Intratumoral cisplatin administration in electrochemotherapy: Antitumor effectiveness, sequence dependence and platinum content

Anti-Cancer Drugs

Volumn 9, Issue 6, 1998, Pages 525-530

  Čemažar, Maja ^a   Milačič, Radmila ^b   Miklavčič, Damijan ^c   Dolžan, Vita ^d   Serša, Gregor ^a  

^a INSTITUTE OF ONCOLOGY   (Slovenia)

^b JO EF STEFAN INSTITUTE   (Slovenia)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Cisplatin; Ehrlich ascites carcinoma; Electrochemotherapy; Platinum determination

Indexed keywords

CISPLATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG RESPONSE; DRUG TUMOR LEVEL; ELECTROCHEMOTHERAPY; ELECTROPORATION; EXPERIMENTAL NEOPLASM; FEMALE; INTRATUMORAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; MULTIMODALITY CANCER THERAPY; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0031870747     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199807000-00002     Document Type: Article

References (29)

1. Mir LM, Orlowski S, Belehradek J Jr, et al. Biomedical applications of electric pulses with special emphasis on antitumor electrochemotherapy. Bioelectrochem Bioener 1995; 38: 203-7.
2. Poddevin B, Orlowski S, Belehradek J Jr, et al. Very high cytotoxicity of bleomycin introduced into the cytosol of cells in culture. Biochem Pharmacol 1991; 42: S67-75.
3. Heller R, Jaroszeski M, Perrott R, et al. Effective treatment of B16 melanoma by direct delivery of bleomycin using electrochemotherapy. Melanoma Res 1997; 7: 10-8.
4. Salford LG, Persson BRR, Brun A, et al. A new brain tumour therapy combining bleomycin with in vivo electropermeabilization. Biochim Biophys Res Commun 1993; 194: 938-43.
5. Serša G. Čemažar M, Miklavčič D, et al. Electrochemotherapy: variable anti-tumor effect on different tumor models. Bioelectrochem Bioener 1994; 35: 23-7.
6. Mir IM, Roth C, Orlowski S, et al. Systemic antitumor effects of electrochemotherapy combined with histoincompatible cells secreting interleukin-2. J Immunother 1995; 17: 30-8.
7. Okino M, Tomie H, Kanesada H, et al. Optimal electrical conditions in electrical impulse chemotherapy. Jpn J Cancer Res 1992; 83: 1095-101.
8. Belehradek M, Domenge C, Luboinski B, et al. Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer 1993; 72: 3694-700.
9. Domenge C, Orlowski S, Luboinski B, et al. Antitumor electrochemotherapy. New advances in the clinical protocol. Cancer 1996; 77: 956-63.
10. Heller R, Jaroszeski M, Glass F, et al. I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy. Cancer 1996; 77: 964-71.
11. Rudolf Z, Štabuc B, Čemažar M, et al. Electrochemotherapy with bleomycin: the first clinical experience in malignant melanoma patients. Radiol Oncol 1995; 29: 229-35.
12. Čemažar M, Miklavčič D, Vodovnik L, et al. Improved therapeutic effect of electrochemotherapy with cisplatin by intratumoral druf administration and changing of electrode orientation for electropermeabilization on EAT tumor model in mice. Radiol Oncol 1995; 29: 121-7.
13. Dev SB, Hofmann GA. Electrochemotherapy - a novel method of cancer treatment. Cancer Treat Rev 1994; 20: 105-15.
14. Melvik JE, Pettersen EO, Gordon PB, et al. Increase in cisdichlorodiammineplatinum(II) cytotoxicity upon reversible electropermeabilization of the plasma membrane in cultured human NHIK 3025 cells. Eur J Cancer Clin Oncol 1986; 22: 1523-30.
15. Serša G, Čemažar M, Miklavčič D. Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice. Cancer Res 1995; 55: 3450-5.
16. Begg AC, Bartelink H, Stewart FA, et al. Improvement of differential toxicity between tumor and normal tissues using intratumoral injection with or without a slow-drug-release matrix system. NCI Monogr 1988; 6: 133-6.
17. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
18. Milačič R, Čemažar M, Serša G. Determination of platinum in tumor tissues after cisplatin therapy by electrothermal atomic absorption spectroscopy. J Pharm Biomed Anal 1997; 16: 343-8.
19. Begg AC, Deurloo MJ, Kop W, et al. Improvement of combined modality treatment with cisplatin and radiation using intratumoral drug administration in murine tumors. Radiother Oncol 1991; 31: 129-33.
20. Landrito JE, Yoshiga K, Sakurai K, et al. Effects of intralesional injection of cisplatin on squamous cell carcinoma and normal tissue of mice. Anticancer Res 1994; 14: 113-8.
21. De Vita V T Jr, Hellman S, Rosenberg SA, eds. Biologic therepy of cancer. Philadelphia: Lippincott 1991.
22. Deurloo MJ, Bohlken S, Kop W, et al. Intratumoral administration of cisplatin in slow-release devices. I. Tumor response and toxicity. Cancer Chemother Pharmacol 1990; 27: 135-40.
23. Deurloo MJ, Kop W, van Tellingen O, et al. Intratumoral administration of cisplatin in slow-release devices. II. Pharmacokinetics and intratumoral distribution. Cancer Chemother Pharmacol 1991; 27: 347-53.
24. Kuang L, Yang DJ, Inoue T, et al. Percutaneous intratumoral injection of cisplatin microspheres in tumor-bearing rats to diminish acute nephrotoxicity. Anti-Cancer Drugs 1996; 7: 220-7.
25. Smith JP, Stock E, Orenberg EK, et al. Intratumoral chemotherapy with a sustained-release drug delivery system inhibits growth of a human pancreatic cancer xenografts. Anti-Cancer Drugs 1995; 6: 717-26.
26. Steerenberg PA, Storm G, de Groot G, et al. Liposomes as a drug Carrier system for cis-diamminedichloroplatinum(II). II. Antitumor activity in vivo, induction of drug resistance, nephrotoxicity and Pt distribution. Cancer Chemother Pharmacol 1988; 21: 299-307.
27. Vadiei K, Siddik ZH, Khokhar AR, et al. Pharmacokinetics of liposome-entrapped cis-bis-neodecanoato-R,R-1,2-diamminecyclohexaneplatinum(II) and cisplatin given i.v. and i.p. in the rat. Cancer Chemother Pharmacol 1992; 30: 365-9.
28. Jekunen AP, Shalinsky DR, Hom DK, et al. Modulation of cisplatin cytotoxicity by permeabilization of the plasma membrane by digitonin in in vitro. Biochem Pharmacol 1993; 45: 2079-85.
29. Serša G, Štabuc B, Čemažar M, et al. Electrochemotherapy with cisplatin: potentiation of local cisplatin antitumor effectiveness by application of electric pulses in cancer patients. Eur J Cancer 1998; in press.