Tumor cell growth inhibition and extracellular signal-regulated kinase (ERK) phosphorylation by novel K vitamins

Journal of Molecular Biology

Volumn 314, Issue 4, 2001, Pages 765-772

  Osada, Shinji ^a,b   Osada, Kazuko ^a,b   Carr, Brian I ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cancer cell line; Extracellular signal regulated kinase (ERK); Growth inhibition; Novel K vitamin analog; Phosphorylation

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 (2 HYDROXY ETHYLSULFANYL) 3 METHYL 1,4 NAPHTHOQUINONE; 2 (2 HYDROXY ETHYLSULFANYL) 3 METHYL 5 ACETYLAMINO 1,4 NAPHTHOQUINONE; 2 (2 HYDROXY ETHYLSULFANYL) 3 METHYL 5 NITRO 1,4 NAPHTHOQUINONE; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VITAMIN K GROUP;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; DRUG EFFECT; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; TUMOR;

EID: 0035824867     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5171     Document Type: Article

References (27)

1. Anthracyclline antibiotics in cancer therapy: Focus on drug resistance
2. Modulation of cisplatin sensitivity and accumulation by amphotercin-B in cisplatin-resistant human lung-cancer cell lines
3. Growth inhibition of hepatoma cells by vitamin K and its analogs
4. Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep 3B and Hep G2
5. Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation
6. Protein-tyrosine phosphatases
7. Screening for antimitotic compounds using the cdc 25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase
8. Inhibition of hepatoma cell growth in vitro by arylating and non-arylating K vitamin analogs
9. Mitogen activated protein kinases p42 and p44 are required for fibroblast proliferation
10. Critical role of extracellular signal-regulated kinase (ERK) phosphorylation in novel vitamin K analog-induced cell death
11. Identification of a novel inhibitor of mitogenactivated protein kinase
12. Requirement for ceramide-initiated SAPK/JNK signalling in stressinduced apoptosis
13. Treatment of pancreatic cancer: Current limitations, future possibilities
14. Prediction of response to 5′-deoxy-5-fluorouridine (5′-DFUR) in patients with inoperable advanced gastric cancer by immunostaining of thymidine phosphorylase platelet-derived endothelial cell growth factor
15. Growth inhibition: Nuclear uptake and retention of anthracycline formaldehyde conjugates in prostatae cancer cells relative to clinical anthracyclins
16. Protein tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils
17. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
18. Tumorigenicity of the Met protooncogene and the gene for hepatocyte growth factor
19. Hepatocyte growth factor scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers
20. Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells
21. Signal transduction by receptors with tyrosine kinase activity
22. Cellular growth response to epidermal growth factor in colon carcinoma cells with adenomatous polyposis patient
23. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
24. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
25. Role of mitogen-activated protein kinases in activation-induced apoptosis of T cells
26. Critical role of extracellular signal-regulated kinase phosphorylation on menadione (vitamin K3) induced growth inhibition
27. Mechanism of novel vitamin K analog induced growth inhibition in human hepatoma cell line