Gq-dependent signalling by the lysophosphatidic acid receptor LPA3 in gastric smooth muscle: Reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-indenendent PKA

Biochemical Journal

Volumn 411, Issue 3, 2008, Pages 543-551

  Sriwai, Wimolpak ^a   Zhou, Huiping ^a   Murthy, Karnam S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Gastric muscle; Muscle contraction; Myosin light chain; Nuclear factor B (NF B) signalling; Protein kinase C (PKC)

Indexed keywords

ENZYMES; LIPIDS; MUSCLE; PHOSPHORYLATION;

GASTRIC MUSCLE; MUSCLE CONTRACTION; MYOSIN LIGHT CHAIN; PROTEIN KINASE C (PKC);

ORGANIC ACIDS;

1 (5 CHLORO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; BISINDOLYLMALEIMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSOPHOSPHATIDIC ACID RECEPTOR; MYOSIN II; PHOSPHOLIPASE C; PROTEIN KINASE C; RHO KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LIPOPOLYSACCHARIDE; MYOSIN; MYOSIN LIGHT CHAIN PHOSPHATASE; PHOSPHOLIPASE C BETA; PHOSPHOTHREONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DEGRADATION; ENZYME ACTIVATION; ENZYME ACTIVITY; LIGHT CHAIN; MUSCLE CONTRACTION; MUTANT; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH MUSCLE; ANIMAL; CELL CULTURE; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MOUSE; RABBIT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

ANIMALS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; LIPOPOLYSACCHARIDES; MICE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOSIN-LIGHT-CHAIN PHOSPHATASE; MYOSINS; NF-KAPPA B; PHOSPHOLIPASE C BETA; PHOSPHORYLATION; PHOSPHOTHREONINE; RABBITS; RECEPTORS, LYSOPHOSPHATIDIC ACID; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 42449127896     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071299     Document Type: Article

References (43)

1. Anliker, B. and Chun, J. (2004) Lysophospholipid G protein-coupled receptors. J. Biol. Chem. 279, 20555-20558
2. Fukushima, N., Ishii, I., Contos, J. J., Weiner, J. A. and Chun, J. (2001) Lysophospholipid receptors. Annu. Rev. Pharmacol. Toxicol. 41, 507-534
3. Ishii, I., Fukushima, N., Ye, X. and Chun, J. (2004) Lysophospholipid receptors: signaling and biology. Annu. Rev. Biochem. 73, 321-354
4. Gardell, S. E., Dubin, A. E. and Chun, J. (2006) Emerging medicinal roles for lysophosphoslipid signaling. Trends Mol. Med. 12, 65-75
5. Moolenaar, W. H., van Meeteren, L. A. and Giepmans, B. N. (2004) The ins and outs of lysophosphatidic acid signaling. BioEssays 26, 870-881
6. 20 phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. Biochem. J. 374, 145-155
7. Bandoh, K., Aoki, J., Hosono, H., Kobayashi, S., Kobayashi, T., Murakami-Murofushi, K., Tsujimoto, M., Arai, H. and Inoue, K. (1999) Molecular cloning and characterization of a novel human G protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274, 27776-27785
8. Bandoh, K., Aoki, J., Taira, A., Tsujimoto, M., Arai, H. and Inoue, K. (2000) Lysophosphatidic acid receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. FEBS Lett. 478, 159-165
9. Chun, J., Goetzl, E. J., Hla, T., Igarashi, Y., Lynch, K. R., Moolenaar, W., Pyne, S. and Tigyi, G. (2002) International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54, 265-269
10. Noguchi, K., Ishii, S. and Shimizu, T. (2003) Identification of p2y9/GPR23 as a novel G-protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. 278, 25600-25606
11. Lee, C. W., Rivera, R., Gardell, S., Dubin, A. E. and Chun, J. (2006) GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J. Biol. Chem. 281, 23589-23597
12. Ishii, I., Contos, J. J., Fukushima, N. and Chun, J. (2000) Functional comparisons of the lysophosphatidic acid receptors, LPA1, V2G-1/EDG-2, LPA2/EDG4, and LPA3/EDG7 in neuronal cell lines using a retrovirus expression system. Mol. Pharmacol. 58, 895-902
13. Radeff-Huang, J., Seasholtz, T. M., Matteo, R. G. and Brown, J. H. (2004) G-protein-mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J. Cell. Biochem. 92, 949-966
14. Contos, J. J., Ishii, I., Fukushima, N., Kingsbury, M. A., Ye, X., Kawamura, S., Brown, J. H. and Chun, J. (2002) Characterization of lpa2(EDG4) and lpa1/lpa2 (EDG2/EDG4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa2. Mol. Cell. Biol. 22, 6921-6929
15. Ye, X., Ishii, I., Kingsbury, M. A. and Chun, J. (2002) Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim. Biophys. Acta 1585, 108-113
16. Yang, A. H., Ishii, I. and Chun, J. (2002) In vivo roles of lysophosphatidic receptors revealed by gene targeting studies in mice. Biochim. Biophys. Acta 1582, 197-203
17. Toews, M. L., Ustinova, E. E. and Schultz, H. D. (1997) Lysophosphatidic acid enhances contractility of isolated airway smooth muscle. J. Appl. Physiol. 83, 1216-1222
18. Parizi, M., Howard, E. W. and Tomasek, J. J. (2000) Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase. Exp. Cell Res. 254, 210-220
19. 2+ response via activation of phospholipase C and tyrosine kinase in cultured smooth muscle cells. Life Sci. 60, 1287-1295
20. Mori, M. and Tsushima, H. (2000) Activation of Rho signaling contributes to lysophosphatidic acid-induced contraction of intact ileal smooth muscle of guinea pig. Can. J. Physiol. Pharmacol. 78, 729-736
21. Gogarten, W., Emala, C. W., Lindeman, K. S. and Hirshman, C. A. (2001) Oxytocin and lysophosphatidic acid induces stress fiber formation in human myometrial cells via a pathway involving Rho kinase. Biol. Reprod. 65, 401-406
22. Murthy, K. S., Zhou, H., Grider, J. R. and Makhlouf, G. M. (2001) Sequential activation of heterotrimeric and monomeric G proteins mediates PLD activity in smooth muscle. Am. J. Physiol. Gastrointest. Liver Physiol. 280, G381-G388
23. Zhou, H., Das, S. and Murthy, K. S. (2003) Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of CPLA2 by m3 and m2 receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G472-G480
24. Zhou, H. and Murthy, K. S. (2004) Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. Am. J. Physiol. Cell Physiol. 286, C1130-C1138
25. Huang, J., Zhou, H., Mahavadi, S., Sriwai, W., Lyall, V. and Murthy, K. S. (2005) Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G23-G31
26. Gilchrist, A., Vanhauwe, J. F., Li, A., Thomas, T. O., Voyno-Yasenetskaya, T. and Hamm, H. E. (2001) Gα minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation. J. Biol. Chem. 276, 25672-25679
27. Gilchrist, A., Li, A. and Hamm, H. E. (2002) Design and use of C-terminal minigene vectors for studying role of heterotrimeric G proteins. Methods Enzymol. 344, 58-69
28. Hersch, E., Huang, J., Grider, J. R. and Murthy, K. S. (2004) Gq/G13 signaling by ET-1 in smooth muscle: MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB. Am. J. Physiol. Cell Physiol. 287, C1209-C1218
29. Jiang, H., Colbran, J. L., Francis, S. H. and Corbin, J. D. (1992) Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries. J. Biol. Chem. 267, 1015-1019
30. Murthy, K. S. and Makhlouf, G. M. (1995) Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells Am. J. Physiol. 268, C171-C180
31. Huang, J., Mahavadi, S., Sriwai, W., Hu, W. and Murthy, K. S. (2006) Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI 3K/ILK pathway. Biochem. J. 396, 193-200
32. Murthy, K. S. and Makhlouf, G. M. (1995) Adenosine A1 receptor-mediated activation of phospholipase Cβ-3 in intestinal muscle: dual requirement for α and βγ subunits of Gi3. Mol. Pharmacol. 47, 1172-1179
33. Murthy, K. S. and Makhlouf, G. M. (1995) Agonist-mediated activation of phosphatidylcholine-specific phospholipase C and D in intestinal smooth muscle. Mol. Pharmacol. 48, 293-304
34. 2+ mediated by distinct PKC isozymes. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G201-G210
35. Profirovic, J., Gorovoy, M., Niu, J., Pavlovic, S. and Voyno-Yasenetskaya, T. A. (2005) A novel mechanism of G protein-dependent phosphorylation of vasodilator-stimulated phosphoprotein. J. Biol. Chem. 280, 32866-32876
36. Wooldridge, A. A., MacDonald, J. A., Erdodi, F., Ma, C., Borman, M. A., Hartshorne, D. J. and Haystead, T. A. (2004) Smooth muscle phosphatase is regulated by in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of serine 695 in response to cyclic nucleotides. J. Biol. Chem. 279, 34496-34504
37. Murthy, K. S. (2006) Signaling for contraction and relaxation in smooth muscle of the gut. Annu. Rev. Physiol. 68, 345-374
38. Kitazawa, T., Eto, M., Woodsome, T. P. and Brautigan, D. L. (2000) Agonist trigger G-protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J. Biol. Chem. 275, 9897-9900
39. 2+ sensitization of myosin phosphorylation and force in guinea pig ileum. J. Physiol. 522, 33-49
40. Walsh, M. P., Susnjar, M., Deng, J., Sutherland, C., Kiss, E. and Wilson, D. P. (2007) Phosphorylation of the protein phosphatase type 1 inhibitor protein CPI-17 by protein kinase C. Methods Mol. Biol. 365, 209-223
41. Niiro, N., Koga, Y. and Ikebe, M. (2003) Agonist-induced changes in the phosphorylation of the myosin-binding subunit of myosin light chain phosphatase and CPI-17, two regulatory factors of myosin light chain phosphatase, in smooth muscle. Biochem. J. 369, 117-128
42. Deng, J. T., Sutherland, C., Brautigan, D. L., Eto, M. and Walsh, M. P. (2002) Phosphorylation of the myosin phosphatase inhibitor, CPI-17 and PHI-1, by integrin-linked kinase. Biochem. J. 367, 517-524
43. 3R-1 in vivo by cGMP-dependent protein kinase in smooth muscle. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G221-G230