메뉴 건너뛰기




Volumn 14, Issue 23, 2004, Pages 5809-5812

Synthesis of small molecule CDC25 phosphatases inhibitors

Author keywords

Antiproliferative agent; CDC25 inhibitor; Dual specificity phosphatases inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; BN 82002; LEAD; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; SMALL MOLECULE TRANSPORT AGENT; UNCLASSIFIED DRUG;

EID: 7044229678     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.041     Document Type: Article
Times cited : (26)

References (21)
  • 13
    • 7044244490 scopus 로고    scopus 로고
    • note
    • 3)
  • 15
    • 7044258561 scopus 로고    scopus 로고
    • note
    • Borohydride, polymer supported (on Amberlite® IRA-400), supplier: Aldrich Chemical Company, Inc
  • 16
    • 7044255759 scopus 로고    scopus 로고
    • note
    • 4-Benzyloxybenzaldehyde polystyrene HL (200-400 mesh), 2% DVB, supplier Novabiochem
  • 17
    • 7044278662 scopus 로고    scopus 로고
    • note
    • Methylisothiocyanate polystyrene HL (200-400 mesh), 2% DVB, supplier Novabiochem
  • 18
    • 7044282226 scopus 로고    scopus 로고
    • note
    • Compounds 7a-n: 50 μmol of aldehyde 5 was added to a mixture of amine 6 (60 μmol, 1.2 equiv) and triethylamine (66 μmol, 1.3 equiv), in anhydrous methanol (1 mL) and the resulting mixture was stirred at room temperature for 18 h. Borohydride (100 μmol, 2 equiv) supported on resin were then added and stirring was maintained for 2 additional hours. Compounds 7a-l: 60 μmol (1.2 equiv) of 4-benzyloxybenzaldehyde polystyrene resin was added and the mixture stirred for 18 h at room temperature. Compounds 7m and 7n: 60 μmol (1.2 equiv) of methylisothiocyanate polystyrene resin was added and the mixture stirred for 18 h at room temperature. In both cases, the resins were filtered and washed with MeOH. The solvent was evaporated and compounds 7a-n were obtained as yellow oils
  • 19
    • 7044279330 scopus 로고    scopus 로고
    • note
    • Mass spectra were acquired on a single quadrupole electrospray mass spectrometer (Micromass, Platform model) and HPLC retention times were acquired on an HPLC system (HP 1100) equipped with a photodiode array UV detector


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.