in MS tissue: Adhesion molecules and chemokines. Journal of Neuroimmunology 98: 57-68.
33. Ransohoff RM, Howe CL and Rodriguez M, 2002. Growth factor treatment of demyelinating disease: At last, a leap into the light. Trends in Immunology 23: 512-516.
34. Rosenberg GA, 2002. Matrix metalloproteinases and neuroinflammation in multiple sclerosis. Neuroscientist 8: 586-587.
35. Schluesener HJ, Sobel RA and Weiner HL, 1988. Demyelinating experimental allergic encephalomyelitis (EAE) in the rat: Treatment with a monoclonal antibody against activated T cells. Journal of Neuroimmunology 18: 341-351.
36. Sedgwick J, Brostoff S and Mason D, 1987. Experimental allergic encephalomyelitis in the absence of a classical delayed type hypersensitivity reaction. Journal of Experimental Medicine 165: 1058-1075.
37. Sedgwick JD, 1988. Long-term depletion of CD8+T cells in vivo in the rat: no observed role for CD8 + (cytotoxic/suppressor) cells in the immunoregulation of experimental allergic encephalomyelitis. European Journal of Immunology 18: 495-502.
38. Smith ME, 1999. Phagocytosis of myelin in demyelinative disease: A review. Neurochemical Research 24:261-268.
39. Smith ME, 2001. Phagocytic properties of microglia in vitro: Implications for a role in multiple sclerosis in EAE. Microscopy Research and Technique 54: 87-94.
40. Spahn TW, Issazadah S, Salvin AJ and Weiner HL, 1999. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33-55-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR 8 chain gene. European Journal of Immunology 29:4060-4071.
41. Sternberger NH, Sternberger LA, Kies MW and Shear CR, 1989. Cell surface endothelial proteins altered in experimental allergic encephalomyelitis. Journal of Neuroimmunology 21: 241-248.
42. Stoll G and Jander S, 1999. The role of microglia and macrophages in the pathophysiology of the CNS. Progress in Neurobiology 58: 233-247.
43. Suen WE, Bergman CM, Hjelmstrom P and Ruddle NH, 1997. A critical role for lymphotoxin in experimental allergic encephalomyelitis. Journal of Experimental Medicine 186: 1233-1240.
44. Tuohy VK, Yu M, Yin L, Kawczak JA and Kinkel RP, 1999. Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis. Journal of Experimental Medicine 189: 1033- 1042.
45. Ufret-Vincenty RL, Quigley L, Tresser N, Pak SH, Gado A, Hausmann S, Wucherpfenning KW and Brocke S, 1998. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis. Journal of Experimental Medicine 188: 1725- 1738.
46. Weinberg AD, Whitham R, Swain SL, Morrison WJ, Wyrick G, Hoy C, Vandenbark AA and Offner H, 1992. Transforming growth factor 13 enhances the in vivo effect or function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis. Journal of Immunology 148:2109-2117.
47. Weinberg AD, Wallin JJ, Jones RE, Sullivan TJ, Bourdette DN, Vandenbark AA and Offner H, 1994. Target organ-specific up-regulation of the MRC Ox-40 marker and selective production of Thl lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis. Journal of Immunology 152: 4712-4721.
48. Weiner HL and Selkoe DJ, 2002. Inflammation and therapeutic vaccination in CNS diseases. Nature 420: 879-884.
49. Winer S, Astsaturov I, Cheung RK, Gunaratnam L, Kubiak V, Cortez MA, Moscarello M, O'Connor PW, McKerlie C, Becker DJ and Dosch H-M, 2001. Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis. Journal of Immunology 166: 2831-2841.
50. Zipp F, 2000. Apoptosis in multiple sclerosis. Cell and Tissue Research 301: 163-171.