Autism: A novel form of mercury poisoning

Medical Hypotheses

Volumn 56, Issue 4, 2001, Pages 462-471

  Bernard, S ^a   Enayati, A ^a   Redwood, L ^a   Roger, H ^a   Binstock, T ^a  

^a ARC Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MERCURY; THIOMERSAL;

ARTICLE; AUTISM; CLINICAL FEATURE; COMMUNICATION DISORDER; COMPULSION; GENETIC PREDISPOSITION; HEREDITY; HUMAN RELATION; MERCURIALISM; PRIORITY JOURNAL;

EID: 0035036069     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.2000.1281     Document Type: Article

References (181)

1. The screening and diagnosis of autistic spectrum disorders
2. Autism: Towards an integration of clinical, genetic, neuro-psychological, and neurobiological perspectives
3. Metabolic fate of ethylmercury salts in man and animal
4. Perspective on the use of thimerosal-containing vaccines
5. The neurotoxicity of alkyl mercury compounds
6. Mercury toxicity in the pregnant woman, fetus, and newborn infant
7. Acrodynia and mercury
8. Risperidone in adults with autism or pervasive developmental disorder
9. Clonidine treatment of hyperactive and impulsive children with autistic disorder
10. Psychiatric disorder and the broad autism phenotype: Evidence from a family study of multiple-incidence autism families
11. The diagnosis of affective and psychotic disorders in adults with autism: Seven case reports
12. Comorbid anxiety symptoms in children with pervasive developmental disorders
13. Syndromes of autism and atypical development
14. Psychiatric manifestions of mercury poisoning
15. Mercury poisoning and its treatment with N-acetyl-D., L-penicillamine
16. Magnetic resonance imaging (MRI), neurobehavioral testing, and toxic encephalopathy: Two cases
17. The neuropsychiatric sequelae of mercury poisoning: The Mad Hatters disease revisited
18. Grand rounds: Elemental mercury poisoning
19. Intra-uterine methylmercury poisoning in Iraq
20. Prenatal methylmercury poisoning
21. Mercurialism: Environmental and occupational aspects
22. Mental Effects of Mercury Poisoning
23. Mercury poisoning associated with high-dose hepatitis-B immune globulin administration after liver transplantation for chronic hepatitis B
24. The toxicology of mercury
25. Behavior of some psychological parameters of a population of a Hg extraction plant
26. The involuntary movements of chronic mercury poisoning
27. Mercury vapour intoxication
28. Mercury intoxication simulating amyotrophic lateral sclerosis
29. Behavioural and neurochemical changes in offspring of rats exposed to methylmercury during gestation
30. Testing strategies in behavioral teratology. III. Microanalysis of behavior
31. Brief report: Neuropsychology of autism: A report on the state of the science
32. Alkyl mercury poisoning in humans
33. Cognitive performance of children prenatally exposed to "safe" levels of methylmercury
34. Methylmercury poisoning in Iraqi children: Clinical observations over two years
35. Mercury: Major issues in environmental health
36. The differentiation between autism and Asperger syndrome
37. Movement analysis in infancy may be useful for early diagnosis of autism
38. Brief report: Comorbid psychiatric disorders of autistic disorder
39. Exploring the experience of autism through firsthand accounts
40. Movements in autistic disorder
41. Autism and hearing loss
42. Behavior profiles within a population of 145 children with autism using the Behaviour Summarized Evaluation scale: Influence of developmental age
43. Autism during infancy: A retrospective video analysis of sensory-motor and social behaviors and 9-12 months of age
44. Sensory-perceptual abnormalities in autism: A case for more research?
45. Family and personal section: From the inside out - A view of the world as seen by one with Asperger syndrome
46. Visual impairment and autism: Current questions and future research
47. Brief report: Brain mechanisms in autism: Functional and structural abnormalities
48. Expression of a neural cell adhesion molecule serum fragment is depressed in autism
49. Cellular resistance to methylmercury
50. Health effects of mercury and mercury compounds
51. Mercury vapor inhalation inhibits binding of GTP to tubulin in rat brain: Similarity to a molecular lesion in Alzheimer diseased brain
52. Developmental methymercury administration alters cerebellar PSA-NCAM expression and Golgi sialyltransferase activity
53. More evidence links autism, cerebellar defects
54. Lower Purkinje cell counts in the cerebella of four autistic subjects: Intitial findings of the UCLA-NSAC Autopsy Research Report
55. The mesial-temporal lobe and autism: Case report and review
56. Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism
57. The neuroanatomy of autism: A voxel-based whole brain analysis of structural scans
58. MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults
59. Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: An 1H-MR spectroscopy study
60. An MRI study of the basal ganglia in autism
61. Development of the brainstem and cerebellum in autistic patients
62. A neurophysiological study of autistic children
63. Methylmercury poisoning: Long term clinical, radiological, toxicological, and pathological studies of an affected family
64. Methylmercury induced alterations in the nerve growth factor level in the developing brain
65. Mercury exposure from "silver" tooth fillings: Emerging evidence questions a traditional dental paradigm
66. The comparative toxicology of ethyl-and methylmercury
67. Memory systems in the brain
68. Medial temporal lobe structures: A review of clinical and experimental findings
69. Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children
70. Autism: Review of neurochemical investigation
71. Methylmercury-induced movement and postural disorders in developing rat: Regional analysis of brain catecholamines and indoleamines
72. Effects of thimerosal, an organic sulfhydryl modifying agent, on serotonin transport activity into rabbit blood platelets
73. Effects of mercury compounds on the spontaneous and potassium-evoked release of [3H]dopamine from mouse striatal slices
74. Effects of chronic exposure to cadmium, lead and mercury of brain biogenic amines in the rat
75. Clinical heterogeneity of the autistic syndrome: A study of 60 families
76. Lewine magnetoenchalography in children with an autistic epileptiform regression
77. Autism and autistic epileptiform regression with occipital spikes
78. Late EEG finding and clinical status after organic mercury poisoning
79. EEG findings in chlor-alkali workers subject to low long term exposure to mercury vapor
80. Mercury toxicity following merthiolate ear irrigations
81. Chronic low-dose maternal exposure to methylmercury enhances epileptogenicity in developing rats
82. Involvement of glutamate in human epileptic activities
83. Enzyme and sulfur oxidation deficiencies in autistic children with known food/chemical intolerances
84. Sulphation deficit in "low-functioning" autistic children: A pilot study
85. Renal Na-Si cotransporter NaSi-1 is inhibited by heavy metals
86. Alterations in two enzymes: Superoxide dismutase and glutathion peroxidase in developmental infantile psychosis
87. Autism: Xenobiotic influences
88. In vivo effects of Mercury (II) on deoxyuridine triphosphate nucleotidohydrolase, DNA polymerase (α, β), uracil-DNA glycosylase activities in cultured human cells: Relationship to DNA damage, DNA repair, and cytotoxicity
89. Decreased levels of total and reduced glutathione in CD4+ lymphocytes in common variable immunodeficiency are associated with activation of the tumor necrosis factor system: Possible immunopathogenic role of oxidative stress
90. Functional abnormalities of CD8+ t cells define a unique subset of patients with common variable immunodeficiency
91. Low-level methylmercury exposure causes human T-cells to undergo apoptosis: Evidence of mitochondrial dysfunction
92. Developmental disorder associated with increased cellular nucleotidase activity
93. Purine metabolism abnormalities in a hyperuricosuric subclass of autism
94. Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders
95. Antibodies to myelin basic protein in children with autistic behavior
96. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism
97. Clinical features associated with autism: Observations of symptoms outside the diagnostic boundaries of autistic spectrum disorders
98. Immune abnormalities in patients with autism
99. Immunological aspects of autism
100. Abnormal immune response to brain tissue antigen in the syndrome of autism
101. Experimental studies on genetically determined susceptibility to mercury-induced autoimmune response
102. Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-responders and a shift of the interleukin profile
103. Mercury induces polyclonal B cell activation, autoantibody production and renal immune complex deposits in young (NZB × NZW) F1 hybrids
104. Reduced natural killer cell activity in autism
105. Brief report: Dysregulated immune system in children with autism: Beneficial effects of intravenous immune globulin on autistic characteristics
106. Urinary levels of neopterin and biopterin in autism
107. The genotype determines the B cell response in mercury-treated mice
108. Murine mercury-induced autoimmunity: A model of chemically related autoimmunity in humans
109. Mechanism of mercury-induced autoimmunity: Both T helper 1- and T helper 2-type responses are involved
110. Effects of methyl mercury exposure on spleen and blood natural-killer (NK) cell-activity in the mouse
111. Early effects of methylmercury on the visual evoked response of the dog
112. Autistic disturbances of affective contact
113. Autism: Not an extremely rare disorder
114. State of the science in autism: Report to the National Institutes of Health
115. Persistent differential alteration in developing cerebellar cortex of male and female mice after methylmercury exposure
116. Prenatal exposure to methylmercury alters locomotor activity of male but not female rats
117. Uproar over a little-known preservative, thimerosal, jostles U.S. hepatitis B vaccination policy
118. Conversational abilities among children with autism and children with developmental delays
119. Behavioural and emotional disturbance in high-functioning autism and Aspergers syndrome
120. Alertness to neuropsychiatric manifestations
121. Outcome in adult life for more able individuals with autism or Asperger syndrome
122. A normed study of face recognition in autism and related disorders
123. Autism: New data suggest a new hypothesis
124. An evaluation of early development in children with autism and pervasive developmental disorders from home movies: Preliminary findings
125. Can autism be detected at 18 months: The needle, the haystack, and the CHAT
126. Delayed language onset as a predictor of clinical symptoms in pervasive developmental disorders
127. Brief report: Communication, language, social, and emotional development
128. The learning style of people with autism: An autobiography
129. Chronic elemental mercury intoxication: Neuropsychological follow up case study
130. Acute and chronic neuropsychological consequences of mercury vapor poisoning in two early adolescents
131. Mercury poisoning in children
132. Enhancement of ovalbumin-induced antibody production and mucosal mast cell response by mercury
133. The high functioning autistic experience: Birth to preteen years
134. Abnormal intestinal permeability in children with autism
135. Gastrointestinal abnormalities in children with autistic disorder
136. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
137. Factors predicting intelligence cores on the TONI in individuals with autism
138. Long term follow-up early intervention effects lasting
139. Conceptual problem-solving in highly verbal, nonretarded autistic men
140. Anatomy of self-injurious, stereotypic, and aggressive movements: Evidence for involuntary explanation
141. The prevalence of anxiety and mood problems among children with autism and Asperger syndrome
142. Sleep problems in autism: Prevalence, cause, and intervention
143. Abnormal sleeping patterns associated with autism: A brief review of research findings, assessment methods and treatment strategies
144. Altered patterns of protein phosphorylation and synthesis caused by methyl mercury in cerebellar granule cell culture
145. Low levels of ionic mercury modulate protein tyrosine phosphorylation in lymphocytes
146. Influence of mercury on uptake of [3H]dopamine and [3H]norepinephrine by rat brain synaptosomes
147. Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures
148. The mechanism of methyl mercury toxicity in isolated rat hepatocytes
149. Mechanisms of methylmercury-induced neurotoxicity
150. Acute administration of methylmercury changes in vivo dopamine release from rat striatum
151. Neuroimmunotoxicology: Humoral assessment of neurotoxicity and autoimmune mechanisms
152. Effects of inorganic and organic mercury on intracellular calcium levels in rat T lymphocytes
153. Thimerosal: A versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent
154. Irreversible suppression of calcium entry into nerve terminals by methylmercury
155. Chronic inorganic mercury induced peripheral neuropathy
156. Low-level exposure to methylmercury modifies muscarinic cholinergic receptor binding characteristics in rat brain and lymphocytes: Physiologic implications and new opportunities in biologic monitoring
157. High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes
158. Autism: A mitochondrial disorder?
159. Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism
160. Plasma increase of Interleuken-12 and Interferon-gamma. Pathological significance in autism
161. Microcephaly and macrocephaly in autism
162. Hypothesis: Is infantile autism a hypoglutamatergic disorder? Relevance of glutamate - Serotonin interactions for pharmacotherapy
163. CSF monoamines in autistic syndromes and other pervasive dev. disorders of early childhood
164. Low medial prefrontal dopaminergic activity in autistic children
165. Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives
166. Neurophysiologic studies of infantile autism
167. Thinking in autism: Differences in learning and development