Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3687-3693

  Valderrama, Jaime A ^a   Leiva, Hilda ^a   Rodríguez, Jaime A ^b   Theoduloz, Cristina ^b   Schmeda Hirshmann, Guillermo ^b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSIDAD DE TALCA   (Chile)

Author keywords

1,4 Naphthoquinones; Coronands; Cytotoxicity; Nucleophilic substitution; Podands

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 CHLORO 3 (2 METHOXYETHYOXY)NAPHTHALENE 1,4 DIONE; 2 METHOXY 3 CHLORO 1,4 NAPHTHOQUINONE; 2,3 DIHYDRONAPHTHO[2,3 B]1,4 DIOXIN 5,10 DIONE; 2,3 DIMETHOXY 1,4 NAPHTHOQUINONE; 2,3,5,6 TETRAHYDRONAPHTHO[2,3 B]1,4,7 TRIOXONIN 8,13 DIONE; 2,3,5,6,8,9 HEXAHYDRONAPHTHO[2,3 B]1,4,7,10 TETRAOXACYCLODODECIN 11,16 DIONE; 3,3' [2,2' [2',2' OXYBIS(ETHANE 2,1 DIYL)BIS(OXY)]BIS(ETHANE 2,1 DIYL)]BIS(OXY)BIS(2 CHLORONAPHTHALENE 1,4 DIONE); 3,3' [2,2' [ETHANE 1,2 DIYLBIS(OXY)]BIS(ETHANE 2,1 DIYL)]BIS(OXY)BIS(2 CHLORONAPHTHALENE 1,4 DIONE); 3,3' [2,2' OXY(BIS)] [ETHANE 2,1 DIYLBIS(OXY)]BIS(2 CHLORONAPHTHALENE 1,4 DIONE); ETOPOSIDE; POLYOXYETHYLENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; ENERGY; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; MOLECULAR SIZE;

CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; MOLECULAR STRUCTURE; NAPHTHOQUINONES; POLYETHYLENE GLYCOLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41849139696     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.018     Document Type: Article

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