Okadaic acid stimulates caspase-like activities and induces apoptosis of cultured rat mesangial cells

Molecular and Cellular Biochemistry

Volumn 260, Issue 1, 2004, Pages 7-11

  Parameswaran, Narayanan ^a   Spielman, Wiliam S ^a   Brooks, David P ^b   Nambi, Ponnal ^b,c  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c PFIZER INC   (United States)

Author keywords

Apoptosis; Caspase 3; caspase 8; Mesangial cells; Okadaic acid; Protein phosphatase 2A

Indexed keywords

BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 8; CASPASE 8 INHIBITOR; CYCLOHEXIMIDE; DNA FRAGMENT; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; PROTEIN SYNTHESIS INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; GLOMERULOSCLEROSIS; HYDROLYSIS; INHIBITION KINETICS; MESANGIUM CELL; MOLECULAR MECHANICS; NONHUMAN; NUCLEOSOME; PATHOPHYSIOLOGY; PROTEIN SYNTHESIS; RAT; TIME;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASES; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLOMERULAR MESANGIUM; HYDROLYSIS; OKADAIC ACID; OLIGOPEPTIDES; RATS;

EID: 4344595996     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MCBI.0000026041.41078.32     Document Type: Article

References (21)

1. Klahr S, Schreiner G, Ichikawa I: The progression of renal disease. N Engl J Med 318: 1657-1666, 1988
2. el Nahas AM, Muchaneta-Kubara EC, Essawy M, Soylemezoglu O: Renal fibrosis: Insights into pathogenesis and treatment. Int J Biochem Cell Biol 29: 55-62, 1997
3. Baker AJ, Mooney A, Hughes J, Lombardi D, Johnson RJ, Savill J: Mesangial cell apoptosis: The major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J Clin Invest 94: 2105-2116, 1994
4. Sugiyama H, Kashihara N, Makino H, Yamasaki Y, Ota A: Apoptosis in glomerular sclerosis. Kidney Int 49: 103-111, 1996
5. Cohen GM: Caspases: The executioners of apoptosis. Biochem J 326: 1-16, 1997
6. Villa P, Kaufmann SH, Earnshaw WC: Caspases and caspase inhibitors. Trends Biochem Sci 22: 388-393, 1997
7. Nagao M, Shima H, Nakayasu M, Sugimura T: Protein serine/threonine phosphatases as binding proteins for okadaic acid. Mutat Res 333: 173-179, 1995
8. Cohen P, Holmes CF, Tsukitani Y: Okadaic acid: A new probe for the study of cellular regulation. Trends Biochem Sci 15: 98-102, 1990
9. Fujiki H, Suganuma M: Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds. Adv Cancer Res 61: 143-194, 1993
10. Song Q, Baxter GD, Kovacs EM, Findik D, Lavin MF: Inhibition of apoptosis in human tumour cells by okadaic acid. J Cell Physiol 153: 550-556, 1992
11. Morimoto Y, Ohba T, Kobayashi S, Haneji T: The protein phosphatase inhibitors okadaic acid and calyculin A induce apoptosis in human osteoblastic cells. Exp Cell Res 230: 181-186, 1997
12. Li DW, Fass U, Huizar I, Spector A: Okadaic acid-induced lens epithelial cell apoptosis requires inhibition of phosphatase-1 and is associated with induction of gene expression including p53 and bax. Eur J Biochem 257: 351-361, 1998
13. Albrightson CR, Nambi P, Zabko-Potapovich B, Dytko G, Groom T: Effect of thrombin on proliferation, contraction and prostaglandin production of rat glomerular mesangial cells in culture. J Pharmacol Exp Ther 263: 404-412, 1992
14. Yue TL, Wang C, Romanic AM, Kikly K, Keller P, DeWolf WE Jr., Hart TK, Thomas HC, Storer B, Gu JL, Wang X, Feuerstein GZ: Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3. J Mol Cell Cardiol 30: 495-507, 1998
15. Dimmeler S, Rippmann V, Weiland U, Haendeler J, Zeiher AM: Angiotensin II induces apoptosis of human endothelial cells. Protective effect of nitric oxide. Circ Res 81: 970-976, 1997
16. Ohta T, Kinoshita T, Naito M, Nozaki T, Masutani M, Tsuruo T, Miyajima A: Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells. J Biol Chem 272: 23111-23116, 1997
17. Kagaya S, Kitanaka C, Noguchi K, Mochizuki T, Sugiyama A, Asai A, Yasuhara N, Eguchi Y, Tsujimoto Y, Kuchino Y: A functional role for death proteases in s-myc- and c-myc-mediated apoptosis. Mol Cell Biol 17: 6736-6745, 1997
18. Kaushal GP, Singh AB, Shah SV: Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury. Am J Physiol 274: F587-F595, 1998
19. DiMari J, Megyesi J, Udvarhelyi N, Price P, Davis R, Safirstein R: N-acetyl cysteine ameliorates ischemic renal failure. Am J Physiol 272: F292-F298, 1997
20. Juo P, Kuo CJ, Reynolds SE, Konz RE, Raingeaud J, Davis RJ, Biemann HP, Blenis J: Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Mol Cell Biol 17: 24-35, 1997
21. Parameswaran N, Nambi P, Hall CS, Brooks DP, Spielman WS: Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells. Eur J Pharmacol 388: 133-138, 2000