메뉴 건너뛰기




Volumn 176, Issue 3, 2008, Pages 310-319

The efficacy and tolerability of levetiracetam in pharmacoresistant epileptic dogs

Author keywords

Antiepileptic drug; Dog; Levetiracetam; Refractory; Seizure

Indexed keywords

BROMIDE; ETIRACETAM; GABAPENTIN; PHENOBARBITAL; TOPIRAMATE;

EID: 41749104485     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2007.03.002     Document Type: Article
Times cited : (101)

References (67)
  • 2
    • 4544246619 scopus 로고    scopus 로고
    • Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines
    • Beghi E. Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines. Lancet Neurology 3 (2004) 618-621
    • (2004) Lancet Neurology , vol.3 , pp. 618-621
    • Beghi, E.1
  • 4
    • 1842779114 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and metabolism of levetiracetam, a new anti-epileptic agent, in mouse, rat, rabbit and dog
    • Benedetti M.S., Coupez R., Whomsley R., Nicolas J.M., Collart P., and Baltes E. Comparative pharmacokinetics and metabolism of levetiracetam, a new anti-epileptic agent, in mouse, rat, rabbit and dog. Xenobiotica 34 (2004) 281-300
    • (2004) Xenobiotica , vol.34 , pp. 281-300
    • Benedetti, M.S.1    Coupez, R.2    Whomsley, R.3    Nicolas, J.M.4    Collart, P.5    Baltes, E.6
  • 5
    • 42949150573 scopus 로고    scopus 로고
    • Berendt, M., 2004. Epilepsy. In: Vite, C.H. (Ed.), Braund's Clinical Neurology in Small Animals: Localization, Diagnosis and Treatment, International Veterinary Information Service, Ithaca, NY, USA (www.ivis.org), July 2004. http://www.ivis.org/advances/Vite/berendt/chapter_frm.asp?LA=1 (accessed 10 October 2006).
    • Berendt, M., 2004. Epilepsy. In: Vite, C.H. (Ed.), Braund's Clinical Neurology in Small Animals: Localization, Diagnosis and Treatment, International Veterinary Information Service, Ithaca, NY, USA (www.ivis.org), July 2004. http://www.ivis.org/advances/Vite/berendt/chapter_frm.asp?LA=1 (accessed 10 October 2006).
  • 6
    • 0032617470 scopus 로고    scopus 로고
    • Epilepsy and seizure classification in 63 dogs: a reappraisal of veterinary epilepsy terminology
    • Berendt M., and Gram L. Epilepsy and seizure classification in 63 dogs: a reappraisal of veterinary epilepsy terminology. Journal of Veterinary Internal Medicine 13 (1999) 14-20
    • (1999) Journal of Veterinary Internal Medicine , vol.13 , pp. 14-20
    • Berendt, M.1    Gram, L.2
  • 7
    • 0000219847 scopus 로고    scopus 로고
    • Analysis of the "honeymoon effect" in adult epilepsy patients
    • Boggs J.G., Nowack W.J., and Drinkard C.R. Analysis of the "honeymoon effect" in adult epilepsy patients. Epilepsia 41 (2000) 222
    • (2000) Epilepsia , vol.41 , pp. 222
    • Boggs, J.G.1    Nowack, W.J.2    Drinkard, C.R.3
  • 8
    • 4544254014 scopus 로고    scopus 로고
    • Levetiracetam safety profiles and tolerability in epilepsy patients
    • Briggs D.E., and French J.A. Levetiracetam safety profiles and tolerability in epilepsy patients. Expert Opinion on Drug Safety 3 (2004) 415-424
    • (2004) Expert Opinion on Drug Safety , vol.3 , pp. 415-424
    • Briggs, D.E.1    French, J.A.2
  • 9
    • 33846850154 scopus 로고    scopus 로고
    • Brodie, M.G., Perucca, E., Ryvlin, P., Ben-Menachem, E., Meencke, H.J., 2007. Levetiracetam Monotherapy Study Group. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 68, 402-408.
    • Brodie, M.G., Perucca, E., Ryvlin, P., Ben-Menachem, E., Meencke, H.J., 2007. Levetiracetam Monotherapy Study Group. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 68, 402-408.
  • 10
    • 33746731746 scopus 로고    scopus 로고
    • Canine epilepsy: what can we learn from human seizure disorders?
    • Chandler K. Canine epilepsy: what can we learn from human seizure disorders?. The Veterinary Journal 172 (2006) 207-217
    • (2006) The Veterinary Journal , vol.172 , pp. 207-217
    • Chandler, K.1
  • 16
    • 0032942934 scopus 로고    scopus 로고
    • Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat
    • Doheny H.C., Ratnaraj N., Whittington M.A., Jefferys J.G., and Patsalos P.N. Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat. Epilepsy Research 34 (1999) 161-168
    • (1999) Epilepsy Research , vol.34 , pp. 161-168
    • Doheny, H.C.1    Ratnaraj, N.2    Whittington, M.A.3    Jefferys, J.G.4    Patsalos, P.N.5
  • 17
    • 23944500894 scopus 로고    scopus 로고
    • Fast and sustained efficacy of levetiracetam during titration and the first 3 months of treatment in refractory epilepsy
    • French J., di Nicola S., and Arrigo C. Fast and sustained efficacy of levetiracetam during titration and the first 3 months of treatment in refractory epilepsy. Epilepsia 46 (2005) 1304-1307
    • (2005) Epilepsia , vol.46 , pp. 1304-1307
    • French, J.1    di Nicola, S.2    Arrigo, C.3
  • 21
    • 33645813802 scopus 로고    scopus 로고
    • Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein
    • Gillard M., Chatelain P., and Fuks B. Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein. European Journal of Pharmacology 536 (2006) 102-108
    • (2006) European Journal of Pharmacology , vol.536 , pp. 102-108
    • Gillard, M.1    Chatelain, P.2    Fuks, B.3
  • 23
    • 0036221629 scopus 로고    scopus 로고
    • Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy
    • Glien M., Brandt C., Potschka H., and Löscher W. Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy. Epilepsia 43 (2002) 350-357
    • (2002) Epilepsia , vol.43 , pp. 350-357
    • Glien, M.1    Brandt, C.2    Potschka, H.3    Löscher, W.4
  • 24
    • 33644828150 scopus 로고    scopus 로고
    • Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent
    • Govendir M., Perkins M., and Malik R. Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. Australian Veterinary Journal 83 (2005) 602-608
    • (2005) Australian Veterinary Journal , vol.83 , pp. 602-608
    • Govendir, M.1    Perkins, M.2    Malik, R.3
  • 25
    • 0028823233 scopus 로고
    • Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy
    • Gower A.J., Hirsch E., Boehrer A., Noyer M., and Marescaux C. Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy. Epilepsy Research 22 (1995) 207-213
    • (1995) Epilepsy Research , vol.22 , pp. 207-213
    • Gower, A.J.1    Hirsch, E.2    Boehrer, A.3    Noyer, M.4    Marescaux, C.5
  • 27
    • 0034878396 scopus 로고    scopus 로고
    • Safety profile of levetiracetam
    • Harden C. Safety profile of levetiracetam. Epilepsia 42 (2001) 36-39
    • (2001) Epilepsia , vol.42 , pp. 36-39
    • Harden, C.1
  • 28
    • 42949106914 scopus 로고    scopus 로고
    • Holt, G., Volk, H.A., Chandler, K., 2005. The use of a questionnaire to compare clinical characteristics and type of seizure occurring in 3 dog breeds with idiopathic epilepsy. In: Proceedings of 18th Annual European College of Veterinary Neurologist Symposium, Munich, Germany.
    • Holt, G., Volk, H.A., Chandler, K., 2005. The use of a questionnaire to compare clinical characteristics and type of seizure occurring in 3 dog breeds with idiopathic epilepsy. In: Proceedings of 18th Annual European College of Veterinary Neurologist Symposium, Munich, Germany.
  • 29
    • 0035169113 scopus 로고    scopus 로고
    • Levetiracetam: a novel antiepileptic drug
    • Hovinga C.A. Levetiracetam: a novel antiepileptic drug. Pharmacotherapy 21 (2001) 1375-1388
    • (2001) Pharmacotherapy , vol.21 , pp. 1375-1388
    • Hovinga, C.A.1
  • 30
    • 0034849129 scopus 로고    scopus 로고
    • Pharmacokinetics of levetiracetam and its enantiomer (R)-alpha-ethyl-2-oxo-pyrrolidine acetamide in dogs
    • Isoherranen N., Yagen B., Soback S., Roeder M., Schurig V., and Bialer M. Pharmacokinetics of levetiracetam and its enantiomer (R)-alpha-ethyl-2-oxo-pyrrolidine acetamide in dogs. Epilepsia 42 (2001) 825-830
    • (2001) Epilepsia , vol.42 , pp. 825-830
    • Isoherranen, N.1    Yagen, B.2    Soback, S.3    Roeder, M.4    Schurig, V.5    Bialer, M.6
  • 32
    • 0034864144 scopus 로고    scopus 로고
    • Levetiracetam: the preclinical profile of a new class of antiepileptic drugs?
    • Klitgaard H. Levetiracetam: the preclinical profile of a new class of antiepileptic drugs?. Epilepsia 42 (2001) 13-18
    • (2001) Epilepsia , vol.42 , pp. 13-18
    • Klitgaard, H.1
  • 33
    • 0032563178 scopus 로고    scopus 로고
    • Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy
    • Klitgaard H., Matagne A., Gobert J., and Wulfert E. Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. European Journal of Pharmacology 353 (1998) 191-206
    • (1998) European Journal of Pharmacology , vol.353 , pp. 191-206
    • Klitgaard, H.1    Matagne, A.2    Gobert, J.3    Wulfert, E.4
  • 34
    • 17744406684 scopus 로고    scopus 로고
    • Antiepileptogenesis, neuroprotection, and disease modification in the treatment of epilepsy: focus on levetiracetam
    • Klitgaard H., and Pitkanen A. Antiepileptogenesis, neuroprotection, and disease modification in the treatment of epilepsy: focus on levetiracetam. Epileptic Disorders 5 Supp. 1 (2003) S9-S16
    • (2003) Epileptic Disorders , vol.5 , Issue.SUPPL. 1
    • Klitgaard, H.1    Pitkanen, A.2
  • 35
    • 0035954353 scopus 로고    scopus 로고
    • Long-term continuation of levetiracetam in patients with refractory epilepsy
    • Krakow K., Walker M., Otoul C., and Sander J.W.A.S. Long-term continuation of levetiracetam in patients with refractory epilepsy. Neurology 56 (2001) 1772-1774
    • (2001) Neurology , vol.56 , pp. 1772-1774
    • Krakow, K.1    Walker, M.2    Otoul, C.3    Sander, J.W.A.S.4
  • 37
    • 0041877663 scopus 로고    scopus 로고
    • Pharmakologische Grundlagen zur Behandlung der Epilepsie bei Hund und Katze
    • Löscher W. Pharmakologische Grundlagen zur Behandlung der Epilepsie bei Hund und Katze. Der Praktische Tierarzt 8 (2003) 574-586
    • (2003) Der Praktische Tierarzt , vol.8 , pp. 574-586
    • Löscher, W.1
  • 38
    • 0027410987 scopus 로고
    • Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats
    • Löscher W., and Honack D. Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats. European Journal of Pharmacology 232 (1993) 147-158
    • (1993) European Journal of Pharmacology , vol.232 , pp. 147-158
    • Löscher, W.1    Honack, D.2
  • 39
    • 0031908063 scopus 로고    scopus 로고
    • Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy
    • Löscher W., Honack D., and Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. Journal of Pharmacology and Experimental Therapeutics 284 (1998) 474-479
    • (1998) Journal of Pharmacology and Experimental Therapeutics , vol.284 , pp. 474-479
    • Löscher, W.1    Honack, D.2    Rundfeldt, C.3
  • 40
    • 33746887419 scopus 로고    scopus 로고
    • Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs
    • Löscher W., and Schmidt D. Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs. Epilepsia 47 (2006) 1253-1284
    • (2006) Epilepsia , vol.47 , pp. 1253-1284
    • Löscher, W.1    Schmidt, D.2
  • 41
    • 0036193683 scopus 로고    scopus 로고
    • Selective blockade of N-type calcium channels by levetiracetam
    • Lukyanetz E.A., Shkryl V.M., and Kostyuk P.G. Selective blockade of N-type calcium channels by levetiracetam. Epilepsia 43 (2002) 9-18
    • (2002) Epilepsia , vol.43 , pp. 9-18
    • Lukyanetz, E.A.1    Shkryl, V.M.2    Kostyuk, P.G.3
  • 43
    • 0033800837 scopus 로고    scopus 로고
    • Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs
    • Margineanu D.G., and Klitgaard H. Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs. Pharmacological Research 42 (2000) 281-285
    • (2000) Pharmacological Research , vol.42 , pp. 281-285
    • Margineanu, D.G.1    Klitgaard, H.2
  • 44
    • 0037453386 scopus 로고    scopus 로고
    • Levetiracetam has no significant gamma-aminobutyric acid-related effect on paired-pulse interaction in the dentate gyrus of rats
    • Margineanu D.G., and Klitgaard H. Levetiracetam has no significant gamma-aminobutyric acid-related effect on paired-pulse interaction in the dentate gyrus of rats. European Journal of Pharmacology 466 (2003) 255-261
    • (2003) European Journal of Pharmacology , vol.466 , pp. 255-261
    • Margineanu, D.G.1    Klitgaard, H.2
  • 46
    • 0035933671 scopus 로고    scopus 로고
    • Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices
    • Niespodziany I., Klitgaard H., and Margineanu D.G. Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices. Neuroscience Letters 306 (2001) 5-8
    • (2001) Neuroscience Letters , vol.306 , pp. 5-8
    • Niespodziany, I.1    Klitgaard, H.2    Margineanu, D.G.3
  • 47
    • 0033621925 scopus 로고    scopus 로고
    • Pharmacokinetic profile of levetiracetam: toward ideal characteristics
    • Patsalos P.N. Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacology and Therapeutics 85 (2000) 77-85
    • (2000) Pharmacology and Therapeutics , vol.85 , pp. 77-85
    • Patsalos, P.N.1
  • 51
    • 0032918385 scopus 로고    scopus 로고
    • Clinical aspects and biological bases of drug-resistant epilepsies
    • Regesta G., and Tanganelli P. Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Research 34 (1999) 109-122
    • (1999) Epilepsy Research , vol.34 , pp. 109-122
    • Regesta, G.1    Tanganelli, P.2
  • 52
    • 0020514299 scopus 로고
    • Why Does Epilepsy Become Intractable - Prevention of Chronic Epilepsy
    • Reynolds E.H., Elwes R.D.C., and Shorvon S.D. Why Does Epilepsy Become Intractable - Prevention of Chronic Epilepsy. Lancet 2 (1983) 952-954
    • (1983) Lancet , vol.2 , pp. 952-954
    • Reynolds, E.H.1    Elwes, R.D.C.2    Shorvon, S.D.3
  • 56
    • 27844509190 scopus 로고    scopus 로고
    • Is levetiracetam distinct from conventional antiepileptic drugs in antiepileptogenic properties in spontaneous epileptic rats?
    • Sasa M., Yan H.D., Ishihara K., Nagayama T., and Serikawa T. Is levetiracetam distinct from conventional antiepileptic drugs in antiepileptogenic properties in spontaneous epileptic rats?. Epilepsia 46 (2005) 94-95
    • (2005) Epilepsia , vol.46 , pp. 94-95
    • Sasa, M.1    Yan, H.D.2    Ishihara, K.3    Nagayama, T.4    Serikawa, T.5
  • 58
    • 0037072554 scopus 로고    scopus 로고
    • Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions
    • Seegers U., Potschka H., and Löscher W. Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions. European Journal of Pharmacology 451 (2002) 149-155
    • (2002) European Journal of Pharmacology , vol.451 , pp. 149-155
    • Seegers, U.1    Potschka, H.2    Löscher, W.3
  • 60
    • 42949103950 scopus 로고    scopus 로고
    • Steinberg, M., Faissler, D., 2004. Levetiracetam therapy for longterm idiopathic epileptic dogs. In: Proceedings of the 22nd Annual American College of Veterinary Internal Medicine Forum.
    • Steinberg, M., Faissler, D., 2004. Levetiracetam therapy for longterm idiopathic epileptic dogs. In: Proceedings of the 22nd Annual American College of Veterinary Internal Medicine Forum.
  • 61
    • 0034892646 scopus 로고    scopus 로고
    • A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brain
    • Tong X., and Patsalos P.N. A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brain. British Journal of Pharmacology 133 (2001) 867-874
    • (2001) British Journal of Pharmacology , vol.133 , pp. 867-874
    • Tong, X.1    Patsalos, P.N.2
  • 62
    • 0032534075 scopus 로고    scopus 로고
    • Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants: 122 cases (1992-1996)
    • Trepanier L.A., Van Schoick A., Schwark W.S., and Carrillo J. Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants: 122 cases (1992-1996). Journal of the American Veterinary Medical Association 213 (1998) 1449-1453
    • (1998) Journal of the American Veterinary Medical Association , vol.213 , pp. 1449-1453
    • Trepanier, L.A.1    Van Schoick, A.2    Schwark, W.S.3    Carrillo, J.4
  • 63
    • 42949125276 scopus 로고    scopus 로고
    • Von Klopmann, T., Simon, D., Tipold, A., 2005. Zonisamide add-on therapy for canine refractory epilepsy: Benefit or "Honey -Moon Effect". In: Proceedings of 18th Annual European College of Veterinary Neurologist Symposium, Munich, Germany.
    • Von Klopmann, T., Simon, D., Tipold, A., 2005. Zonisamide add-on therapy for canine refractory epilepsy: Benefit or "Honey -Moon Effect". In: Proceedings of 18th Annual European College of Veterinary Neurologist Symposium, Munich, Germany.
  • 64
    • 0035093557 scopus 로고    scopus 로고
    • ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery
    • Wieser H.G., Blume W.T., Fish D., Goldensohn E., Hufnagel A., King D., Sperling M.R., Luders H., and Pedley T.A. ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia 42 (2001) 282-286
    • (2001) Epilepsia , vol.42 , pp. 282-286
    • Wieser, H.G.1    Blume, W.T.2    Fish, D.3    Goldensohn, E.4    Hufnagel, A.5    King, D.6    Sperling, M.R.7    Luders, H.8    Pedley, T.A.9
  • 66
    • 23944432461 scopus 로고    scopus 로고
    • Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER)
    • Yan H.D., Ji-qun C., Ishihara K., Nagayama T., Serikawa T., and Sasa M. Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER). Epilepsia 46 (2005) 1170-1177
    • (2005) Epilepsia , vol.46 , pp. 1170-1177
    • Yan, H.D.1    Ji-qun, C.2    Ishihara, K.3    Nagayama, T.4    Serikawa, T.5    Sasa, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.