Studies on quinones. Part 39: Synthesis and leishmanicidal activity of acylchloroquinones and hydroquinones

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 13, 2005, Pages 4153-4159

  Valderrama, Jaime A ^a   Zamorano, Carlos ^a   González, M Florencia ^a   Prina, Eric ^b   Fournet, Alain ^c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b INSTITUT PASTEUR   (France)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

Author keywords

Diels Alder reaction; Enolization; Leishmanicidal activity; Lipophilicity; Quinones

Indexed keywords

2 ACETYL 3 CHLORO 1,4 BENZOQUINONE; 2,5 DIHYDROXY 6 CHLOROACETOPHENONE; 2,5 DIHYDROXY 6 CHLOROBENZALDEHYDE; 6 ACETYL 7 CHLORO 1,4 DIHYDRO 1,4 ETHANONAPHTHALENE 5,8 DIONE; 6 ACETYL 7 CHLORO 1,4 DIHYDRO 1,4 METHANONAPHTHALENE 5,8 DIONE; 6 ACETYL 7 CHLORO 5,8 DIHYDROXY 1,4 DIHYDRO 1,4 ETHANONAPHTHALENE; 6 ACETYL 7 CHLORO 5,8 DIHYDROXY 1,4 DIHYDRO 1,4 METHANONAPHTHALENE; ALKENE DERIVATIVE; CHLOROQUINONE; HYDROQUINONE DERIVATIVE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; LEISHMANIA; LIPOPHILICITY; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPROTOZOAL AGENTS; FEMALE; HYDROQUINONES; INHIBITORY CONCENTRATION 50; LEISHMANIA MEXICANA; MACROPHAGES; MICE; MICE, INBRED BALB C; QUINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

BETULACEAE; LEISHMANIA AMAZONENSIS;

EID: 20344400615     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.041     Document Type: Article

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