Synthesis, in vitro pharmacology, and structure-activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3405-3420

  Yasuhara, Akito ^a   Sakagami, Kazunari ^a   Yoshikawa, Ryoko ^a   Chaki, Shigeyuki ^a   Nakamura, Masato ^a   Nakazato, Atsuro ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

2 Aminobicyclo 3.1.0 hexane 2,6 dicarboxylic acids; mGluR2 antagonist; Structure activity relationship; Synthesis

Indexed keywords

2 AMINO 3 (3,4 DICHLOROBENZYLTHIO) 6 FLUOROBICYCLO[3.1.0] 2,6 CARBOXYLIC ACID; 2 AMINO 3 [N (3,4 DICHLOROBENZYLAMINO)] 6 FLUOROBICYCLO[3.1.0]HEXANE 2,6 CARBOXYLIC ACID; 3 (3,4 DICHLOROBENZYLOXY) 2 AMINOBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID; 3 ALKOXY 2 AMINOBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID; 3 BENZYLAMINO 2 AMINO 6 FLUOROBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID; 3 BENZYLTHIO 2 AMINO 6 FLUOROBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; DICARBOXYLIC ACID DERIVATIVE; EGLUMETAD; METABOTROPIC RECEPTOR 2 ANTAGONIST; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG SYNTHESIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ANXIETY AGENTS; BICYCLO COMPOUNDS; BINDING, COMPETITIVE; CELL LINE; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MOLECULAR STRUCTURE; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33645930970     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.061     Document Type: Article

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