2- or 6-(1-azidoalkyl)-5,8-dimethoxy-1,4-naphthoquinone: Synthesis, evaluation of cytotoxic activity, antitumor activity and inhibitory effect on DNA topoisomerase-I

Archives of Pharmacal Research

Volumn 22, Issue 5, 1999, Pages 507-514

  Chae, Gyu Han ^a   Song, Gyu Yong ^a   Kim, Yong ^a   Cho, Hoon ^b   Sok, Dai Eun ^a   Ahn, Byung Zun ^a  

^a Chungnam National University   (South Korea)

^b Kuhnil Pharmaceutical Co LTD   (South Korea)

Author keywords

Antitumor activity; Azidoalkylated naphthoquinones; DNA topoisomerase I inhibition; Structure activity relationship

Indexed keywords

ANTINEOPLASTIC AGENT; AZIDE; DNA TOPOISOMERASE; ENZYME INHIBITOR; NAPHTHOQUINONE;

ANIMAL; ARTICLE; CANCER TRANSPLANTATION; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; INSTITUTE FOR CANCER RESEARCH MOUSE; LEUKEMIA L 1210; MALE; MOUSE; PATHOLOGY; SARCOMA; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; AZIDES; CHROMATOGRAPHY, THIN LAYER; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; LEUKEMIA L1210; MALE; MICE; MICE, INBRED ICR; NAPHTHOQUINONES; NEOPLASM TRANSPLANTATION; SARCOMA, EXPERIMENTAL; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0033203651     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02979161     Document Type: Article

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