Electrochemotherapy: An emerging cancer treatment

International Journal of Hyperthermia

Volumn 24, Issue 3, 2008, Pages 263-273

  Sadadcharam, Mira ^a   Soden, Declan M ^a   O'Sullivan, Gerald C ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Breast cancer; Cancer therapies; Chemotherapy; Electroporation; Head and neck cancer; Melanoma

Indexed keywords

BLEOMYCIN; CISPLATIN; INTERLEUKIN 2; NAKED DNA;

ANESTHESIA INDUCTION; BREAST CARCINOMA; CANCER GENE THERAPY; CANCER IMMUNOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER STAGING; CELL MEMBRANE PERMEABILITY; CLINICAL PRACTICE; CLINICAL TRIAL; CYTOTOXICITY; DRUG EFFICACY; ELECTROCHEMOTHERAPY; ELECTRODE; ELECTROPORATION; EQUIPMENT DESIGN; FIBROSARCOMA; FOLLOW UP; GLIOMA; HEAD AND NECK CANCER; HISTOPATHOLOGY; HUMAN; HYDROPHILICITY; LIVER CELL CARCINOMA; LUNG CARCINOMA; MALIGNANT NEOPLASTIC DISEASE; MEDICAL RESEARCH; MELANOMA; METASTASIS POTENTIAL; MINIMAL RESIDUAL DISEASE; NONVIRAL GENE DELIVERY SYSTEM; OUTCOME ASSESSMENT; PATIENT SAFETY; PULSE GENERATOR; REPRODUCIBILITY; REVIEW; SKIN CANCER; TREATMENT OUTCOME; TUMOR VOLUME;

ANTINEOPLASTIC AGENTS; ELECTROCHEMOTHERAPY; HUMANS; NEOADJUVANT THERAPY; NEOPLASMS;

EID: 42049120356     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.1080/02656730701832334     Document Type: Review

References (60)

1. Mir, LM, Orlowski, S., Belehradek Jr, J. and Paoletti, C. (1991) Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur J Cancer, 27, pp. 68-72.
2. Belehradek Jr, J., Orlowski, S., Poddevin, B. and Paoletti, C. (1991) Electrochemotherapy of spontaneous mammary tumours in mice. Eur J Cancer, 27, pp. 73-76.
3. Heller, R., Gilbert, R. and Jaroszeski, MJ (1997) Electrochemotherapy: An emerging drug delivery method for the treatment of cancer. Adv Drug Deliv Rev, 26, pp. 185-197.
4. Belehradek, M., Domenge, C., Luboinski, B., Orlowski, S., Belehradek Jr, J. and Mir, LM (1993) Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer, 72, pp. 3694-3700.
5. Heller, R., Gilbert, R. and Jaroszeski, MJ (1999) Clinical applications of electrochemotherapy. Adv Drug Deliv Rev, 35, pp. 119-129.
6. Weaver, JC (1995) Electroporation theory. Concepts and mechanisms. Methods Mol Biol, 55, pp. 3-28.
7. Teissie, J., Eynard, N., Vernhes, MC, Benichou, A., Ganeva, V., Galutzov, B. and Cabanes, PA (2002) Recent biotechnological developments of electropulsation. A prospective review. Bioelectrochemistry, 55, pp. 107-112.
8. Orlowski, S., Belehradek, J., Paoletti, C. and Mir, LM (1988) Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs. Biochem Pharmacol, 37, pp. 4727-4733.
9. Gehl, J., Skovsgaard, T. and Mir, LM (1998) Enhancement of cytotoxicity by electropermeabilization: An improved method for screening drugs. Anticancer Drugs, 9, pp. 319-325.
10. Mir, LM (1991) [Electrochemotherapy, a new antitumor treatment: First clinical trial]. C R Acad Sci III, 313, pp. 613-618.
11. (1998) Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer, 77, pp. 2336-2342.
12. Heller, R., Jaroszeski, M., Perrott, R., Messina, J. and Gilbert, R. (1997) Effective treatment of B16 melanoma by direct delivery of bleomycin using electrochemotherapy. Melanoma Res, 7, pp. 10-18.
13. Sersa, G., Stabuc, B., Cemazar, M., Miklavcic, D. and Rudolf, Z. (2000) Electrochemotherapy with cisplatin: Clinical experience in malignant melanoma patients. Clin Cancer Res, 6, pp. 863-867.
14. Bloom, DC and Goldfarb, PM (2005) The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck. Eur J Surg Oncol, 31, pp. 1029-1035.
15. Heller, R., Jaroszeski, M., Atkin, A., Moradpour, D., Gilbert, R., Wands, J. and Nicolau, C. (1996) In vivo gene electroinjection and expression in rat liver. FEBS Lett, 389, pp. 225-228.
16. Rols, MP, Delteil, C., Golzio, M., Dumond, P., Cros, S. and Teissie, J. (1998) In vivo electrically mediated protein and gene transfer in murine melanoma. Nat Biotechnol, 16, pp. 168-171.
17. Gehl, J. (2003) Electroporation theory and methods perspectives for drug delivery, gene therapy and research. Acta Physiol Scand, 177, pp. 437-447.
18. Kranjc, S., Camazar, M., Grosel, A. and Sentjurc, Sersa G. (2005) Radiosensitising effect of electrochemotherapy with bleomycin LPB sarcoma cells and tumors in mice. BMC Cancer, 5, p. 115.
19. Sersa, G., Stabuc, B., Camazar, M., Miklavcic, D. and Rudolf, Z. (2000) Electrochemotherapy with cisplatin: The systemic antitumour effectiveness of cisplatin can be potentiated locally by the application of electric pulses in the treatment of malignant melanoma skin metastases. Melanoma Res, 10, pp. 381-385.
20. Larkin, J., Collins, C., Aarons, S., Tangney, M., Whelan, M., O'Reily, S., Breathnach, O., Soden, D. and O'Sullivan, G. (2007) Electrochemotherapy aspects of preclinical development and early clinical experience. Annals Surg, 245, pp. 469-479.
21. Soden, D., Larkin, J., Collins, C., Tangney, M., Aarons, S., Piggott, J., Morrissey, A., Dunne, C. and O'Sullivan, G. (2005) Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumours. Cancer Letters, 232, pp. 300-310.
22. Chang, DC and Reese, TS (1990) Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy. Biophys J, 58, pp. 1-12.
23. Lopez, A., Rols, MP and Teissie, J. (1988) 31P NMR analysis of membrane phospholipid organization in viable, reversibly electropermeabilized Chinese hamster ovary cells. Biochemistry, 27, pp. 1222-1228.
24. Mir, LM, Banoun, H. and Paoletti, C. (1988) Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: Direct access to the cytosol. Exp Cell Res, 175, pp. 15-25.
25. Engstrom, PE, Persson, BR and Salford, LG (1999) Studies of in vivo electropermeabilization by gamma camera measurements of (99 m)Tc-DTPA. Biochim Biophys Acta, 1473, pp. 321-328.
26. Belehradek Jr, J., Orlowski, S., Ramirez, LH, Pron, G., Poddevin, B. and Mir, LM (1994) Electropermeabilization of cells in tissues assessed by the qualitative and quantitative electroloading of bleomycin. Biochim Biophys Acta, 1190, pp. 155-163.
27. Jaroszeski, MJ, Dang, V., Pottinger, C., Hickey, J., Gilbert, R. and Heller, R. (2000) Toxicity of anticancer agents mediated by electroporation in vitro. Anticancer Drugs, 11, pp. 201-208.
28. Kotnik, T. and Miklavcic, D. (2000) Analytical description of transmembrane voltage induced by electric fields on spheroidal cells. Biophys J, 79, pp. 670-679.
29. Hibino, M., Shigemori, M., Itoh, H., Nagayama, K. and Kinosita, Jr K. (1991) Membrane conductance of an electroporated cell analyzed by submicrosecond imaging of transmembrane potential. Biophys J, 59, pp. 209-220.
30. Teissie, J. and Rols, MP (1993) An experimental evaluation of the critical potential difference inducing cell membrane electropermeabilization. Biophys J, 65, pp. 409-413.
31. Gabriel, B. and Teissie, J. (1997) Direct observation in the millisecond time range of fluorescent molecule asymmetrical interaction with the electropermeabilized cell membrane. Biophys J, 73, pp. 2630-2637.
32. Schwister, K. and Deuticke, B. (1985) Formation and properties of aqueous leaks induced in human erythrocytes by electrical breakdown. Biochim Biophys Acta, 816:2, pp. 332-348.
33. Gabriel, B. and Teissie, J. (1999) Time courses of mammalian cell electropermeabilization observed by millisecond imaging of membrane property changes during the pulse. Biophys J, 76, pp. 2158-2165.
34. Mir, LM and Orlowski, S. (1999) Mechanisms of electrochemotherapy. Adv Drug Deliv Rev, 35, pp. 107-118.
35. Mir, LM (2006) Bases and rationale of the electrochemotherapy. Eur J Cancer, 4, pp. 38-44.
36. Marty, M., Sersa, G., Garbay, JR, Gehl, J., Collins, CG, Snoj, M., Billard, V., Geertsen, PF, Larkin, JO and Miklavcic, D. (2006) Electrochemotherapy: An easy highly effective and safe treatment of cutaneous and subcutaneous metastases. Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer, 4, pp. 3-13.
37. Ramirez, LH, Orlowski, S., An, D., Bindoula, G., Dzodic, R., Ardovin, P., Bognel, C., Belehradek, Jr J., Munck, JN and Mir, LM (1998) Electrochemotherapy on liver tumours in rabbits. Br J Cancer, 77, pp. 2104-2111.
38. Mir, LM (2001) Therapeutic perspectives of in vivo cell electropermeabilization. Bioelectrochemistry, 53, pp. 1-10.
39. Gehl, J., Skovsgaard, T. and Mir, LM (2002) Vascular reactions to in vivo electroporation: Characterization and consequences for drug and gene delivery. Biochim Biophys Acta, 569, pp. 51-58.
40. Engstrom, PE, Persson, BR, Bron, A. and Salford, LG (2001) A new antitumour treatment combining radiation and electric pulses. Anticancer Res, 21, pp. 1809-1815.
41. Sersa, G., Cemazar, M., Miklavcic, D. and Chaplin, DJ (1999) Tumor blood flow modifying effect of electrochemotherapy with bleomycin. Anticancer Res, 19, pp. 4017-4022.
42. Mitchell, MS (1988) Combining chemotherapy with biological response modifiers in treatment of cancer. J Natl Cancer Inst, 80, pp. 1445-1450.
43. Mir, LM, Tounekti, O. and Orlowski, S. (1996) Bleomycin: Revival of an old drug. Gen Pharmacol, 27, pp. 745-748.
44. Tounekti, O. and Belehradek Jr, PG (1993) Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized. Cancer Res, 53, pp. 5462-5469.
45. Pron, G., Mahrour, N., Orlowski, S., Tounekti, O., Poddevin, B., Belehradek, J. and Mir, LM (1999) Internalisation of the bleomycin molecules responsible for bleomycin toxicity: A receptor-mediated endocytosis mechanism. Biochem Pharmacol, 57, pp. 45-56.
46. Poddevin, B. and Belehradek Jr, OS (1991) Very high cytotoxicity of bleomycin introduced into the cytosol of cells in culture. Biochem Pharmacol, 42, pp. S67-S75.
47. Tounekti, KA O. and Foray, N. (2001) The ratio of single- to double-stranded DNA breaks and their absolute values determine cell death pathway. Br J Cancer, 84, pp. 1272-1279.
48. Okino, M., Tomie, H., Kanesada, H., Marumoto, M., Esata, K. and Suzuki, H. (1992) Optimal electric conditions in electrical impulse chemotherapy. Jpn J Cancer Res, 83, pp. 1095-1101.
49. Heller, MJ R., Leo-Messina, J., Perrott, R., Van Voorhis, N. and Reintgen, D. (1995) Treatment of B16 melanoma with the combination of electroporation and chemotherapy. Bioelectrochemistry, 36, pp. 83-87.
50. Gately, DP and Howell, SB (1993) Cellular accumulation of the anticancer agent cisplatin: A review. Br J Cancer, 67, pp. 1171-1176.
51. JE, EOP Melvik, Gordon, PB and Seglen, PO (1986) Increase in cis-dichloroammineplatinum (II) cytotoxicity upon reversible electropermeabilization of the plasma membrane in cultured human NHIK 3025 cells. Eur J Cancer, 22, pp. 1523-1530.
52. Sersa, MC G. and Miklavcic, D. (1995) Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum (II) in mice. Cancer Res, 55, pp. 3450-3455.
53. Mir, LM, Gehl, J., Sersa, G., Sersa, G., Collins, CE, Garbay, JR, Billard, V., Geertsen, PF, Rudolf, Z. and O'Sullivan, GC (2006) Standard operating procedures for electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator by means of invasive or non-invasive electrodes. Eur J Cancer, 4, pp. 14-25.
54. Domenge, C., Orlowski, S., Luboinski, M., De Baere, T., Schwaab, G., Belehradek, Jr J. and Mir, LM (1996) Antitumor electrochemotherapy: New advances in the clinical protocol. Cancer, 77, pp. 956-963.
55. Cemazar, M., Milacic, R., Miklavcic, D., Dolzan, V. and Sersa, G. (1998) Intratumoral cisplatin administration in electrochemotherapy: Antitumor effectiveness, sequence dependence and platinum content. Anticancer Drugs, 9, pp. 525-530.
56. Marty, M., Sersa, G., Garbay, JR, Gehl, J., Collins, GC, Snoj, M., Billard, V., Geertsen, PF, Larkin, JO and Miklavcic, D. (2006) Electrochemotherapy - An easy, highly effective and safe treatment of cutaneous and subcutaneous meastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer, 4, pp. 3-13.
57. Whelan, M., Larkin, JO, Collins, GC, Cashman, J., Breathnach, O., Soden, DM and O'Sullivan, GC (2006) Effective treatment of an extensive recurrent breast cancer which was refractory to multimodal therapy by multiple applications of electrochemotherapy. Eur J Cancer, 4, pp. 32-34.
58. Peycheva, E., Daskalov, I. and Tsoneva, I. (2007) Electrochemotherapy of mycosis fungoides by interferon alpha. Bioelectrochemistry, 70, pp. 283-286.
59. Collins, C., Tangney, M., Larkin, JO, Casey, G., Whelan, MC, Cashman, J., Murphy, J., Soden, D., Vejda, S. and McKenna, S. (2006) Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors. Cancer Gene Therapy, 13, pp. 1061-1071.
60. Heller, L., Joroszeski, MJ, Coppola, D., Pottinger, C., Gilbert, R. and Heller, R. (2000) Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo. Gene Ther, 7, pp. 826-829.