A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice

Journal of Experimental and Clinical Cancer Research

Volumn 23, Issue 4, 2004, Pages 599-606

  Horiuchi, H ^a,b   Kawamata, Hitoshi ^a   Furihata, T ^a   Omotehara, F ^a   Hori, H ^a,b   Shinagawa, Y ^a   Ohkura, Y ^a   Tachibana, M ^a   Yamazaki, T ^a   Ajiki, T ^b   Kuroda, Y ^b   Fujimori, T ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Gallbladder cancer; MEK inhibitor; Metastasis; MMP; Orthotopic inoculation; TIMP; UPA

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; GELATINASE A; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; PROTEIN KINASE INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GRAFT; CANCER INVASION; CANCER SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; GALLBLADDER CANCER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIVER METASTASIS; LUNG METASTASIS; LYMPH NODE METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; BUTADIENES; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME INHIBITORS; FLAVONOIDS; GALLBLADDER NEOPLASMS; HUMANS; LIVER; LIVER NEOPLASMS; LYMPHATIC METASTASIS; MAP KINASE KINASE 1; MICE; MICE, NUDE; MODELS, ANATOMIC; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NITRILES; URINARY PLASMINOGEN ACTIVATOR;

EID: 19944432716     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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