Modulation of redox potential and alteration in reactivity via the peroxide shunt pathway by mutation of cytochrome P450 around the proximal heme ligand

Biochemistry

Volumn 47, Issue 16, 2008, Pages 4834-4842

  Matsumura, Hirotoshi ^a   Wakatabi, Masahiro ^a   Omi, Sayaka ^a   Ohtaki, Akashi ^a   Nakamura, Nobuhumi ^a   Yohda, Masafumi ^a   Ohno, Hiroyuki ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER CONCENTRATION; CHEMICAL POTENTIAL; CHEMICAL REACTIVITY; ENZYME ACTIVITY; EPOXIDATION; LIGANDS; REDOX REACTIONS; SUBSTITUTION REACTIONS;

HEME LIGAND; PHENYLALANINE; THERMOPHILIC CYTOCHROME P450;

PROTEINS;

ALANINE; CYSTEINE; CYTOCHROME P450; GLYCINE; HEME; HYDROGEN PEROXIDE; IRON; MUTANT PROTEIN; OXYGEN; PEROXIDE; PHENYLALANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STYRENE;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; EPOXIDATION; MUTATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SULFOLOBUS; SULFOLOBUS TOKODAII;

CYTOCHROME P-450 ENZYME SYSTEM; ENZYME STABILITY; GENE EXPRESSION; HEME; KINETICS; LIGANDS; MUTATION; OXIDATION-REDUCTION; PEROXIDES; SPECTROPHOTOMETRY; SPECTRUM ANALYSIS, RAMAN; STYRENE; SUBSTRATE SPECIFICITY; TEMPERATURE;

CRENARCHAEOTA; SULFOLOBUS TOKODAII STR. 7;

EID: 42449141125     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800142v     Document Type: Article

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