Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line

Toxicology in Vitro

Volumn 16, Issue 1, 2002, Pages 23-31

  Leira, F ^a   Alvarez, C ^a   Vieites, J M ^a   Vieytes, M R ^b   Botana, L M ^b  

^a ANFACO CECOPESCA   (Spain)

^b Facultad de Veterinaria   (Spain)

Author keywords

Apoptosis; Microplate assay; Neuroblastoma; Okadaic acid; Yessotoxin

Indexed keywords

CASPASE 3; ENZYME INHIBITOR; LIPOCORTIN 5; MARINE TOXIN; NUCLEIC ACID; OKADAIC ACID; UNCLASSIFIED DRUG; YESSOTOXIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVATION; FLUOROMETRY; IC 50; MEMBRANE POTENTIAL; METHODOLOGY; MITOCHONDRIAL MEMBRANE; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN BINDING;

ANNEXIN A5; APOPTOSIS; CASPASE 3; CASPASES; CELL ADHESION; DNA FRAGMENTATION; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHERS, CYCLIC; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; MOLLUSK VENOMS; NEUROBLASTOMA; OKADAIC ACID; OXOCINS; RNA, NEOPLASM; TUMOR CELLS, CULTURED;

EID: 0036151289     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(01)00095-9     Document Type: Article

References (37)

1. Utilization of a fos-lacZ plasmid to investigate the activation of c-fos during cellular senescence and okadaic acid-induced apoptosis
2. Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity
3. Apoptosis of human myeloid leukemia cells induced by an inhibitor of protein phosphatases (okadaic acid) is prevented by Bcl-2 and Bcl-X (L)
4. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases (Specificity and kinetics)
5. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
6. Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation
7. Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9
8. Assays of cell viability: Discrimination of cells dying by apoptosis
9. Differential selectivity of normal and H-ras oncogene transformed rat kidney epithelial cells to okadaic acid-induced apoptosis
10. Characterization of a renal epithelial cell model of apoptosis using okadaic acid and the NRK-52E cell line
11. Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure
12. Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors
13. Correlated flow cytometric analysis of terminal events in apoptosis reveals the absence of some changes in some model systems
14. Mitochondria and apoptosis
15. Treatment of myeloid leukemic cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose
16. Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A
17. Apoptosis in favourable neuroblastomas is not dependent on Fas (CD95/APO-1) expression but on activated caspase-3 (CPP32)
18. Cell damage by near-IR microbeams
19. Comparative analysis of different methodological approaches to the in vitro study of drug-induced apoptosis
20. Apoptotic events induced by the phosphatase inhibitor okadaic acid in normal human lung fibroblasts
21. Down-regulation of c-Myc and Max genes is associated to inhibition of protein phosphatase 2A in K562 human leukemia cells
22. The permeability transition pore complex: A target for apoptosis regulation by caspases and bcl-2 related proteins
23. Caspases disrupt mitochondrial membrane barrier function
24. The protein phosphatase inhibitor okadaic acid and calyculin A induces apoptosis in human osteoblastic cells
25. Okadaic acid-induced apoptosis in neuronal cells: Evidence for an abortive mitotic attempt
26. Detection of apoptosis in live cells by MitoTracker red CMXRos and SYTO dye flow cytometry
27. Okadaic acid-induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl-2 mRNA and downregulation of bcl-2 protein
28. Altered lipid packing identifies apoptotic thymocytes
29. Inhibition of apoptosis in human tumour cells by okadaic acid
30. Histopathological studies on experimental marine toxin poisoning. The effects in mice of yessotoxin isolated from Patinopecten yessoensis and of a desulfated derivative
31. Inhibitors of ser/thr phosphatases 1 and 2A induce apoptosis in pituitary GH3 cells
32. A novel assay for apoptosis (Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.)
33. Apoptosis induction by inhibitors of Ser/Thr phosphatases 1 and 2A is associated with transglutaminase activation in two different human epithelial tumour lines
34. Cell death: The significance of apoptosis
35. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation
36. New toxins and their toxicological evaluations
37. Caspase activation without death