Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarb oxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4359-4366

  Sakagami, Kazunari ^a   Yasuhara, Akito ^a   Chaki, Shigeyuki ^a   Yoshikawa, Ryoko ^a   Kawakita, Yasunori ^a   Saito, Akio ^b   Taguchi, Takeo ^b   Nakazato, Atsuro ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Antagonist; Fluorinated compound; Group II mGluRs; Prodrug

Indexed keywords

2 [1 AMINO 1 CARBOXY 2 (9H XANTHEN 9 YL)ETHYL] 1 FLUOROCYCLOPROPANECARBOXYLIC ACID; 2 [1 AMINO 1 CARBOXY 2 (9H XANTHEN 9 YL)ETHYL] 1 FLUOROCYCLOPROPANECARBOXYLIC ACID HEPTYL ESTER; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CYCLOPROPANATION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINATION; IN VITRO STUDY; MALE; NONHUMAN; RAT; STEREOCHEMISTRY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; LIVER; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PRODRUGS; PROTEIN BINDING; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHENES;

EID: 42249112404     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.066     Document Type: Article

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