Identification of binding sites of prazosin, tamsulosin and KMD-3213 with α1-adrenergic receptor subtypes by molecular modeling

Life Sciences

Volumn 71, Issue 21, 2002, Pages 2531-2541

  Ishiguro, Masaji ^a   Futabayashi, Yukiyo ^b   Ohnuki, Toshio ^b   Ahmed, Maruf ^b   Muramatsu, Ikunobu ^c   Nagatomo, Takafumi ^b  

^a SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^b NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^c UNIVERSITY OF FUKUI   (Japan)

Author keywords

1 antagonists; Human cloned CHO cells; Molecular modeling; Radioligand binding

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ETHYL 3,4,5 TRIMETHOXY ALPHA [3 [[2 (2 METHOXYPHENOXY)ETHYL]AMINO]PROPYL]BENZENEACETONITRILE FUMARATE; AMOSULALOL; CLONIDINE; KETANSERIN; PRAZOSIN; RECEPTOR SUBTYPE; SILODOSIN; TAMSULOSIN; TERAZOSIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN;

ADRENERGIC ALPHA-ANTAGONISTS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; HUMANS; INDOLES; MESOCRICETUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PRAZOSIN; RECEPTORS, ADRENERGIC, ALPHA-1; SULFONAMIDES; TRANSFECTION;

EID: 0037063701     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)02077-5     Document Type: Article

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