Internalisation of the bleomycin molecules responsible for bleomycin toxicity: A receptor-mediated endocytosis mechanism

Biochemical Pharmacology

Volumn 57, Issue 1, 1999, Pages 45-56

  Pron, Géraldine ^a,c   Mahrour, Nawel ^a   Orlowski, Stéphane ^b   Tounekti, Omar ^b,d   Poddevin, Bruno ^a,e   Belehradek, Jean ^a   Mir, Lluis M ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b CNRS   (France)

^c Alcimed   (France)

^d UNIVERSITY OF CARTHAGE   (Tunisia)

^e GENSET   (France)

Author keywords

Bleomycin; Drug uptake; Drug binding proteins; Electropermeabilisation; Endocytosis; Receptor mediated endocytosis

Indexed keywords

BLEOMYCIN; MEMBRANE PROTEIN; MEMBRANE RECEPTOR;

ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG DIFFUSION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG UPTAKE; ENDOCYTOSIS; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; BLEOMYCIN; CELL LINE, TRANSFORMED; CELL SURVIVAL; COBALT RADIOISOTOPES; CRICETINAE; CRICETULUS; ENDOCYTOSIS; FLUORESCENT DYES; HEAD AND NECK NEOPLASMS; HUMANS; HYDROGEN-ION CONCENTRATION; ISOQUINOLINES; KINETICS; MEMBRANE PROTEINS; POTASSIUM; TEMPERATURE; TUMOR CELLS, CULTURED;

EID: 0032923086     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00282-2     Document Type: Article

References (34)

1. Umezawa H., Maeda K., Takeuchi T., Okami Y. New antibiotics, bleomycin A and B. J Antibiot (Tokyo) Ser A. 19:1966;200-209.
2. Orlowski S., Belehradek J. Jr, Paoletti C., Mir L.M. Transient electropermeabilization of cells in culture Increase of the cytotoxicity of anticancer drugs . Biochem Pharmacol. 37:1988;4727-4733.
3. Poddevin B., Orlowski S., Belehradek J. Jr, Mir L.M. Very high cytotoxicity of bleomycin introduced into the cytosol of cells in culture. Biochem Pharmacol. 42:(S):1991;67-75.
4. Tounekti O., Pron G., Belehradek J. Jr, Mir L.M. Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized. Cancer Res. 53:1993;5462-5469.
5. Mir L.M., Tounekti O., Orlowski S. Bleomycin, revival of an old drug. Gen Pharmacol. 27:1996;745-748.
6. 2 with HeLa cells. Cancer Res. 44:1984;1541-1546.
7. Lyman S., Ujjani B., Renner K., Antholine W., Petering D.H., Whetstone J.W., Knight J.M. Properties of the initial reaction of bleomycin and several of its metal complexes with Ehrlich cells. Cancer Res. 46:1986;4472-4478.
8. Uehara Y., Hori M., Umezawa H. Specificity of transport of bleomycin and cobalt-bleomycin in L5178Y cells. Biochem Biophys Res Commun. 104:1982;416-421.
9. Pron G., Belehradek J. Jr, Mir L.M. Identification of a plasma membrane protein that specifically binds bleomycin. Biochem Biophys Res Commun. 194:1993;333-337.
10. Pron G., Belehradek J. Jr, Orlowski S., Mir L.M. Involvement of the membrane bleomycin-binding sites in the bleomycin cytotoxicity. Biochem Pharmacol. 48:1994;301-310.
11. Lazo J.S., Schisselbauer J.C., Meandzija B., Kennedy K.A. Initial single-strand DNA damage and cellular pharmacokinetics of bleomycin A. Biochem Pharmacol. 38:1989;2207-2213.
12. Morris G., Mistry J.S., Jani J.P., Sebti S.M., Lazo J.S. Cysteine proteinase inhibitors and bleomycin-sensitive and -resistant cells. Biochem Pharmacol. 41:1991;1559-1566.
13. Biedler J.L., Riehm H. Cellular resistance to actinomycin D in Chinese hamster cells in vitro Cross-resistance, radioautographic, on cytogenetic studies . Cancer Res. 30:1970;1171-1184.
14. Sandvig K., Olsnes S. Diphtheria toxin entry into cells is facilitated by low pH. J Cell Biol. 87:1980;828-832.
15. Poddevin B., Belehradek J. Jr, Mir L.M. Stable [Co]-bleomycin complex with a very high specific radioactivity for use at very low concentrations. Biochem Biophys Res Commun. 173:1990;259-264.
16. Swanson J.A., Yirinec B.D., Silverstein S.C. Phorbol esters and horseradish peroxidase stimulate pinocytosis and redirect the flow of pinocytosed fluid in macrophages. J Cell Biol. 100:1985;851-859.
17. Silverstein S.C., Steinman R.M., Cohn Z.A. Endocytosis. Annu Rev Biochem. 60:1977;669-722.
18. Dean R.T., Jessup W., Roberts C.R. Effects of exogenous amines on mammalian cells, with particular reference to membrane flow. Biochem J. 217:1984;27-40.
19. Larkin J.M., Brown M.S., Goldstein J.L., Anderson R.G.W. Depletion of intracellular potassium arrests coated pits formation and receptor-mediated endocytosis in fibroblasts. Cell. 33:1983;273-285.
20. Madshus I.H., Sandvig K., Olsnes S., Deurs B. Effect of reduced endocytosis induced by hypotonic shock and potassium depletion on the infection of Hep 2 cells by picornaviruses. J Cell Physiol. 131:1987;14-22.
21. Mir L.M., Banoun H., Paoletti C. Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization Direct access to the cytosol . Exp Cell Res. 175:1988;15-25.
22. Lazo J.S., Braun I.D., Labaree D.C., Schisselbauer J.C., Meandzija B., Newman R.A., Kennedy K.A. Characteristics of bleomycin-resistant phenotypes of human cell sublines and circumvention of bleomycin resistance by liblomycin. Cancer Res. 49:1989;185-190.
23. Lazo J.S., Schisselbauer J.C., Herring G.M., Kennedy K.A. Involvement of the cellular vacuolar system with the cytotoxicity of bleomycin-like agents. Cancer Commun. 2:1990;81-86.
24. Olsnes S., Sandvig K. Entry of polypeptide toxins into animal cells. Pastan I., Willingham M.C., Endocytosis. 1985;195-234 Plenum Publishing Corp, New York.
25. Simmons B.M., Stahl P.D., Russell J.H. Mannose receptor-mediated uptake of ricin toxin and ricin A chain by macrophages Multiple intracellular pathways for A chain translocation . J Biol Chem. 261:1986;7912-7920.
26. van Deurs B., Sandvig K., Petersen O.W., Olsnes S., Simons K., Griffiths G. Estimation of the amount of internalized ricin that reaches the trans-Golgi network. J Cell Biol. 106:1988;253-267.
27. Orlowski S., Mir L.M. Cell electropermeabilization A new tool for biochemical and pharmacological studies . Biochim Biophys Acta. 1154:1993;51-63.
28. Belehradek J. Jr, Orlowski S., Pron G., Poddevin B., Mir L.M. Electropermeabilization of cells in tissues assessed by the qualitative and quantitative electroloading of bleomycin. Biochim Biophys Acta. 1190:1994;155-163.
29. Belehradek M., Domenge C., Luboinski B., Orlowski S., Belehradek J. Jr, Mir L.M. Electrochemotherapy, a new antitumor treatment First clinical phase I-II trial . Cancer. 72:1993;3694-3700.
30. Domenge C., Orlowski S., Luboinski B., De Baere T., Schwaab G., Belehradek J. Jr, Mir L.M. Antitumor electrochemotherapy New advances in the clinical protocol . Cancer. 77:1996;956-963.
31. Heller R., Jaroszeski M.J., Glass L.F., Messina J.L., Rapaport D.P., DeConti R.C., Fenske N.A., Gilbert R.A., Mir L.M., Reintgen D.S. Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy. Cancer. 77:1996;964-971.
32. Mir L.M., Glass F.L., Serša G., Teissié J., Domenge C., Miklavčič D., Jaroszeski M.J., Orlowski S., Reintgen D.S., Rudolf Z., Belehradek M., Gilbert R., Rols M.P., Belehradek J. Jr, Bachaud J.M., DeConti R., Štabuc B., Čemažar M., Coninx P., Heller R. Effective treatment of cutaneous and subcutaneous malignant tumors by electrochemotherapy. Br J Cancer. 77:1998;2336-2342.
33. Matkhanov I.E., Galanova Y.V., Voschinnikov E.I., Archakov A.I. Cytotoxic effects of free bleomycin A5-iron (II) complex and its conjugates with concanavalin A, insulin and calcitonin on mouse thymocytes. Biochem Biophys Res Commun. 197:1993;85-91.
34. Lazo J.S., Humphreys C.J. Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity. Proc Natl Acad Sci USA. 80:1983;3064-3068.