Mutational analysis of the α1a-adrenergic receptor binding pocket of antagonists by radioligand binding assay

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 4, 2008, Pages 598-601

  Ahmed, Maruf ^a   Hossain, Murad ^b   Bhuiyan, Mohiuddin Ahmed ^b   Ishiguro, Masaji ^b   Tanaka, Takashi ^c   Muramatsu, Ikunobu ^c   Nagatomo, Takafumi ^b  

^a UNIVERSITY OF RAJSHAHI   (Bangladesh)

^b NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^c UNIVERSITY OF FUKUI   (Japan)

Author keywords

1a adrenergic receptor; Binding assay; Binding pocket; Site directed mutagenesis

Indexed keywords

ALANINE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ASPARTIC ACID; GLUTAMINE; PHENYLALANINE; PRAZOSIN; RADIOLIGAND; RHODOPSIN; SILODOSIN; TAMSULOSIN; TRITIUM;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL STRAIN HEK293; COMPUTER SIMULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CULTURE MEDIUM; HUMAN; HUMAN CELL; LIGAND BINDING; PROTEIN DOMAIN; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS;

ADRENERGIC ALPHA-ANTAGONISTS; CELL LINE; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; HUMANS; INDOLES; MUTAGENESIS, SITE-DIRECTED; PRAZOSIN; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-1; SULFONAMIDES; TRANSFECTION;

EID: 41849105443     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.598     Document Type: Article

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